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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 3 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 4 | Late miocene to pliocene paleogeography of the Paratethys and its relation to the Mediterranean显示文摘 | PoPov S V IRINA G S LUBOV B I | 2006 | Pataeogeography Palaeoclimatology Palaeoecology2006，238，： | 1 |
| 5 | Schwinger mechanism of electron positron pair production by the field of optical and X-ray lasers in vacuum显示文摘 | Popov V S | 2001 | JETP Lett2001，74，3： | 1 |
| 6 | Effect of stwmal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy显示文摘 | Askari AT Unzek S Popovic ZB | 2003 | Lancet2003，362，： | 1 |
| 7 | Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy显示文摘 | Askari AT Unzek S Popovic ZB | 2003 | Lancet2003，362，9385： | 1 |
| 8 | Cycle life and utilization studies on cobalt microencapsulated AB5 type metal hydride 显示文摘 | DURAIRAJAN A HARAN B S POPOV B N WHITE R E | 1999 | J Power Sources1999，83，： | 1 |
| 9 | Optimal Controller Designs for Rotating Machines-Penalising the Rate of Change of Control Forcing显示文摘 | Houlston P R Garvey S D Popov A A | 2006 | 7th IFToMM-Conference on Rotor Dynamics Vienna Austria 25 - 28 September 20062006，45，1： | 1 |
| 10 | Antiinflammatory activity of the pectic polysaccharide from Comarum palustre显示文摘 | POPOV S V POPOVA G Y OVODOVA R G | 2005 | Fitoterapia2005，76，34： | 1 |
| 11 | Features of the magnetoel-Ectric prop-erties of BiFeO3 in high magnetic fields显示文摘 | Popov Y F Kadomtseva A M Krotov S S | 2001 | Low Temp Phys2001，27，6： | 1 |
| 12 | A risk management procedure for supply restoration in distribution networks显示文摘 | Popovic D S Popovic Z N | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 13 | Chemistry of urea nitro derivatives HI Recation of N, N'-dinitrourea with bases显示文摘 | II'yasov S G Lobanova A A Popov N I | 2002 | Russian Journal of Organic Chemistry2002，38，12： | 1 |
| 14 | Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress 显示文摘 | Popovic V Pekic S Pavlovic D | 2004 | J Endocrinol Invest2004，27，11： | 1 |
| 15 | CD25 and indoleamine 2,3-dioxygenase are up?regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition显示文摘 | VON BERGWELT -BAILDON M S POPOV A SARIC T | 2006 | Blood2006，108，1： | 1 |
| 16 | Upregulation of MMP-13 via Runx2 in the stromal cell of giant cell tumorof bone显示文摘 | Mak IW Cowan RW Popovic S | 2009 | Bone2009，45，5： | 1 |
| 17 | Antibiotic therapy for exacerbations of chronic obstructive pulmonary disease ( C OPD ) 显示文摘 | Butorac - Petanjek B Parnham M J Popovic - Gale S | 2010 | C hemother2010，22，5： | 1 |
| 18 | Genome comparisons with chromosomal and molecular markers for three closely related Flax species and their hybrids显示文摘 | MURAVENKO V LEMESH V A SAMATADZE T E AMOSOVA A V GRUSHETSKAYA Z E POPOV K V YU O S KHOTYULEVA L V ZELENIN A V | 2003 | Russian Journal of Genetics2003，39，4： | 1 |
| 19 | Longitudinal cracking distress on continuously reinforced concrete pavements in Illinois 显示文摘 | Roesler J R Popovics J S Ranehero J L | 2005 | Journal of Performance of Constructed Facilities2005，19，4： | 1 |
| 20 | Tracking system with five degrees of freedom using a 2d-array of hall sensors and a permanent magnet显示文摘 | Schlageter V Besse P A Popovic R S | 2001 | Sensors and Actuators A-Physical2001，92，13： | 1 |
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