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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Modification of the molar anionic charge density of acetone-formaldehyde-sulfite dispersant to improve adsorption behavior and effectiveness in the presence of cement fluid loss polymer 显示文摘 | Plank J Fatima D B Nils Recalde L | 2009 | Journal of Applied Polymer Science2009，111，4： | 1 |
| 3 | Randomized con- trolled trial of preoperative oral carbohydrate treatment in major abdominal s urgery显示文摘 | Mathur S Plank L D McCall J L | 2010 | Br J Surg2010，97，4： | 1 |
| 4 | Pre-and postoperative immunonutrition in patients undergoing liver transplantation:a pilot study of safety and efficacy显示文摘 | PLANK L D MCCALL L J GANE E J | 2005 | Clin Nutrition2005，4，24： | 1 |
| 5 | Central obesity and risk for type 2 diabetes in Maori, Pacific, and European young men in New Zealand显示文摘 | Rush E C Plank L D Mitchelson E | 2002 | Food Nut Bull2002，23，3： | 1 |
| 6 | Randomized controlled trial of preoperative oral carbohydrate treatment in major abdominal surgery显示文摘 | Mathur S Plank L D Mccall J L | | 0，，04： | 1 |
| 7 | Dry etching of SiC in inductively coupled Cl2/Ar plasma显示文摘 | JIANG L D PLANK N O V BLAUW M A | 2004 | J Phys:D2004，37，13： | 1 |
| 8 | Similarity of changes in body composition in intensive care patients following severe sepsis or major blunt injury显示文摘 | Plank L D Hill G L | 2000 | Ann N Y Acad Sci2000，904，： | 1 |
| 9 | Prolonged overexpansion of extracellular water in elderly patients with sepsis显示文摘 | Cheng A T Plank L D Hill G L | 1998 | Arch Surg1998，133，： | 1 |
| 10 | Fluorination of carbon nanotubes in CF4 plasma显示文摘 | Plank N O V Jiang L D Cheung R | 2003 | Appl Phys Lett2003，83，2： | 1 |
| 11 | Postsurgical infectionsare reduced with specialized nutrition support显示文摘 | Waitzberg D L Saito H Plank L D | 2006 | World J Surg2006，30，： | 1 |
| 12 | Fat mass is an important determinant of whole body bone density in premenopausal women but not in men显示文摘 | REID I R PLANK L D EVANS M C | 1992 | J Clin Endocrinol Metab1992，75，： | 1 |
| 13 | Dry etching of SiC in inductively coupled Cl2/Ar plasma 显示文摘 | JIANG L D PLANK N BLAUW M A | 2004 | J Phys D Appl Phys2004，37，13： | 1 |
| 14 | Body composition,muscle function,and energy expenditure in patients with liver cirrhosis:a comprehensive study 1-3,The American Journal of Clinical Nutrition显示文摘 | Szelin Peng Lindsay D Plank John L McCall | 2007 | 85:1257-12662007，85，： | 1 |
| 15 | Adult total parenteral nutrition at Auckland City Hospital: a 6-year review显示文摘 | Brokenshire E Plank L D Gillanders L K | 2009 | N Z Med J2009，122，1297： | 1 |
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