|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Circadian phase dependent acute toxicity and pharmacokinetics of etidocaine in serum and brain of mice显示文摘 | Bruguerolle B Prat M | 1990 | J Pharm Pharmacol1990，42，： | 1 |
| 3 | Advances and applications of in- duced pluripotent stem cells 显示文摘 | Pietronave S Prat M | 2012 | Can J Physiol Pharmacol2012，90，： | 1 |
| 4 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 5 | Prognostic significance of progesterone receptor-positive tumor cells within immunohis- tochemically defined luminal a breast cancer 显示文摘 | Prat A Cheang MC Martin M | 2013 | J Clin On- col2013，31，2： | 1 |
| 6 | Development of real-time PCR systems based on SYBR(R) Green I, Amplifluor (TM) and TaqMan (R) technologies for specific quantitative detection of the transgenie maize event GA21 显示文摘 | Hernandez M Esteve T Prat S | 2004 | J Cereal Sci2004，39，： | 1 |
| 7 | Analysis of experiments of moisture migration caused by temperature differences in unsaturated porous medium by means of two-dimensional numerical simulation显示文摘 | Prat M | 1986 | International Journal of Heat and Mass Transfer1986，29，7： | 1 |
| 8 | Analysis of the influence of pH and pressure on the elimination of boron in reverse osmosis 显示文摘 | D Prats M F Chillon - Arias M Rodriguez - Pastor | 2000 | Desalination2000，128，3： | 1 |
| 9 | Serous borderline tumors of the ovary:A long-term follow-up study of 147 cases,including 18 with micropapillary pattern and 20 with micioinvasion显示文摘 | Prat J Nictolis M | 2002 | Am J Surg Pathol2002，26，： | 1 |
| 10 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 11 | Determination of quinolones in water samples by solid - phase extraction and liquid chromatography with fluorimetric detection 显示文摘 | Prat M D Benito J Compafi6 R | 2004 | J Chromatogr A2004，1041，1： | 1 |
| 12 | Pore-network simulalions of two-phase flow in a thin porous layer of mixed wettability : Application to water transport in gas diffusion layers of proton exchange membrane fuel cells显示文摘 | Kuttanikkad SP Prat M Pauchet J | 2011 | Journal of Power Sources2011，196，： | 1 |
| 13 | Development of real-time PCR systems based on SYBR~ Green I, Am- plifluorTM and TaqMan~ technologies for specific quantitative detection of the transgenic maize event GA21显示文摘 | Hern6ndez M Esteve T Prat S | 2004 | Journal of Cereal Science2004，39，1： | 1 |
| 14 | Extracorporeal high-intensity focused ultrasound for VX2 liver tumors in therabbit显示文摘 | PRAT F CENTARTI M SIBILLE A etal | 1995 | Hepatology1995，21，2： | 1 |
| 15 | Effect of vertical fractures on reservoir behavior- incompressible fluids case显示文摘 | Prats M | 1961 | SPEJ1961，，2： | 1 |
| 16 | Effect of vertical fractures on reservoir behavior incom- pressible fluid case显示文摘 | Prats M | | SPE5930，593，： | 1 |
| 17 | Deconstructing the molecular portraits of breast cancer显示文摘 | PRAT A PEROU C M | 2011 | Mol Oncol2011，5，1： | 1 |
| 18 | Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine显示文摘 | Prats C Donsmark M Qvortrup K | 2006 | J Lipid Res2006，47，11： | 1 |
| 19 | Deconstructing the molecular portraits of breast cancer显示文摘 | PRAT A PEROU C M | 2011 | Molecular Oncology2011，5，1： | 1 |
| 20 | Ultrasound-assisted extraction for rapid determination of Zn,Cu,Fe,Mg andMn in liver of diabetic rats under different antioxidant treatments显示文摘 | Prat M L Lopez-Gonzalvez A Ruiz M A | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，49，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员