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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | P-Selectin Expression and Kupffer Cell Activation in Rat Acute Pancreatitis显示文摘 | Emma Folch Neus Prats Georgina Hotter Santiago López Emilio Gelpi Joan Roselló-Catafau Daniel Closa | 2000 | Digestive Diseases and Sciences2000，，8： | 2 |
| 3 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 4 | Structural features of the cell-wall polysaccharides of Asparagus officinalis seeds显示文摘 | Goldberg R Gillou L Prat R | 1991 | Carbohyd Res1991，210，： | 1 |
| 5 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 6 | Ultrasound-assisted extraction for rapid determination of Zn,Cu,Fe,Mg andMn in liver of diabetic rats under different antioxidant treatments显示文摘 | Prat M L Lopez-Gonzalvez A Ruiz M A | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，49，4： | 1 |
| 7 | Abordaje integral d e un caso complejo de diabetes mellitus en domicilio entre la gestora de casos y la enfermera comunitaria显示文摘 | Marta Prats Guardiola Rosa María López Pisa | 2010 | Enfermería Clínica2010，20，2： | 1 |
| 8 | Ontogeny of aquaporins in human fetal membranes显示文摘 | Prat C Blanchon L Borel V | 2012 | Biol Reprod2012，86，2： | 1 |
| 9 | Fluorescence of metal complexes of 8-hydroxyquinoline derivatives in aqueous micellar media显示文摘 | Prat M D Compano R Beltran J L | | 0，，04： | 1 |
| 10 | 查看详情显示文摘 | Lopez J M Prat L | | 0，，： | 1 |
| 11 | Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications 显示文摘 | Wong LF Goodhead L Prat C | 2006 | Hum Gene Ther2006，17，1： | 1 |
| 12 | Effect of different extraction methods on bound EPS from MBR sludges:Part I:Influence of extraction methods over three-dimensional EEM fluorescence spectroscopy fingerprint显示文摘 | DOMINGUEZ L RODRIGUEZ M PRATS D | 2010 | Desalination2010，261，2： | 1 |
| 13 | NO Way to Live:the Various Roles of Nitric Oxide in Plant-pathogen Interactions显示文摘 | MUR L A J CARVER T L W PRATS E | 2006 | J Exp Bot2006，57，3： | 1 |
| 14 | GenoType MTBDRplus Assay for Molecular Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Strains and Clinical Samples 显示文摘 | A Lacoma N Garcia-Sierra C Prat J Ruiz-Manzano L Haba S Ros6s J Maldonado J Dominguez | 2008 | J Clin Microbiol2008，46，11： | 1 |
| 15 | Early EUS of the bile duct before endoscopic sphincterotomy for acute biliary pancreatitis显示文摘 | Frédéric Prat Jo?l Edery Bruno Meduri Renaud Chiche Charles Ayoun Michel Bodart Didier Grange Fran?oise Loison Pierre Nedelec Mohamed Sa?d Sbai-Idrissi Alain Valverde Bertrand Vergeau | 2001 | Gastrointestinal Endoscopy2001，，6： | 1 |
| 16 | Cis regulatory elements directing tuber-specific and sucrose-inducible expression of a chimeric class I patatin promoter/GUS- gene fusion显示文摘 | Liu X J Prat S Willmitzer L | 1990 | Mol Gen Genet1990，223，3： | 1 |
| 17 | Inducetion of a putative Ca2+ - ATPase mRNA in Nacl - adapted cells显示文摘 | Narasimhan M L Botella M A Chen Z | 1992 | Plant Physiol1992，100，： | 1 |
| 18 | One more role for the gut:microbiota and blood brain barrier显示文摘 | Michel L Prat A | 2016 | Ann Transl Med2016，4，1： | 1 |
| 19 | Aspirin prevents wound-induced gene expression in tomato leaves by blocking jasmonic acid biosynthesis显示文摘 | Pe(n)a-Cortés H Albrecht T Prat S Weiler EW Willmitzer L | | 0，，01： | 1 |
| 20 | Operating cost based cruise speed reduction for ground delay programs :effect of scope length显示文摘 | DELGADO L PRATS X | 2014 | Transportation Research Part C : Emerging Technologies2014，48，： | 1 |
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