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| 1 | FragAnchor: A Large-Scale Predictor of Glycosylphosphatidylinositol Anchors in Eukaryote Protein Sequences by Qualitative Scoring显示文摘A glycosylphosphatidylinositol (GPI) anchor is a common but complex C-terminal post-translational modification of extracellular proteins in eukaryotes. Here we investigate the problem of correctly annotating GPI-anchored proteins for the growing number of sequences in public databases. We developed a computa- tional system, called FragAnchor, based on the tandem use of a neural net- work (NN) and a hidden Markov model (HMM). Firstly, NN selects potential GPI-anchored proteins in a dataset, then HMM parses these potential GPI sig- nals and refines the prediction by qualitative scoring. FragAnchor correctly predicted 91% of all the GPI-anchored proteins annotated in the Swiss-Prot database. In a large-scale analysis of 29 eukaryote proteomes, FragAnchor predicted that the percentage of highly probable GPI-anchored proteins is between 0.21% and 2.01%. The distinctive feature of FragAnchor, compared with other systems, is that it targets only the C-terminus of a protein, making it less sensitive to the background noise found in databases and possible incomplete protein sequences. Moreover, FragAnchor can be used to predict GPI-anchored proteins in all eukaryotes. Finally, by using qualitative scoring, the predictions combine both sensitivity and information content. The predictor is publicly available at http://gffzz1607d9a456694c4chqpvnkubqqp6n69qp.ffgz.tsg.suse.edu.cn/~fraganchor/NNHMM/NNHMM.html. | Guylaine Poisson Cedric Chauve Xin Chen Anne Bergeron | 2007 | Genomics, Proteomics & Bioinformatics2007，5，2： | 3 |
| 2 | Detection and measurement power quality disturbances using wavelet transform 显示文摘 | Olivier Poisson Pascal Rioual Michel Meunier | 2000 | IEEE Transaction on Power Delivery2000，15，3： | 2 |
| 3 | Detection and measurement of power quality disturbances using wavelet transform 显示文摘 | Poisson O Pascal Rioual Michel Meunier | 2000 | IEEE Transaction on Power Delivery2000，13，3： | 2 |
| 4 | Menin interacting proteins as clues the understanding of multiple endocrine neoplasia type 1显示文摘 | Zablewska B Gaudray P | 2003 | Cancer Lett2003，189，1： | 1 |
| 5 | AIInN/ AIN/GaN HEMT technology on SiC with 10 W/mm and 50% PAE at 10 GHz显示文摘 | Sarazin N Morvan E Poisson M A F | 2010 | IEEE Electron Device Lett2010，31，1： | 1 |
| 6 | Detection and measurement of power quality Disturbances using wavelet transform显示文摘 | Poisson O Rioual P Meunier M | 2000 | IEEE Transactions on Power Delivery2000，15，3： | 1 |
| 7 | Curing of dicyandiamide epoxy resins accelerated with substituted ureas显示文摘 | N Poisson A Maaz ouz H Sautereau | 1998 | Journal of Applied Polymer Science1998，69，： | 1 |
| 8 | High speed train noise emission: latest investigation of the aerodynamic/ rolling noise contribution显示文摘 | Mellet C Le tourneaux F Poisson F | 2006 | Journal of Sound and Vibration2006，293，55： | 1 |
| 9 | Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression 显示文摘 | Sreekumar A Poisson L M Rajendiran T M | 2009 | Nature2009，457，7231： | 1 |
| 10 | Les Chinois du Zhejiang en France显示文摘 | Poisson V | 1997 | Migrations Societe1997，9，54： | 1 |
| 11 | Eight - year results of randomized clinical trial comparing total mastectomy and lumpeetomy with or without irradiation in the traatment of breast cancer 显示文摘 | Fisher B Redmond C Poisson R | 1989 | N Engl J Med1989，320，13： | 1 |
| 12 | Detection and measurement of power quality disturbances using wavelet transofrm显示文摘 | Poisson O Rioual P Meunier M | 2000 | IEEE Trens on Power Delivery2000，15，3： | 1 |
| 13 | Corrigendum: metabolomic profiles delineate potential role for sarcosine in prostate cancer progression 显示文摘 | Sreekumar A Poisson LM Rajendiran TM | 2013 | Nature2013，457，7231： | 1 |
| 14 | Structure d' alealoi'des indoliques doubles d 'un type nouveau 显示文摘 | Kuneseh N Rolland Y Poisson J | 1977 | Helvetica Chimica Acta1977，60，8： | 1 |
| 15 | Radiative falloff in Schwarzschild-de Sitter spacetime显示文摘 | BRADY P R CHAMBERS C M LAARAKKERS W G POISSON E | 1999 | Phys Rev D1999，60，06： | 1 |
| 16 | Study on the roleof precursors in coffee flavor formation using in-bean experiments显示文摘 | Poisson L Schmalzried F Davidek T | 2009 | Journal of Agricultural and Food Chemistry2009，57，21： | 1 |
| 17 | Alkaloids From Leaves of Rauwolfia-Vomitoria - IdentiW of Vonfitbline With Peraksine显示文摘 | Pousset J L Debray M Poisson J | 1977 | Phytochhemistry1977，16，1： | 1 |
| 18 | 'Omics' data and levels of evidence for biomarker discovery显示文摘 | Ghosh D Poisson L M | 2009 | Genomics2009，93，： | 1 |
| 19 | Detection and measurement of power quality disturbances using wavelet transform显示文摘 | Poisson O Rioual P Meunier M | 2000 | IEEE Trans on Power Delivery2000，15，3： | 1 |
| 20 | ASSESSMENT OF THE ACOUSTICAL COMFORT IN HIGH-SPEED TRAINS AT THE SNCF: INTEGRATION OF SUBJECTIVE PARAMETERS显示文摘 | F. LéTOURNEAUX S. GUERRAND F. POISSON | 2000 | Journal of Sound and Vibration2000，，3： | 1 |
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