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| 1 | The epigenetics of CHARGE syndrome显示文摘在生物学,当试图为复杂特点解释复杂继承模式时,我们继续欣赏 DNA 顺序独自突然掉落的事实。这为看起来有简单基因原因的人的混乱是特别地真的。epigenetics 的学习,和不同纸巾的 epigenetic 侧面的增加的存取开始使许多基本生物进程的基因复杂性清楚些,生理、病理学。Epigenetics 在不由于在 DNA 顺序的改变的基因表示指可继承的变化。epigenetic 规定的各种各样的机制存在,包括 DNA methylation 和 histone 修正。关键播放器的鉴定和 epigenetic 规定的机制开始提供了重要卓见进各种各样的人的基因混乱的内在的起源。一如此的混乱是费用症候群(OMIM #214800 ) ,它是一个领先的原因聋盲目世界范围。费用症候群盒子的一个多数被 haploinsufficiency 为 CHD7 基因引起,它编码改变涉及基因表示的 epigenetic 规定的蛋白质的 ATP 依赖的染色质。CHD7 蛋白质高度在整个进化,和对在多重模型系统的相当或相同的事物增加了我们一般来说理解蛋白质,和 epigenetic 机制的这个家庭的 CHD7 的函数的研究被保存了。这里,我们提供费用症候群的评论,并且在模型有机体在人和 CHD7 相当或相同的事物讨论 CHD7 的 epigenetic 功能。 | Nina K. Latcheva Rupa Ghosh Daniel R. Marenda | 2016 | Frontiers in Biology2016，11，2： | 1 |
| 2 | A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme显示文摘The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy exists.Ionizing radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing osteoclast.We demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic bone.At reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic activities.These properties make cerium oxide nanomaterials fascinating.We show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and strength.These investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in vivo.Further,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in vitro.These findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials. | Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup | 2023 | Bioactive Materials2023，，3： | 0 |
| 3 | Acetylcholinesterase Characteristics of Termite Queen Exposed to Anticholinesterase Compounds显示文摘A regional profile of AChE activity was noted in the Indian termite queen Odontotermes redemanni with the head recording the higher and body the lower range o activity.The enzyme characteristics suh as substrate and temperature optima were more or less similar while pH requirement for optimum AChE activity varied from 7.0 to 7.6In vitro inhibition of head and body AChE was studied using pure and commercial anticholinesterase compounds.Interestingly,the commercial formulations like Metacid-50 and Carbaryl are potent enough at 1×10^-8M to produce 50% in vitro inhibition of AChE of head and body regions within 15 min of preincubation.A 20 min or preincubation(t0.5)was necessary to record 50% in vitro inhibition of AChE with known and pure anticholinesterase compounds such as DFP(3.5×10^-10M) and physostigmine(3.6×10^-10M).It is surmised that (a)the response of the head and body AChE tp the commercial formulations of the insecticides may be used as a reliable and sensitive biolindicator of pesticidal contamination of the terrestrial environment and (b)termite control may be successfully done with the application of organophosphate or carbamate compounds. | SHELLEY BHATTACHARYA PROBODH GHOSH SHAMPA GHOSH NINA GHOSH B.BHATTACHARYA P.HALDER | 1992 | Biomedical and Environmental Sciences1992，5，2： | 0 |
| 4 | Thyrotoxicity of the Chlorides of Cadmium and Mercury in Rabbit显示文摘Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern.The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction.Cadmium and mercury treatment at LD50 levels resulted in severe thyrotoxicosis in the rabbit.Within 24h of intramuscular administration of cadmium chloride 15 mg·kg^-1 body weight(bw)and mercury chloride20mg·kg^-1 bw,thyroid peroxidase activity increased significantly over the control with a concomitant rise in the triiodothyronie(T3)titre.On the other hand,there was a remarkable fall in the thyroxine(T4)level,and the T3,T4 ratio was high as compared with the control.Evidence indicates that acute heavy metal lethality will induce immediate hyperthyroidism.It is suggested that T3-toxicosis may be produced by a preferential synthesis of T3 and/or preferential deiodination of T4 to T3.Measurement of T3 and T4 levels may thus e utilized as a reliable indicator of heavy metal lethality. | NINA GHOSH SHELLEY BHATTACARYA | 1992 | Biomedical and Environmental Sciences1992，5，3： | 0 |
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