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| 1 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 2 | Expression of cell-cycle related proteins in Helicobacter pylori gastritis and association with gastric carcinoma显示文摘 | Polat A Cinel L Dumsea D | 2002 | Neoplasma2002，49，2： | 1 |
| 3 | Bcl - 2,iN- OS, p53 and PCNA expression in normal, disordered proliferative, hyperplastic and malignant endometrium 显示文摘 | Cinel L Polat A Aydin O | 2002 | Pathol Int2002，52，： | 1 |
| 4 | Electrochemical behaviour of 1-{methyl}-2-naphthol Schiff bases on graphite electrodes显示文摘 | Polat K Ucar M Aksu M L et aL | 2004 | Can J Chem2004，82，： | 1 |
| 5 | Synthesis and characteriza- tion of water - dispersed flame - retardant polyurethane resin using phosphorus -containing chain extender显示文摘 | CELEBI F POLAT O ARAS L | 2005 | Reactive Polymers Fun- damentals and Applications2005，34，10： | 1 |
| 6 | Synthesis and charac- terization of water-dispersed flame-retardant polyurethane resin using phosphorus-containing chain extender显示文摘 | CELEBI F POLAT O ARAS L | 2004 | Journal of Applied Polymer Science2004，91，2： | 1 |
| 7 | Evalu-ation of genetic diversity in lemons and some of their relatives based on SRAP and SSR markers显示文摘 | UZUN A YESILOGLU T POLAT L AKA-KACAR Y GULSEN O YILDIRIM B TUZCU O TEPE S CANAN L ANIL S | 2011 | Plant Molecular Biology Reporter2011，29，3： | 1 |
| 8 | An in vitro study comparing the coagulation and cautery effects of bipolar and unipolar cutting modalities on prostatic tissue显示文摘 | Akgül T Nuhoglu B Polat O | 2009 | Urol Int2009，83，4： | 1 |
| 9 | Association between serum gamma - glutamyltransferase activity and carotid intima - media thickness显示文摘 | EROQLU S SADE L E POLAT E | 2011 | Angiology2011，62，2： | 1 |
| 10 | Expression of cell-cycle related proteins in Helicobacter pylori gastritis and association with gastric carcinoma显示文摘 | Polat A Cinel L Dusmez D | 2002 | Neoplasma2002，49，2： | 1 |
| 11 | Electroreduction of nitrobenzene to p-aminophenol using voltammetric:and semipilot scale preparative electrolysis techniques显示文摘 | POLAT K AKSU M L PEKEL A T | 2002 | J Appl Electrochem2002，32，： | 1 |
| 12 | Association between serum gamm-a-glutamyltransferase activity and carotid intima-media thickness显示文摘 | Eroglu S Sade L E Polat E | 2011 | Angiology2011，62，2： | 1 |
| 13 | Serum L-carnitine levels and lipoprotein compositions chronic viral hepatitis patients 显示文摘 | Eshandari GH Kandemir O Polat G Tamer L Ersoz G At U | 2001 | Clin Biochecn2001，，5： | 1 |
| 14 | Electroreduction of nitrobenzene to p-aminophenol using voltammetric and semipilot scale preparative electrolysis techniques显示文摘 | Polat K Aksu M L Pekel A T | 2002 | J Appl Electrochem2002，32，： | 1 |
| 15 | Electroreduction of nitrobenzene to p- arninophenol using voltammetric and semipilot scale preparative electrolysis techniques 显示文摘 | Polat K Aksu M L Pekel A T | 2002 | J Appl Electrochem2002，32，2： | 1 |
| 16 | Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis: serum levels and relationship to inflammation显示文摘 | Dursun Dursuno?lu Harun Evrengül Bülent Polat Halil Tanr?verdi Veli ?obankara Asuman Kaftan Mustafa K?l?? | 2005 | Rheumatology International2005，，4： | 1 |
| 17 | Synthesis and characterization of water-dispersed flame-retardant polyurethane resin using phosphorus- containing chain extender显示文摘 | CELEBI F POLAT O ARAS L | 2004 | Journal of Applied Polymer Science2004，91，： | 1 |
| 18 | Ultrasound-me- diated transdermal drug delivery: mechanisms, scope, and e- merging trends 显示文摘 | POLAT BE DOUGLAS H ROBERT L | 2011 | J Control Release2011，152，3： | 1 |
| 19 | Expression of cell-cycle related proteins in hellcobacter pylori gastritis and association with gastric carcinoma显示文摘 | Polat A Cinel L Dusmez D Aydin O | 2002 | Neoplasma2002，49，2： | 1 |
| 20 | Electroreduction of nitrobenzene to p-aminophenol using voltammetric and semipilot scale preparative electrolysis techniques显示文摘 | Polat K Aksu M L Pekel A T | 2002 | J Appl Electrochem2002，32，2： | 1 |
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