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| 1 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 2 | Spontaneous transformation of human adult non-tumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma显示文摘 | Shims A Chettiar S Shepal V Rajendran G Prasad R Shastry P | 2007 | 中国神经肿瘤杂志2007，5，1： | 16 |
| 3 | An overview on antidiabetic medicinal plants having insulin mimetic property显示文摘Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8%of the world's population and is anticipated to cross 5.4%by the year 2025.Since long back herbal medicines have been the highly esteemed source of medicine therefore,they have become a growing part of modern,high-tech medicine.In view of the above aspects the present review provides profiles of plants(65 species) with hypoglycaemic properties,available through literature source from various database with proper categorization according to the parts used,mode of reduction in blood glucose(insulinomimetic or insulin secretagugues activity) and active phyloconsliluents having insulin mimetics activity.From the review it was suggested that,plant showing hypoglycemic potential mainly belongs to the family Leguminoseae,Lamiaceae,Liliaceae,Cucurbitaceae, Asteraceae,Moraceae,Rosaceae and Araliaceae.The most active plants are Allium sativum. Gymnema sylvestre,Citrullus colocynthis,Trigonella foenum greacum,Momordica charantia and Ficuts bengalensis.The review describes some new bioactive drugs and isolated compounds from plants such as roseoside,epigallocatechin gallate,beta-pyrazol-1-ylalanine,cinchonain Ib,leucocyandin 3-O-beta-d-galactosyl cellobioside,leucopelargonidin-3- O-alpha-L rhamuoside,glycyrrhetinic acid,dehydrotrametenolic acid,strictinin,isostrictinin,pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic agents.Thus,from the review majorly,the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols,flavonoida, terpenoids,coumarins and other constituents which show reduction in blood glucose levels.The review also discusses the management aspect of diabetes mellitus using these plants and their active principles. | Patel DK Prasad SK Kumar R Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 4 | Pedalium murex Linn(Pedaliaceae) fruits:a comparative antioxidant activity of its different fractions显示文摘Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic content.Methods:In the present study,the antioxidant activities of P.murex were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also investigated.Results:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing power.Correlation coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant activity.Conclusions:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health. | DK Patel R Kumar SK Prasad S Hemalatha | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 12 |
| 5 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 6 | Overview of multi-carrier CDMA 显示文摘 | Hara S Prasad R | 1997 | IEEE Communication Magazine1997，35，12： | 2 |
| 7 | Cataract: A major secondary complication of diabetes, its epidemiology and an overview on major medicinal plants screened for anticataract activity显示文摘 | DK Patel SK Prasad R Kumar S Hemalatha | 2011 | Asian Pacific Journal of Tropical Disease2011，，4： | 2 |
| 8 | Optimization of mobile IPv6 based handovers to support VoIP services in wireless heteroge neous networks显示文摘 | Fathi H Chakraborty S S Prasad R | 2007 | IEEE Transactions on Vehicular Technology2007，56，1： | 1 |
| 9 | Pendred syndrome,DFNB4,and PDS/SLC26A4 identification of eight novel mutation and possible genotype-phenotype correlations显示文摘 | CAMPBELL C CUCCI R A PRASAD S | 2001 | Hum Mutat2001，17，： | 1 |
| 10 | Zinc biosorption on Tectona grandis L leaves biomass:Equilibrium and kinetic studies显示文摘 | Kumar Y P King P Prasad V S R K | 2006 | Chemical Engineering Journal2006，124，1： | 1 |
| 11 | Hemorrhagic pleural effu- sion secondary to sarcoidosis:A brief review显示文摘 | Kumar S Verma SK Singh R Prasad R | 2009 | Ann Thorac Med2009，4，1： | 1 |
| 12 | Deformation and Fracture Behavior of Cast and Extruded 7075Al-SiCP Composites at Room and Elevated Temperature显示文摘 | Kulkarni M D Pobi P S Prasad R C | 1996 | Mater Trans JIM1996，37，： | 1 |
| 13 | Overview of multicarrier CDMA 显示文摘 | Hara S Prasad R | 1997 | IEEE Communications Magazine1997，35，12： | 1 |
| 14 | What to do when war- farin therapy goes too far显示文摘 | Prasad S Wootten M R Kulinski N | 2009 | J Fam Pract2009，58，7： | 1 |
| 15 | Experimen- tal study of an air-cooled thermal rnanagement system for high capacity lithium-titanate batteries 显示文摘 | Giuliano M R Ajay Prasad K Advani S G | 2012 | Journal of Power Sources2012，216，： | 1 |
| 16 | Micro- structural Modeling of Metadynamic Recrystallization in Hot Working of In718 Superalloy 显示文摘 | Medeiros S C Prasad Y V R K Frazier W G | 2000 | Materials Science and Engineering2000，293，： | 1 |
| 17 | An improved spatial smoothing technique for bearing estimation in multipath environment显示文摘 | Williams R Prasad S Mahalanabis A and Sibul L | 1988 | IEEE Trans on ASSP1988，36，4： | 1 |
| 18 | Overview'of multicarrier CDMA显示文摘 | HARAS S PRASAD R | 1997 | IEEE Commun Mag1997，35，12： | 1 |
| 19 | Enthalpy increments of strontium and barium zirconates显示文摘 | BANERJEE A DASH S PRASAD R SOOD D D | 1997 | Therm Acta1997，298，： | 1 |
| 20 | Hot working of commercial Ti-6A1-4V with an equiaxed a-β microstructure: materials modeling considerations 显示文摘 | Seshacharyulu T Medeiros S C Prasad Y V R K | 2000 | Materials Science and Engineering2000，284，： | 1 |
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