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| 1 | 糖尿病血糖正常的探索:控制餐后血糖显示文摘在“首届诺和诺德糖尿病论坛”召开一周年之际 ,诺和诺德公司于 2 0 0 3年 2月 12~ 14日在杭州再次召开了大型全国糖尿病专家研讨会。与会人员涉及全国 30余个省、市及自治区的 4 5 0余位糖尿病专家、医生。 2 0余位国内外专家在此作了精彩的演讲。会议紧紧围绕当今糖尿病研究领域的热点问题 ,尤其是对胰岛 β细胞功能受损在 2型糖尿病发病中的作用机制 ,β细胞功能的评估及检测 ,保护 β细胞功能的措施 ,控制高血糖及外源性胰岛素的使用等方面进行了深入细致的研讨。以下全文刊出了国内外 16位著名专家在此次“论坛”会上的专题报告 ,及“诺和诺德”公司的新产品简介 ,全面报道了本次“论坛”会的内容。 | Stefano Del Prato | 2003 | 国外医学(内分泌学分册)2003，23，3： | 34 |
| 2 | Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial显示文摘Background:We aimed to assess efficacy and safety,with a special focus on cardiovascular safety,of the novel dual GIP and GLP-1 receptor agonist tirzepatide versus insulin glargine in adults with type 2 diabetes and high cardiovascular risk inadequately controlled on oral glucose-lowering medications.Methods:This open-label,parallel-group,phase 3 study was done in 187 sites in 14 countries on five continents.Eligible participants,aged 18 years or older,had type 2 diabetes treated with any combination of metformin,sulfonylurea,or sodiumglucose co-transporter-2 inhibitor,a baseline glycated haemoglobin(HbA1c)of 7-5-10-5%(58-91 mmol/mol),body-mass index of 25 kg/m2 or greater,and established cardiovascular disease or a high risk of cardiovascular events.Participants were randomly assigned(1:1:1:3)via an interactive web-response system to subcutaneous injection of either once-per-week tirzepatide(5 mg,10 mg,or 15 mg)or glargine(100 U/mL),titrated to reach fasting blood glucose of less than 100 mg/dL.The primary endpoint was non-inferiority(0-3%non-inferiority boundary)of tirzepatide 10 mg or 15 mg,or both,versus glargine in HbA1c change from baseline to 52 weeks.All participants were treated for at least 52 weeks,with treatment continued for a maximum of 104 weeks or until study completion to collect and adjudicate major adverse cardiovascular events(MACE).Safety measures were assessed over the full study period.This study was registered with ClinicalTrials.gov,NCT03730662. | Stefano Del Prato | 2021 | 四川生理科学杂志2021，43，8： | 16 |
| 3 | 2型糖尿病患者个体化血糖控制目标和药物治疗显示文摘'有效管理糖尿病全球合作组织'(下称'糖尿病全球合作组织')成立的宗旨是为临床提供实用指南以改善糖尿病患者的预后,制定并修改相关策略以改善T2DM患者血糖控制情况。糖尿病全球合作组织提倡对糖尿病患者实行个体化治疗方案,明确需要特殊考虑T2DM患者亚组人群。这篇文章基于此前发表的文献,扩大了实用指南的范围,包括有并发症的新诊断T2DM患者和妊娠期糖尿病(GDM)患者。良好血糖控制是T2DM管理的基石,在预防或延缓糖尿病并发症的发生、发展过程中发挥重要作用。个体化治疗目标和安全及时的血糖达标治疗方案至关重要。另外,还需制定更全面的护理计划以降低心血管风险和改善患者预后。 | 张晓梅 纪立农 Bailey CJ Aschner P Stefano Del Prato LaSalle J JI Li-nong Matthaei S | 2014 | 中国糖尿病杂志2014，22，10： | 16 |
| 4 | 胰岛素早期分泌时相的丧失与餐后高血糖显示文摘在“首届诺和诺德糖尿病论坛”召开一周年之际 ,诺和诺德公司于 2 0 0 3年 2月 12~ 14日在杭州再次召开了大型全国糖尿病专家研讨会。与会人员涉及全国 30余个省、市及自治区的 4 5 0余位糖尿病专家、医生。 2 0余位国内外专家在此作了精彩的演讲。会议紧紧围绕当今糖尿病研究领域的热点问题 ,尤其是对胰岛 β细胞功能受损在 2型糖尿病发病中的作用机制 ,β细胞功能的评估及检测 ,保护 β细胞功能的措施 ,控制高血糖及外源性胰岛素的使用等方面进行了深入细致的研讨。以下全文刊出了国内外 16位著名专家在此次“论坛”会上的专题报告 ,及“诺和诺德”公司的新产品简介 ,全面报道了本次“论坛”会的内容。 | Stefano Del Prato | 2003 | 国外医学(内分泌学分册)2003，23，3： | 11 |
| 5 | Hemozoin triggers tumor necrosis factor alpha-mediated release of lysozyme by human adherent monocytes:new evidences on leukocyte degranulation in P.falciparum malaria显示文摘Objective:Avidly phagocytosed hemozoin(malarial pigment) alters several functions of human monocytes and stimulates generation of several cytokines.Recently,we showed that phagocytosis of hemozoin by human monocytes increases expression and activity of matrix metalloproteinase-9,a proteolytic enzyme available in specific gelatinase granules,which contain several enzymes including lysozyme.Present work investigated active lysozyme release after phagocytosis of hemozoin and its dependence on production of tumor necrosis factor alpha. Methods:After phagocytosis of hemozoin,hemozoin-containing trophozoites or control meals(opsonized nonparasitized red blood cells and latex particles),monocyte supematants were monitored for 2 hours,in presence of blocking anti-human tumor necrosis factor alpha antibodies or recombinant human tumor necrosis factor alpha cytokine in selected experiments.Lysozyme release was evaluated by a specific spectrometric assay measuring lysozyme activity after coincubation of cell supematants with suspensions of Mycrococcus Lysodeikticus,while levels of soluble tumor necrosis factor alpha were analyzed by specific enzyme-linked immunodsorbent assay. Results:Levels of lysozyme activity and soluble tumor necrosis factor alpha protein were increased in hemozoin in-or trophozoites-laden monocytes supematants.Phagocytosis per se(control meals) also increased lysozyme release,but levels were significantly lower than those obtained after phagocytosis of hemozoin or trophozoites. Interestingly,all effects on lysozyme release observed after phagocytosis were abrogated by blocking anti-human