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| 1 | Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients显示文摘AIM: To analyze the correlation between cytokineinduced killer (CIK) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. METHODS: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model. RESULTS: The survival time of gastric cancer patients was longer after CIK cells adoptive immunotherapy than after chemotherapy (χ 2 = 10.907, P = 0.001). The median survival time of gastric cancer patients was also longer after CIK cells adoptive immunotherapy than after chemotherapy (49 mo vs 27 mo, P < 0.05). The 2- and 5-year survival rates of gastric cancer patients were significantly higher after CIK cells adoptive immunotherapy than after chemotherapy (73.5% vs 52.6%, 40.4% vs 23.9%, P < 0.05). A significant difference was observed in the survival curve for patients who received CIK cells adoptive immunotherapy (0, 1-10, 11-25, and over 25 frequencies) (χ 2 = 14.534, P = 0.002). The frequencies of CIK cells adoptive immunotherapy were significantly related with the decreasing risk of death in gastric cancer patients after adjustment for sex and age of the patients, tumor stage and relapse (HR = 0.54, 95% CI: 0.36-0.80) when the first stage Cox model was used to define the subjects who remained alive beyond 36 mo as survivors. However, no correlation was observed between the frequencies of death in CIK cells adoptive immunotherapy and the risk of gastric cancer patients (HR = 1.09, 95% CI: 0.63-0.89) when the second stage Cox model was used to define the subjects who survived for more than 36 mo as survivors. CONCLUSION: The survival time of the gastric cancer patients treated with chemotherapy combined with CIK cells adoptive immunotherapy is significantly longer than that of the patients treated with chemotherapy alone and increasing the frequency of CIK cells adoptive immunotherapy seems to benefit patients more. | Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States | 2010 | World Journal of Gastroenterology2010，16，48： | 82 |
| 2 | Signal transduction mediated by Bid,a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways显示文摘Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases. | YIN XIAO-MING (Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA) | 2000 | Cell Research2000，10，3： | 25 |
| 3 | Liver retransplantation: indications and outcomes显示文摘BACKGROUND: Liver transplantation is a life-saving the- rapeutic modality for patients with end-stage liver diseases. After liver transplantation, however, more than 10% pa- tients may lose the grafts caused by a variety of reasons. This review covers the most frequent indications for liver retransplantation as well as the results and specific problems with each indication. DATA RESOURCES: Searching MEDLINE (1997-2003) for articles on liver retransplantation. RESULTS: The most frequent indications of liver retrans- plantation are primary non-function, hepatic artery throm- bosis, graft rejection and recurrent diseases. The results af- ter liver retransplantation remain inferior to those after first transplantation. CONCLUSION: Liver retransplantation, which is the only means of prolonging survival in those patients whose initial graft has failed, makes an important contribution to overall survival. | Zi-Fa Wang and Chang Liu Pittsburgh, USA Department ot Surgery, University of Pittsburgh Me- dical Center, Pittsburgh, PA 15213, USA Division of Hepa- tobiliary Surgery . First Hospital, Xi’ an Jiaotong University , Xi’ an 710061, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 4 |
