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| 1 | Comment on “Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics”显示文摘Attaran et al[1] have recently shown that decreased susceptibility of established Helicobacter pylori(H. pylori) biofilms to specific antibiotics,was associated with the overtly enhanced transcription of two efflux pump genes,hp1165 and hef A,involved in specific resistance to tetracycline and multiple antibiotics,respectively. Apart from antibiotic exposure,secretion of multiple antimicrobial peptides,such as human β-defensins(hβDs),by the gastric epithelium upon Hp challenge,may act as early triggering events that positively impact biofilm formation and thus,antibiotic resistance. In this regard,we undertook genomic transcriptional studies using Hp 26695 strain following exposure to sublethal,similar to those present in the gastric niche,concentrations of hβDs in an attempt to provide preliminary data regarding possible mechanisms of immune evasion and selective sensitivity of Hp. Our preliminary results indicate that hβD exposure ignites a rapid response that is largely due to the activation of several,possibly interconnected transcriptional regulatory networks – origons-that ultimately coordinate cellular processes needed to maintain homeostasis and successful adaptation of the bacterium in the gastric environment. In addition,we have shown that both antibiotic and hβD resistance are mediated by dedicated periplasmic transporters,including the aforementioned efflux pump genes hp1165 and hef A,involved in active export of antibiotics from the cell membrane and/or,as recently suggested,substrate sensing and signalling. Furthermore,itappears that sublethal doses of hβDs may enhance biofilm formation by the sustained expression of,mainly,quorum sensing-related genes. In conclusion,we provide additional data regarding the role of specific innate immune molecules in antibiotic cross-resistance mechanisms that may deepen our understanding in the context of the development of novel eradication regimens. | Evangelos I Kazakos Nick Dorrell Stergios A Polyzos Georgia Deretzi Jannis Kountouras | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 2 | A novel approach for analyzing open Z-scan experiments显示文摘 | Tsigaridas G Polyzos I Persephonis P | | 0，，01： | 1 |
| 3 | 显示文摘 | Tsigaridas G Fakis M Polyzos I | 2003 | Opt Commun2003，225，： | 1 |
| 4 | Early luteal phase endocrine profile is affected by the mode of triggering final oocyte maturation and the luteal phase support used in recombinant follicle-stimulating hor- mone-gonadotropin-releasing hormone antagonist in vitrofertilization cycles 显示文摘 | Fatemi H M Polyzos N P van Vaerenbergh I | 2013 | Fertil Steril2013，100，3： | 1 |
| 5 | Z-scan technique for elliptic Gaussian beams显示文摘 | TSIGARIDAS G FAKIS M POLYZOS I | 2003 | Appl Phys B2003，77，1： | 1 |
| 6 | Three-photon induced photobleaching in a three-dimensional memory material显示文摘 | Polyzos I Tsigaridas G Fakis M | 2005 | Optics Letters2005，30，19： | 1 |
| 7 | Serum bone turnover markers may be involved in the metastatic potential of lung cancer patients 显示文摘 | KARAPANAGIOTOU E M TERPOS E DILANA K D ALAMARA C GKIOZOS I POLYZOS A SYRIGOS KN | 2010 | Med Oncol2010，27，2： | 1 |
| 8 | Z-scan analysis for high nonlinearities through Gaussian decomposition显示文摘 | Tsigaridas G Fakis M Polyzos I | 2003 | Opt Commun2003，225，46： | 1 |
| 9 | Two-photon absorption properties of novel organic materials for three-dimensional op- tical memories显示文摘 | Polyzos I Tsigaridas G Fakis G | 2003 | Chemical Physics Letters2003，369，： | 1 |
| 10 | Three-photon induced photobleaching in a three-dimensional memory material 显示文摘 | Polyzos I Tsigaridas G Fakis M | 2005 | Optics Letters2005，38，19： | 1 |
| 11 | Phase I! study of gemcit- abine plus 5 - fluorouracil biologically modulated by folinic acid plus long - acting formulation of octreotide (LAR) in patients with advanced pancreatic cancer显示文摘 | Polyzos A Tsavaris N Vafiadis I | 2005 | J BUON2005，10，3： | 1 |
| 12 | Aromatase inhibitors in stimulated IVF cycles显示文摘 | i Evangelos G Papanikolaou Nikolaos P Polyzos Peter Humaidan | 2011 | Reproductive Biol- ogy and Endocrinology2011，9，1： | 1 |
| 13 | Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review显示文摘 | Polyzos NP Mauri D Tsappi M et I | 2007 | Obstet Gynecol Surv2007，62，： | 1 |
| 14 | Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta- analysis 显示文摘 | Polyzos N P Polyzos I P Zavos A | 2010 | British Medi- cal Journal2010，12，： | 1 |
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