tumor necrosis factor alpha antibodies,while they were mimicked by recombinant human tumor necrosis factor alpha cytokine.Conclusions:Present work shows that phagocytosis of hemozoin promotes monocyte degranulation and enhances active lysozyme release.The effect requires tumor necrosis factor alpha mediation. | Mauro Prato Giribaldi G Arese P | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 6 | Early diverting colostomy for perianal sepsis in children with acute leukemia显示文摘 | Alessio Pini Prato Elio Castagnola Concetta Micalizzi Carlo Dufour Stefano Avanzini Luca Pio Edoardo Guida Girolamo Mattioli Vincenzo Jasonni Nicola Disma Leila Mameli Giovanni Montobbio Piero Buffa | 2012 | Journal of Pediatric Surgery2012，，10： | 2 |
| 7 | From control to eradication of malaria:the end of being stuck in second gear?显示文摘More than 2 billion people are at risk of malaria,which primarily affects poor populations in tropical and subtropical areas,including Southern Asia.As malaria incidence has been reduced strongly in some parts of endemic regions by combinations of interventions,including artemisinin-based therapies and insecticide-treated bed nets,a new goal has been established recently by charity foundations which support research on malaria:the worldwide eradication of the pathology.Doing away with control approaches which have been applied for the last 50 years and more focus on elimination objectives will deeply change priorities in the area of malaria treatment,chemoprevention,vector control,vaccine research and health system assessment.In this review,actual knowledge on pathogenesis and pharmacology is discussed,and new drugs, vaccines and insecticides are described. | Khadjavi Amina Giribaldi Giuliana Prato Mauro | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 8 | Loss of early insulin secretion leads to postprandial hyperglycaemia显示文摘 | S. Del Prato | 2003 | Diabetologia2003，，1： | 2 |
| 9 | Higher production of tumor necrosis factor alpha in hemozoin-fed human adherent monocytes is dependent on lipidic component of malarial pigment:new evidences on cytokine regulation in Plasmodium falciparum malaria显示文摘Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial pigment.Methods:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent assay.In selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of phagocytosis.Results:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these results.Additionally,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by 4-hydroxynonenal.Conclusions:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator. | Prato Mauro Gallo Valentina Arese Paolo | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 2 |
| 10 | Global technological collaboration network: network analysis of international co-inventions显示文摘 | Giuditta Prato Daniel Nepelski | 2014 | The Journal of Technology Transfer2014，，3： | 2 |
| 11 | Physiological and radiographic assessment during the development of pulmonary radiation fibrosis 显示文摘 | Prato FS Kurdyak R Saibil EA | 1977 | Radiology1977，122，2： | 1 |
| 12 | Stochastic Viability and Invariance显示文摘 | Aubin J P Da Prato G | 1990 | Annali Scuola Normale Di Pisa1990，17，： | 1 |
| 13 | Angew Chem lnt Ed 显示文摘 | Guldi D M Rahman G M A Prato M | 2005 | 44(13): 20152005，44，13： | 1 |
| 14 | Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics 显示文摘 | Klumpp C Kostarelos M Prato M | 2000 | Biochem Biophys Aeta2000，1758，3： | 1 |
| 15 | Multiple ant tribute Bayesian analysis of adaptive ecosystemmanagement显示文摘 | PRATO T | 2000 | Ecological Model2000，133，： | 1 |
| 16 | Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with gonadotropin-releasing hormone agonist 显示文摘 | Prato LD Borini A Cattoli M | 2002 | Fertil Steril2002，77，5： | 1 |
| 17 | Antigenic mapping of human thyroglobulin-Topographic relationship between antigenic regions and functional domains显示文摘 | Erregragui K Prato S Miquelis R | 1997 | Eur J Biochem1997，244，3： | 1 |
| 18 | Aspira-ting probe measurements of theunsteady total temperature field downstream of an embedded stator in a multistage axialflow compressor显示文摘 | Suryavamshi N Lakshminarayana B Prato J | 1998 | ASME Journal of Turbomachineary1998，120，： | 1 |
| 19 | Risk factors associated with bus accident severity in the United States: A generalized ordered logit model 显示文摘 | Sigal Kaplan Carlo Giacomo Prato | 2012 | Journal of Safety Research2012，，43： | 1 |
| 20 | Factors affecting the healing response of the intrabony defects following guided tissue regeneration and access flap surgery 显示文摘 | Tonetti MS Pini Prato G Cortellini P | 1996 | J Clin Periodon- tol1996，23，： | 1 |
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