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| 1 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 2 | 氧化铝对铁矿石烧结质量和生产率的影响(英文)显示文摘烧结矿是现代高炉生产的主要含铁原料。合理控制入炉烧结矿的理化性能与冶金性能对高炉生产和稳定操作是很必要的。铁矿粉是烧结矿的主要原料,其化学成分和烧结料层内的热量条件在烧结过程中起着重要的作用。化学成分等参数也决定着烧结矿矿相结构和质量。由于含氧化铝原料的低反应性及其液相的高粘性,因此在人们的预料中高铝矿石对烧结矿结构组成的影响并不好。烧结混合料中的氧化铝在同化过程中需要消耗大量热量,延迟烧结过程。在确保高炉渣的流动性方面,氧化铝也需要消耗较大热量。不论是烧结还是高炉的生产实绩均表明,氧化铝是有害的。一般而言,高含铁量与低脉石的印度矿与其他矿石的不同特点就是氧化铝含量高。由于高品味铁矿石的消耗殆尽,使用可利用的烧结原料成为生产必需。因此,必须要掌握氧化铝的作用及其对烧结矿质量和生产过程的影响。实验室完成了不同氧化铝含量水平(2.00%~5.46%)的实验,可从中了解氧化铝在烧结矿矿物学、生产率、物理性能和冶金性能方面的影响。随着烧结矿中氧化铝含量的增加,残存赤铁矿、复合铁酸钙(SFCA)和孔隙率增加,而磁铁矿和硅酸盐比例下降。烧结生产率和烧结矿转鼓强度(TI)随着氧化铝含量上升而下降,反映烧结矿冶金性能的诸如低温还原粉化率(RDI)和还原率(RI)提高。 | T Umadevi S Prakash U K Bandopadhyay P C Mahapatra M Prabhu Madhu Ranjan | 2010 | 世界钢铁2010，，1： | 4 |
| 3 | Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia in- duced oxidative stress in rats 显示文摘 | Mansoorali KP Prakash T Kotresha D | 2012 | Phytomedicine2012，19，12： | 1 |
| 4 | New mechanism contributing to drug-induced arrhythmia rescue of a misprocessed LQT3 mutant显示文摘 | Liu K Yang T Prakash C | 2005 | Circulation2005，112，： | 1 |
| 5 | Microstructure and mechanical properties of RSP/M Al-FeV-Si and Al-Fe-Ce alloys显示文摘 | Prakash U Raghu T Gokhale A A | 1999 | J Mater Sci1999，34，： | 1 |
| 6 | Characterization and behaviour of 15-lipooxygenase during peanutcotyledonary senescence显示文摘 | PRAKASH T SWAMY P REDDANNA P | 1990 | Biochem Biophys Res Commun1990，172，2： | 1 |
| 7 | Thermal buckling of simply supported functionally graded skew plates 显示文摘 | Ganapathi M Prakash T | 2006 | Composite Structures2006，74，2： | 1 |
| 8 | Tensile Fracture of Tin-lead Solder Joints in Copper显示文摘 | Prakash K H Sritharan T | 2004 | Materials Science and Engineering2004，379，12： | 1 |
| 9 | The management of malignant pleural mesothelioma:single centre experience in 10 years显示文摘 | Aziz T Jilaihawi A Prakash D | 2002 | Eur J Cardiothorac Surg2002，22，2： | 1 |
| 10 | Electrical and magnetic properties of Mn-Ni-Zn ferrites processed by citrate precursor method显示文摘 | SINGH A K VERMA A THAKUR O P CHANDRA PRAKASH GOEL T C MENDIRATTA R G | 2003 | Materials Letters2003，57，56： | 1 |
| 11 | Hot corrosion of some superailoys and role of high-velocity oxy-fuel spray eoatings-a review显示文摘 | SIDHU T S AGRAWAL R D PRAKASH S | 2005 | Surf Coat Technol2005，198，： | 1 |
| 12 | Formation of aluminum titanate-mullite composite from bauxite red mud 显示文摘 | Mahata T Prakash D Sharma B P | 2007 | Metallurgical and Materials Transactions B2007，31，3： | 1 |
| 13 | Asymmetric flexural vibration and thermoelastic stability of FGM circular plates using finite element method显示文摘 | Prakash T Ganapathi M | 2006 | Composites:Part B2006，37，： | 1 |
| 14 | Dielectric relaxation studies of nanocrystalline CuAlO2 using modulus formalism显示文摘 | Prakash T Prasad K P Kavitha R | 2007 | Journal of Applied Physics2007，，10： | 1 |
| 15 | Genome of anendosymbiont coupling N2 fixation to cellulolysis within protist cells intermite gut 显示文摘 | Hongoh Y Sharma VK Prakash T Noda S Toh H Taylor TD Kudo T Sakaki Y Toyoda A Hattori M Ohkuma M | 2008 | Science2008，322，5904： | 1 |
| 16 | Role of ryanodine receptor channels in Ca^2 + oscillations of porcine tracheal smooth muscle 显示文摘 | Kannan M S Prakash Y S Brenner T | 1997 | Am J Physiol1997，272，41： | 1 |
| 17 | Nonlinear free flexural vibrations of functionally graded rectangular and skew plates under thermal environments 显示文摘 | Sundararajan N Prakash T Ganapathi M | 2005 | Finite Elements in Analysis and Design2005，42，2： | 1 |
| 18 | Emission spectra of LnPO4: RE^3+ (Ln = La, Gd; RE = Eu, Tb and Ce) powder phosphors 显示文摘 | Rambabr U Munirathnam N R Prakash T L | 2002 | Mater Chem Phys2002，78，： | 1 |
| 19 | Tooth enamel defects in mice with a deletion at the Arhgap 6/Amd X locus显示文摘 | Prakash S K Gibson C W Wright J T | 2005 | Calcif Tis- sue Int2005，77，1： | 1 |
| 20 | Patient-controlled analgesia with fentanyl for burndressing changes显示文摘 | Prakash S Fatima T Pawar M | 2004 | Anesth Analg2004，99，2： | 1 |
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