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| 1 | Crystal Structure of Loliolide (5, 6,7a-Tetrahydro-6-hydroxy-4, 4, 7a-trimethyl-2 (4H)-benzofuranones)显示文摘The structure of the title compound, which was isolated fromClinopodium polycephalum (Vant.) by C. Y. Wu et Hsuan, has been determined byX-ray diffraction analysis. C11H16O3, Mr= 196. The crystal belongs to the monoclinicspace group P21 with a= 6. 072 (3), b=11. 682 (5), c= 7. 865 (4) A, β= 109. 61(4)°, V=525. 5(4) , Z= 2, F(000) =212, Dc= 1.234 g/cm3, μ=0.08 mm-1.The structure was solved by direct methods and refined to R=0. 048 for 616 observedreflections. The molecule is composed of a six-membered ring and a five-membered lactone ring with a methyl and a hydroxy group at the two asymmetrical carbons locatedon the same side of the nucleus. | CHEN Jing-Yu CHEN Jian-Min XIAO Pei-Gen(Institute of Medicinal Plant Development, the Chinese Academy of Medical Sciences,Peking Union Medical College, Beijing 100094)WU Nan LU Yang(Institute of Materia Medica, the Chinese Academy of Medical Sciences,P | 1997 | Chinese Journal of Structural Chemistry1997，16，5： | 2 |
| 2 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Evaluation of surface compo- nents of Brucella ovis as antigens for the detection of preeipitin antibody in serums from artificially exposed rams显示文摘 | Chin J C Plant J W Claxton P D | 1983 | Aust Vet J1983，60，： | 1 |
| 4 | Structure of large arteries: Orientation of elastin in rabbit aortic internal elastic lamina and in the elastic lamellae of aortic media 显示文摘 | Farand P Garon A Plante G E | 2007 | Microvasc Res2007，73，： | 1 |
| 5 | Fundamental application study of lignin on plastics 显示文摘 | PLANTE P PIGEON M FOY C | 1999 | Cement and Concrete Research1999，19，4： | 1 |
| 6 | Object-based cropidentification using multiple vegetation indices, texturalfeatures and crop phenology显示文摘 | Barragdn P Ngugi J M Plant M K | 2011 | Remote Sensing of Environment2011，115，6： | 1 |
| 7 | Early use of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards:a multicenter randomized controlled trial显示文摘 | Plant P K Owen T L Elliott M W | 2000 | Lancet2000，355，： | 1 |
| 8 | Accelerating radio astronomy cross-correlation with graphics processing units 显示文摘 | Clark M A La Plante P C Greenhill L J | 2013 | International Journal of High Performance Computing Applications2013，27，2： | 1 |
| 9 | DNA vaccination against channel catfish virus results in minimal immune response and is not efficacious against challenge 显示文摘 | Harbottle H Plant K P Thune R L | 2005 | J Aquat Anim Health2005，17，3： | 1 |
| 10 | Existence of a microRNA pathway in anucleate platelets显示文摘 | Landry P Plante I Ouellet DL | 2009 | Nat Struct Mol Biol2009，16，9： | 1 |
| 11 | Identification of functional microRNAs released through asymmetrical processing of HIV-I TAR element显示文摘 | Ouellet D L Plante I Landry P | 2008 | Nucleic Acids Res2008，36，7： | 1 |
| 12 | Crystal structures and properties of denovo circularly permuted 1,3-1,4-Gulcanase显示文摘 | P Campbell J Braam Plant J | 1998 | J Sci Food Agr1998，15，： | 1 |
| 13 | CALEX/Cotton:an integrated expert system for cotton production and management显示文摘 | Goodell P B Plant R E Kerby T A | 1990 | California Agriculture1990，44，5： | 1 |
| 14 | 显示文摘 | PLANTE J P GLASS T E | 2006 | Org Lett2006，，8： | 1 |
| 15 | Novel Approach to Functionalised Pyridazinone Arrays 显示文摘 | HEIM D M PLANT A HARRITY P A J | 2006 | Org Biomol Chem2006，，4： | 1 |
| 16 | Existence of a microrna pathway in anucleate platelets显示文摘 | Landry P Plante I Ouellet DL | | 0，，： | 1 |
| 17 | Existence of a mieroRNA pathway in anueleate platelets显示文摘 | Landry P Plante I Ouellet DL | 2009 | Nat Struct Mol Biol2009，16，9： | 1 |
| 18 | The influence of water-reducers on the production and stability of the air void system in concrete显示文摘 | Plante P Pigeon M Foy C | 1989 | Cement and Concrete Research1989，19，4： | 1 |
| 19 | Role of eicosanoids in PAF-induced increases of the vascular permeability in rat airways显示文摘 | Plante GE Braquet P | 1990 | Br J Pharmcol1990，101，： | 1 |
| 20 | Microwave and acoustic scattering from parasitic capillary waves显示文摘 | Plant W J Dahl P H and Keller W C | 1999 | Journal of Geophysical Research-Oceans1999，104，25： | 1 |
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