| 4 | The role of inflammatory mediators in severe acute pancreatitis and regulation of glucocorticoids显示文摘OBJECTIVE: To investigate the effect of glucocorticoids on systemic inflammatory mediator release inrats with acute pancreatitis and the outcome of dexamethasone in treatment of acute pancreatitis.METHODS: Sixty-eight Wistar rats were divided into sham, acute pancreatitis, and treatment(intravenous dexamethasone 0.5 mg/kg) groups. Experimental acute pancreatitis was induced by theinjection of 5% sodium taurocholate (0.1 ml/100 mg body weight) into the pancreatic-biliary duct. ThebIood samples were obtained and examined for 6-keto-PGI1α, TXB2 and IL-6 postoperatively at 3,6 and12 hours, respectively. The pancreatic samples were evaluated by a blinded method. Twelve-hour survivalrate was determined and compared between the groups.RESULTS: The high serum concentrations of 6-keto-PGI1α, TXB2 and IL-6 were noted in the rats withacute pancreatitis associated with pancreatic hemorrhage and necrosis. Their 12-hour survival rate was42.9%. The rats in the treatment group survived with significantly reduced serum concentrations of6-keto-PGI1α, TXB2 and IL-6 (P<0.05). Their pancreatic morphology was normal.CONCLUSION: Dexamethasone may reduce the serum concentration of 6-keto-PGI1α, TXB2, and IL-6,and the severity of acute pancreatitis while increasing the survival rate of rats with acute pancreatitis. | Zi-Fa Wang Cheng-En Pan Yi Lu Shao-Gao Liu Guan-Jun Zhang Xue-Bin Zhang the Departments of Surgery and Pathology First Hospital, Xi’an Jiaotong University, Xi’an 710061, China the Department of Surgery, University of Pittsburgh, NW607, Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，3： | 3 |
| 5 | Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved显示文摘Endothelial nitric oxide synthase (eNOS) is a key enzyme responsible for the regu-lation of vascular homeostasis. Many humor factors and mechanical forces can affect eNOS ac-tivity via phosphorylation modification but the mechanisms involved vary with stimuli applied. We have demonstrated that cytochrome P450 (CYP) epoxygenase-dependent metabolites of ara-chidonic acid, epoxyeicosatrienoic acids (EETs), can robustly up-regulate eNOS expression and its activity, however the relevant signaling pathways responsible for activity regulation are not well known. In this study, we explored the role of PI3 kinase (PI3K)/protein kinase B (Akt) sig-naling pathway in eNOS expression and its phosphorylation in response to EETs via direct addi-tion of EETs into cultured bovine aorta endothelial cells (BAECs) and recombinant adeno- asso-ciated virus-mediated transfection of CYP epoxygenase genes CYPF87V and CYP2C11 to pro-duce endogenous EETs followed by co-treatment with PI3K or Akt inhibitor. Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression. These results lead to conclusions: (i) EETs-mediated regulation of eNOS activity may be related with the changes of phosphoryla-tion level at eNOS-Ser1179 via PI3K/Akt and eNOS-Thr497 via Akt; (ii) PI3K/Akt signaling pathway is involved in the up-regulation of eNOS expression by EETs. | CHEN Ruijuan1, JIANG Jiangang1, XIAO Xiao2 & WANG Daowen1 1. The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China 2. Departments of Molecular Genetics and Biochemistry & Gene Therapy Center, University of Pittsburgh, Pittsburgh, PA, USA | 2005 | Science China(Life Sciences)2005，48，5： | 3 |
| 6 | Natural Killer cells and natural killer cells activity in chronic fatigue syndrome显示文摘 | Whitedise TL Friberg D Pittsburgh | 1998 | Ame J Med1998，105，3： | 2 |
| 7 | A Discrete Singular Integral Operator(In Memory of Professor Long Ruilin) | Fan Dashan (Department of Mathematical Sciences,University of Wisconsin-Milwaukee,Milwaukee,WI 53201,USA)(Email:fan@alpha1.csd.uwm.edu)Lu Shanzhen (Department of Mathematics,Beijing Normal University,Beijing 100875,China)(Email:lusz@sun.ihep.ac.cn)Pan Yibiao (Department of Mathematics and Statistics,University of Pittsburgh,Pittsburgh,PA 15260,USA)(Email:yibiao@tomato.math.pitt.edu) | 1998 | Acta Mathematica Sinica,English Series1998，14，2： | 1 |
| 8 | Australia Self-ligating brackets: Present and future 显示文摘 | Daniel J Rir/chusea and Peter G Milesb Pittsburgh Pa | 2007 | A- merican Association of Orthodontists2007，132，2： | 1 |
| 9 | Natural killer cwlls and natural killer cell activity in chronic fatigue syndrome显示文摘 | Whitedise TL Fribeg D Pittsburgh et el | 1998 | Am J Med1998，105，3： | 1 |
| 10 | 显示文摘 | | 1987 | Aviation Week and Space Technology1987，5，： | 1 |
