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| 1 | Molecular approaches for spinal cord injury treatment显示文摘Injuries to the spinal cord result in permanent disabilities that limit daily life activities.The main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic injuries.Despite decades of research,there is still no efficient treatment for spinal cord injury.Many strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord injury.Among these,molecular compounds are currently being used for neurological recovery,with promising results.These molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost connections.In this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and purines.The mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans. | Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez | 2023 | Neural Regeneration Research2023，18，1： | 3 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 4 | Role of DL-lactic acid as an intermediate in rumen metabolism of dairy cows显示文摘 | COUNOTTE G H M LANKHORST A PRINS R A | 1983 | Journal of Animal Science1983，56，： | 1 |
| 5 | Controls on terrigenous sediment supply to the Arabian Sea during the Late Quaternary : the Makran continental slope 显示文摘 | Prins M A Postma G Weltije G | 2000 | Marine Geology2000，169，： | 1 |
| 6 | Ni EXAFS studies of the Ni-Mo S structure in carbon-supported and alumina-supported Ni-Mo catalysts显示文摘 | Louwers S P A Prins R | 1992 | J Catal1992，133，1： | 1 |
| 7 | The functional role of mussels in the Oosterschelde Estuary显示文摘 | Smaal A C Vonck W Prins T C | 1990 | J Shellfish Res1990，，9： | 1 |
| 8 | Increased expression of the breast cancer resistance protein(BCRP)in relapsed or refractory acute myeloid leukemia(AML)显示文摘 | Van den Heuvel-Eibrink M Wiemer E Prins A | 2002 | Leukemia2002，16，5： | 1 |
| 9 | Carbohydrate fermentation by the tu- reen ciliate isotrichaprostoma显示文摘 | Prins R A Hoven W | 1977 | Protistologica1977，13，3： | 1 |
| 10 | Application of DDRT-PCR to the analysis of differential gene expression in a plant-fungus interaction显示文摘 | Prins T van Kan J A | 1996 | Plant Molecular Biology1996，32，5： | 1 |
| 11 | A 300-kyr record of aridity and wind strength in southwestern African : inference from grain-size distributions of sediments on Walvis Ridge, Southeast Atlantic 显示文摘 | Stuut J B Prins M A Schneider P R | 2002 | Marine Geology2002，180，： | 1 |
| 12 | An EXAFS study on the Ni and W environment in carbon-supported,sulfided W and Ni-W cata lysts显示文摘 | Louwers S P A Prins R | 1993 | J Catal1993，139，2： | 1 |
| 13 | Mechanisms of hydrodesulfurization and hydrodenitrogenation显示文摘 | PRINS R EGOROVA M R(O)THLISBERGER A ZHAO Y SIVASANKAR N KUKULA P | | 0，，1： | 1 |
| 14 | Tracking rodent - dispersed large seeds with passive integrated transponder ( PIT ) tags 显示文摘 | Suselbeek L Jansen P A Prins H H T | 2013 | Methods in Ecology and Evolution2013，4，6： | 1 |
| 15 | Principles of a novel multistage circulating fluidized bed reactor for biomass gasification显示文摘 | Sascha R A K Wolter Prins Bram van der Drift | 2003 | Chemical Engineering Science2003，58，36： | 1 |
| 16 | Particle segregation in fluidized binary mixtures显示文摘 | Hoffmann A C Janssen M L P B J Prins | 1993 | Chem Eng Sci1993，48，9： | 1 |
| 17 | Hemodynamie instability in sepsis :bedside assessment by Doppler echoeardiosraphy显示文摘 | Vieillard-Baron A Prin S Chergui K | 2003 | Am J Resp Crit Care Med2003，168，： | 1 |
| 18 | Effects of climate,sea level,and tectonics unraveled for last deglaciation turbidite records of the Arabian Sea显示文摘 | Prins M A Postma G | 2000 | Geology2000，28，4： | 1 |
| 19 | Calphad显示文摘 | Prins S N Cornish L A Stumpf W E | 2003 | 27(1):792003，27，1： | 1 |
| 20 | Modelling of flash pyrolysis of a single particle显示文摘 | Janse A M C Westerhout R W J Prins W | 2000 | Chemical Engineering and Processing2000，39，3： | 1 |
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