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| 1 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 2 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 3 | Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic IBZM SPECT study 显示文摘 | Pogarell 0 Koch W Popper! G | 2006 | 1 Psychiatr Res2006，40，4： | 1 |
| 4 | Necrotizing sarcoid granulomatosis---is it different from nodular sarcoidosis 显示文摘 | Popper HH Klemen H Collby TV | 2003 | Pneumologie2003，57，： | 1 |
| 5 | Chronic liver injury induced by immunology reactions 显示文摘 | Paronetto F Popper H | 1996 | Am J Pathol1996，40，5： | 1 |
| 6 | Ankle-brachial blood pressure in elderly men and the risk of stroke:the Honolulu Heart Program显示文摘 | Abbott RD Rodriguez BL Petrovitch H Yano K Schatz IJ Popper JS | 2001 | J Clin Epidemiol2001，54，10： | 1 |
| 7 | Gene-expression patterns reveal underlying biological processes in Kawasaki disease显示文摘 | Popper SJ Shimizu C Shike H | 2007 | Genome Biol2007，8，12： | 1 |
| 8 | Anti-jamming broadcast communication using uncoordinated spread spectrum techniques显示文摘 | Popper C Strasser M | 2010 | IEEE Journal on Selected Areas in Communications2010，28，5： | 1 |
| 9 | A multifacel model of organizational learning 显示文摘 | LIPSHITZ R POPPER M FRIEDMAN V J | 2002 | Journal Of Applied Behavioral Science2002，，38： | 1 |
| 10 | Outline of the SECOQC QuantumKey Distribution Network in Vienna 显示文摘 | Popper A Peev M | 2008 | InternationalJournal of Quantum Information2008，6，2： | 1 |
| 11 | A survey on vision-based human action recognition显示文摘 | POPPER | 2010 | Image and Vision Computing2010，28，6： | 1 |
| 12 | Results of the premature birth national need-gap study显示文摘 | Berns S D Boyle M D Popper B | 2007 | J Perinatol2007，27，2： | 1 |
| 13 | Organizational LearningMechanisms: A Structural and CulturalApproach toOrganizational Learning显示文摘 | Popper M Lipshit Z R | 1998 | The Journal of AppliedBehavioral Science1998，34，2： | 1 |
| 14 | Noise -induced stress response and hearing loss in gold- fish(Carassius auratus) 显示文摘 | SMITH M E KANE A S POPPER A N | 2004 | Exp Biol2004，207，3： | 1 |
| 15 | Aging and the liver显示文摘 | Popper H | | 0，，： | 1 |
| 16 | Experimental cholestasis due to alpha-naphthylisothiocyanate (ANIT) 显示文摘 | Goldfarb S Singer E J Popper H | 1962 | Am J Pathol1962，40，： | 1 |
| 17 | Characteri of muscarinic cholinergic receptors in human ovaries,ovarian tumours ad tumour cell lines显示文摘 | Batra S Popper LD | 1993 | Eur Cancer1993，2，： | 1 |
| 18 | Diabetes and corne- al cell densities in humans by in vivn confocal mlcroscopy显示文摘 | Quadrado MJ Popper M Morgado AM | 2006 | Cornea2006，25，： | 1 |
| 19 | Bioacousties of fishes of the family Sciaenidae ( Croakers and Drums ) 显示文摘 | RAMCHARITAR J GANNON D P POPPER A N | 2006 | Transactions of the American Fisheries Society2006，135，5： | 1 |
| 20 | High intensity anthropogenic sound damages fish ears显示文摘 | MCCAULEY R D FEWTRWLL J POPPER A N | 2003 | AcoustSoc Am2003，113，1： | 1 |
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