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| 1 | Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer:efficacy,safety,and biomarker results from Chinese patients显示文摘Overexpression of human epidermal growth factor receptor-2(HER2) in metastatic breast cancer(MBC) is associated with poor prognosis.This single-arm open-label trial(EGF109491;NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive MBC.The primary endpoint was clinical benefit rate(CBR).Secondary endpoints included progression-free survival(PFS),time to response(TTR),duration of response(DoR),central nervous system(CNS) as first site of relapse,and safety.The results showed that there were 23 patients with partial responses and 7 patients with stable disease,resulting in a CBR of 57.7%.The median PFS was 6.34 months(95% confidence interval,4.93-9.82 months).The median TTR and DoR were 4.07 months(range,0.03-14.78 months) and 6.93 months(range,1.45-9.72 months),respectively.Thirteen(25.0%) patients had new lesions as disease progression.Among them,2(3.8%) patients had CNS disease reported as the first relapse.The most common toxicities were palmar-plantar erythrodysesthesia(59.6%),diarrhea(48.1%),rash(48.1%),hyperbilirubinemia(34.6%),and fatigue(30.8%).Exploratory analyses of oncogenic mutations of PIK3CA suggested that of 38 patients providing a tumor sample,baseline PIK3CA mutation status was not associated with CBR(P = 0.639) or PFS(P = 0.989).These data confirm that the lapatinib plus capecitabine combination is an effective and well-tolerated treatment option for Chinese women with heavily pretreated MBC,irrespective of PIK3CA status. | Bing-He Xu Ze-Fei Jiang Daniel Chua Zhi-Min Shao Rong-Cheng Luo Xiao-Jia Wang Dong-Geng Liu Winnie Yeo Shi-Ying Yu Beth Newstat Alka Preston Anne-Marie Martin Hai-Dong Chi Li wang | 2011 | Chinese Journal of Cancer2011，30，5： | 17 |
| 2 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 3 | Optical haze of transparent and conductive silver nanowire films显示文摘当代的 nanostructured 为在太阳能电池的使用的透明电极要求高发射度和高电导率,与高方面比率支配 nanostructures。光薄雾是在为被 nanostructures 的几何学也决定的太阳能电池的透明电极的一个同等地重要的还未学得的参数填写电极。在这个工作,在可见光谱的光薄雾价值上的银 nanowire 直径的效果用与小直径(60 nm ) 或大直径(150 nm ) 由电线组成的电影被调查。有限差别时间领域(FDTD ) 模拟和试验性的发射度数据证实更高根据优点的当前的数字的意见执行透明进行的电极(TCE ) 电影的那种更小的直径 nanowires 形式。当为每部电影在经常的发射度和电导率附近维持时,然而,电影与更大的直径银 nanowires 创作了,这试验性地被观察与更小的直径比电影有一个更高的薄雾因素。这与同样大、小的直径为单个 nanowires 证实薄雾因素的 FDTD 模拟。这是为被模仿了或试验性地测量了的 Ag NW 的薄雾性质的第一个记录,并且也,第一证实为 TCE 的优点的当前的数字是不够的在太阳能电池设备评估他们的表演。 | Colin Preston Yunlu Xu Xiaogang Han Jeremy N. Munday Liangbing Hu | 2013 | Nano Research2013，6，7： | 13 |
| 4 | 颈部动脉夹层分离及其与颈椎推拿疗法的联系:美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘目的:颈部动脉夹层分离(cervicalarterydissection,CD)是中青年人卒中的最常见病因。本指南旨在对CD诊治的现有证据水平以及其与颈椎推拿疗法(cervical manipulative therapy, CMT)的统计学联系进行回顾。某些类型的CMT是由医疗专业人员对颈椎施加猛烈或轻柔的推力。方法写作组成员由美国心脏协会卒中委员会的科学声明监督委员会以及美国心脏协会的手稿监督委员会任命。各成员负责与其专业领域相关的主题,回顾适当的文献并参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有证据进行总结并指出目前的知识空白。结果CD患者可表现为单侧头痛、后颈部痛或主要由动脉-动脉栓塞导致的脑或视网膜缺血(短暂性缺血或卒中)、CD脑神经麻痹、眼交感神经麻痹或搏动性耳鸣。CD的诊断依赖于完整的病史、体格检查和针对性的辅助检查。尽管轻微创伤的作用存在争议,但机械压力可造成椎动脉和颈内动脉内膜损伤,进而导致CD。CD患者的残疾程度存在差异,一些患者预后良好,但有些患者则会出现严重神经系统后遗症。目前尚无循证指南可用来指导CD的最佳处理策略。抗血小板和抗凝治疗均被用于局部血栓和继发性栓塞的预防。