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| 1 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 2 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 3 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
| 4 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 5 | Phytotoxicity of cadmium ions on germination seedlings of mung bean (Phaseolus vulgaris): involvement of lipid peroxides in chlorophyll degradation显示文摘 | Somashekaraiah B V Padmaja K Prasad A R K | 1992 | Physiol Plant1992，85，： | 2 |
| 6 | Soil erosion under different rainfall intensities, surface roughness, and soil water regimes显示文摘 | M.J.M R?mkens K Helming S.N Prasad | 2002 | Catena2002，，2： | 2 |
| 7 | Experimental and finite element modeling studies on single-layer and multi-layer 1-3 piezocomposite transducers显示文摘 | RAMESH R PRASAD C D VINOD KUMAR T K | 2006 | Ultrasonics2006，44，2006： | 1 |
| 8 | Zinc biosorption on Tectona grandis L leaves biomass:Equilibrium and kinetic studies显示文摘 | Kumar Y P King P Prasad V S R K | 2006 | Chemical Engineering Journal2006，124，1： | 1 |
| 9 | , Electrochemically Synthesized MnO2-based Mixed Oxides for High Performance Redox Supercapacitors 显示文摘 | Prasad K R Miura N | 2004 | Communications2004，6，10： | 1 |
| 10 | Effect of lead and mercury on chlorophyll synthesis in mung bean seedlings显示文摘 | Prasad D D K A R K Prasad | 1987 | Phytochemistry1987，26，： | 1 |
| 11 | Electrochemically Synthesized MnO2-based Mixed Oxides for High Performance Redox Supercapacitors显示文摘 | PRASAD K R MIURA N | 2004 | Electrochemistry Communications2004，6，10： | 1 |
| 12 | Effect of lead and mercury on chlorophylls synthesis in mung bean seedlings显示文摘 | Prasad D D K Prasad A R K | 1987 | Phytochemistry1987，26，： | 1 |
| 13 | Synthesis of a re- usable oxotungsten-containing SBA-15 mesoporous catalyst for the organic solvent-free conversion of cyclohexene to a- dipic acid显示文摘 | Cheng C Y Lin K J Prasad M R | 2007 | Catal Commun2007，8，7： | 1 |
| 14 | Experimen- tal study of an air-cooled thermal rnanagement system for high capacity lithium-titanate batteries 显示文摘 | Giuliano M R Ajay Prasad K Advani S G | 2012 | Journal of Power Sources2012，216，： | 1 |
| 15 | Micro- structural Modeling of Metadynamic Recrystallization in Hot Working of In718 Superalloy 显示文摘 | Medeiros S C Prasad Y V R K Frazier W G | 2000 | Materials Science and Engineering2000，293，： | 1 |
| 16 | Characteriza- tion of phosphorus fractions in the sediments of a tropical in- tertidal mangrove ecosystem显示文摘 | BALA K PRASAD M R AM AN ATH AN A L | 2010 | Wetland Ecology and Man- agement2010，18，2： | 1 |
| 17 | Electrical and optical properties of TiO2 anatase thin films显示文摘 | Tang H Prasad K Sanjines R | 1994 | J Appl Phys1994，75，： | 1 |
| 18 | Pedunculated cribriform adenocarcinoma of the base of the tongue显示文摘 | Prasad K C Kaniyur V Pai R R | 2004 | Ear Nose Throat J2004，83，1： | 1 |
| 19 | Hot working of commercial Ti-6A1-4V with an equiaxed a-β microstructure: materials modeling considerations 显示文摘 | Seshacharyulu T Medeiros S C Prasad Y V R K | 2000 | Materials Science and Engineering2000，284，： | 1 |
| 20 | Processing maps for hot working of titanium alloys显示文摘 | PRASAD Y V R K SESHACHARYULU T | 1998 | Materials Science and Engineer ing1998，243，： | 1 |
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