病例对照研究和其他文献提示CD[尤其是椎动脉夹层分离(vertebral artery dissection, VAD)]与CMT之间存在流行病学联系,但尚不清楚这是由于对先前存在的CD认识不足还是CMT导致的创伤。超声、CT血管造影以及磁共振血管造影都有助于CD的诊断。神经影像学随访首选无创性检查措施,但我们认为任何单一的检查方法都不能作为金标准。结论 CD是中青年患者发生缺血性卒中的重要病因。CD最好发于颈椎上段,可累及颈内动脉或椎动脉。尽管目前的生物力学证据不足以证实CMT 可导致CD,但临床报道提示机械压力在相当一部分CD中起着一定的作用,而且大多数基于人群的对照研究在年轻患者中显示CMT与VAD卒中之间存在联系。尽管对于曾经接受过CMT的患者,CMT相关性CD的发生率尚不完全清楚并且很可能较低,但当有临床症状时,医生应考虑到CD的可能性,并且在进行颈椎推拿前告知患者CD与CMT之间的统计学联系。 | José Biller Ralph L. Sacco Felipe C. Albuquerque Bart M. Demaerschalk Pierre Fayad Preston H. Long Lori D. Noorollah Peter D. Panagos Wouter I. Schievink Neil E. Schw artz Ashfaq Shuaib David E. Thaler David L. Tirschw ell 牛牧 陈进 宋艳 吴丹 王玉琴 柯开富 | 2015 | 国际脑血管病杂志2015，23，5： | 8 |
| 5 | 对遗传性易栓症检查与治疗的指导意见显示文摘国际上对易栓症尚无统一的定义。英国血液学会标准化委员会提出,易栓症是指“易导致血栓形成的止血机理异常”。这个定义被广泛地采用,但也有两点不足之处:①随着新的易栓状态不断发现,很多有这类异常的人并无症状;②虽然已认识到各种能增加血栓危险的异常,但至少50%有血栓病史的患者经详细的实验室检查后仍找不到原因。在北美地区医生将易栓症患者限定为有自发性静脉血栓或其严重性比预期的高,或反复性静脉血栓发作,或在年青时就有静脉血栓的人。这个概念可能在临床上更有用。 | Walker ID Greaves M Preston FE 王兆钺 | 2004 | 国外医学(输血及血液学分册)2004，27，6： | 8 |
| 6 | Transcriptional and epigenetic regulation of immune tolerance:roles of the NF-κB family members显示文摘Immune tolerance is a highly regulated state and involves diverse mechanisms.Central to the induction of tolerance is the targeted modulation of T-cell activities(both effector and regulatory),in which transcription factors play a significant role.The nuclear factor kappa-B(NF-κB)family is a family of transcription factors that not only are critically involved in diverse T-cell responses but also are regulated by many mechanisms to maintain tolerance and T-cell homeostasis.NF-κB,as a transcription factor,has been extensively studied in recent decades,and the molecular mechanisms that regulate NF-κB activities have been well documented.However,recent studies have revealed exciting new roles for NF-κB;in addition to its transcriptional activity,NF-κB can also activate diverse epigenetic mechanisms that mediate extensive chromatin remodeling of target genes to regulate T-cell activities.In this review article,we highlight recent discoveries and emerging opportunities in targeting NF-κB family members as well as their associated chromatin modifiers in the induction of immune tolerance and in the clinical treatment of immune diseases. | Lei Zhang Xiang Xiao Preston R.Arnold Xian C.Li | 2019 | Cellular & Molecular Immunology2019，16，4： | 5 |
| 7 | Scalable nanomanufacturing of surfactant-free carbon nanotube inks for spray coatings with high conductivity显示文摘Spray-coated carbon nanotube films offer a simple and printable solution for fabricating low cost, lightweight, and flexible thin-film electronics. However, current nanotube spray inks require either a disruptive surfactant or destructive surface functionalization to stabilize dispersions at the cost of the electrical properties of the deposited film. We demonstrate that high-purity few-walled carbon nanotubes may be stabilized in isopropanol after surface functionalization and that optimizing the ink stability dramatically enhances the conductivity of subsequent spray-coated thin films. We consequently report a surfactant-free carbon nanotube ink for spray-coated thin films with conductivities reaching 2,100 S/cm. Zeta-potential measurements, used to quantify the nanotube ink dispersion quality, directly demonstrate a positive correlation with the spray- coated film conductivity, which is the key metric for high-performance printed electronics. | Colin Preston Da Song Jaiqi Dai Zois Tsinas John Bavier John Cumings Vince Ballarotto Liangbing Hu | 2015 | Nano Research2015，8，7： | 4 |
| 8 | M13 Bacteriophage-Polymer Nanoassemblies as Drug Delivery Vehicles显示文摘Poly (caprolactone-b-2-vinylpyridine )(PCL-P2VP ) 与叶酸结合 M13 (FA-M13 ) 涂提供能够包含象 doxorubicin (纪录影片) 那样的恐水病的 antitumor 药的一个 nanosized 交货系统。装载纪录影片的 FA-M13-PCL-P2VP 集会有约 200 nm 的一条平均直径,他们的结构用传播电子显微镜学被描绘,扫描电子显微镜学,并且动态轻散布。粒子在生理的 pH 是稳定的,但是能在更低的 pH 被降级。从在酸的条件下面的 nanoassemblies 的纪录影片的版本比在生理的 pH 观察了的被显示显著地快。另外,装载纪录影片的 FA-M13-PCL-P2VP 粒子比 folate-receptor-negative 房间对 folate-receptor-positive 癌症房间显示出显然更大的细胞的举起和 cytotoxicity,显示受体便于经由调停受体的 endocytosis 的叶酸的举起。而且,装载纪录影片的粒子也与免费纪录影片相比有显著地更高的肿瘤举起和选择。这研究因此提供一个新方法制作 nanosized 药交货车辆。 | Nisaraporn Suthiwangcharoen Tao Li Kai Li Preston Thompson Shaojin You Qian Wang | 2011 | Nano Research2011，4，5： | 4 |
| 9 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 10 | Increased β-Cyanoalanine Nitrilase Activity Improves Cyanide Tolerance and Assimilation in Arabidopsis显示文摘植物自然地生产被快速的吸收的一个过程在他们的房间在底层维持的氰化物(CN ) 。然而,与象工业污染那样的活动联系的环境 CN 的高集中对植物有毒。因此对作为一条潜在的线路增加植物的 CN detoxification 能力到植物救治有兴趣。这里, Pseudomonas fluorescens -cyanoalanine nitrilase pinA 与相比的 Arabidopsis 幼苗 overexpressing 野类型并且为生长的一根 -cyanoalanine nitrilase 大美人线(Atnit4 ) 面对外长的 CN。在有 CN 的孵化以后, +PfpinA 幼苗增加了漂白与相比的根长度,增加的新鲜重量,和减少的叶野类型,显示增加了 CN 忍耐。没有 -cyanoalanine synthase 活动的增加,增加的忍耐被完成,在氰化物吸收小径的另外的酶,建议那项 nitrilase 活动是为氰化物 detoxification 的限制因素。用标记实验[13C ] KCN 证明改变的 CN 忍耐能被差别向改变的 -cyanoalanine nitrilase 活动引起的 Asn 从 CN 在流动解释。代谢物在 CN 处理以后介绍提供了新卓见进下游的新陈代谢,揭示由 photorespiratory 氮周期和芳香的氨基酸的累积的 Asn 的向前的新陈代谢。 | Brendan O'Leary GaU M. Preston Lee J. Sweetlove | 2014 | Molecular Plant2014，7，1： | 3 |
| 11 | The eco-physiological complexity of plant responses to insect herbivores显示文摘 | BALDWIN I T PRESTON C A | 1999 | Planta1999，208，： | 2 |
| 12 | The Selective Solvent Extraction of Cadmium By Mixtures of Carboxylic Acids and Trialkylphosphine Sulphides 显示文摘 | Preston J S | 1994 | Hydrometallurgy1994，，36： | 2 |
| 13 | 法国高速铁路网络的扩张显示文摘法国高速铁路东线二期工程的开通缩短了旅行时间,本文概述了相关建设。 | Robert Preston 曲辰雨(翻译) 刘宏友(校) | 2019 | 国外铁道车辆2019，56，4： | 2 |
| 14 | MR imaging of the knee: exanole of normal anatomy and pathology 显示文摘 | Kean DM Worthington BS Preston BJ | 1983 | Br J Radiol1983，56，： | 2 |
| 15 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 16 | Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance显示文摘 | Jung JS Bhat RV Preston GM | 1994 | Proc Natl Acad Sci USA1994，91，13： | 2 |
| 17 | Laser Induced Periodic Surface Damage and Radiation Remnants 显示文摘 | YOUNG J F SIPE J E PRESTON J S | 1982 | Appl Phys Lett1982，41，： | 1 |
| 18 | Body composition in cancer cachexia显示文摘 | Fearon KC Preston T | 1990 | Infusionstherapie1990，17，3： | 1 |
| 19 | The new stem cell biology : something foreveryone 显示文摘 | Preston SL Alison MR Forbes SJ | 2003 | J Clin Pathoh : Mol pathol2003，56，2： | 1 |
| 20 | Novoseven use in a non-cardiac pediatric ECMO patient with uncontrolled bleeding显示文摘 | Preston TJ Olshove VF Jr Ayad O | 2008 | J Extra Corpor Technol2008，40，2： | 1 |
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