| 11 | Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy显示文摘Elucidating the underlying mechanisms of cell physiology is currently an important research topic in life sciences. Atomic force microscopy methods can be used to investigate these molecular mechanisms. In this study, single-molecule force spectroscopy was used to explore the specific recognition between the CD20 antigen and anti-CD20 antibody Rituximab on B lymphoma cells under near-physiological conditions. The CD20-Rituximab specific binding force was measured through tip functionalization. Distribution of CD20 on the B lymphoma cells was visualized three-dimensionally. In addition, the relationship between the intramolecular force and the molecular extension of the CD20-Rituximab complex was analyzed under an external force. These results facilitate further investigation of the mechanism of Rituximab’s anti-cancer effect. | LI Mi1,5,6, LIU LianQing1*, XI Ning1,2*, WANG YueChao1, DONG ZaiLi1, LI GuangYong1,3, XIAO XiuBin4 & ZHANG WeiJing4* 1State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 2Department of Electrical and Computer Engineering, Michigan State University, East Lansing 48824, USA 3Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh 15261, USA 4Department of Lymphoma Affiliated Hospital of Military Medical Academy of Sciences, Beijing 100071, China 5Graduate University of Chinese Academy of Sciences, Beijing 100049, China 6State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China | 2010 | Science China(Life Sciences)2010，53，10： | 1 |
| 12 | A CONSTITUTIVE THEORY FOR THE REYNOLDS-STRESS CLOSURES IN TURBULENCE MODELLING显示文摘ACONSTITUTIVETHEORYFORTHEREYNOLDS-STRESSCLOSURESINTURBULENCEMODELLING￥L.Y.Tao,(DepartmentofMechanicalEngineering,Universityof... | L. Y. Tao,(Department of Mechanical Engineering, University of Pittsburgh, PA15261,USA)G. Q. Chen(Centre for Environmental Sciences, Peking University, Beijing 100871,P. R. China)K. R. Rajagopal(Department of Mechanical Engineering, University of Pittsbur | 1996 | Journal of Hydrodynamics1996，8，1： | 1 |
| 13 | Emergency medicine in China 显示文摘 | ROBBIE ALL PITTSBURGH | 2001 | J Emerg Med2001，21，2： | 1 |
| 14 | A unity-power-factor IPT pickup for high-power applications显示文摘 | Energy Conversion Congress and 14-18 2014 Pittsburgh PA USA KEELING N A BOYS J T COVIC G A | 2010 | IEEE Trans on Industrial Electronics2010，57，2： | 1 |
| 15 | Natural killer cells and natural killer cell activity in chronic fatigue syndrome显示文摘 | Whitedise TL Fribeg D Pittsburgh | 1998 | Am J Med1998，105，3： | 1 |
| 16 | hot strip mill显示文摘 | KELLER N L LESONICK M S:Vibration analysis of stand F2 of wheeling- pittsburgh's 80-In | 1990 | Iron and Steel Engineer1990，67，5： | 1 |
| 17 | Multipurpose processing system and method for the beneficial use and management of sludge显示文摘 | Cummings James B Pittsburgh | 2000 | Patent Abstracts2000，64，： | 1 |
| 18 | Synthesis of Novel Chiral Diol Ligands for the Enantioselective Reactions显示文摘A series of novel enantiomerically pure diols were synthesized from D-erythorbic acid in three steps, and the absolute configuration of one of them 4a has been confirmed by X-ray analysis. | Ming Xia LI1, Yan Ming WANG 2, Ru Ru CHEN1* 1Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071 2Pittsburgh University Medical Center, Pittsburgh, PA 15213, U. S. A | 2001 | Chinese Chemical Letters2001，12，6： | 0 |
| 19 | NUMERICAL STURDY OF GRAVITATIONAL GRANULAR FLOW显示文摘The mechanics of flowing granular materials such as coal,sand, metal ores etc. , has received considerable attention in the recent years as it has relevance to several important technological problems. The governing equations for the flow of granular materials, are derived using a model based on the kinetic theory approach [cf. Boyle and Mas-soudi (1990)]. For a fully developed flow of these meterials down an inclined plane, the equations reduce to a system of coupled non-linear ordinary differential equations. The resulting boundary value problem is solved numerically and a parametric study is carried out to delineate how the various non-dimensional parameters affect the structure of the solution. | K. R. RajagopalDepartment of Mechanical Engineering, University of Pittsburgh, PA15261 ,USA(G. Q.ChenCentre for Environmental Sciences, Peking University, Beijing 100871,P. R. ChinaR. RamaDepartment of Mechanical Engineering, University of Pittsburgh, PAl5261 ,USA | 1997 | Journal of Hydrodynamics1997，9，3： | 0 |
| 20 | 品尝苹果与亚洲风味显示文摘探索一个热门的苹果之旅和一个超大型亚洲购物中心宾夕法尼亚州的一条苹果观光路线说到苹果,只有少数几个州能够胜过宾州。单是去年,宾州就生产了5.56亿磅苹果,这些苹果来自数千个果园,其中种植的品种约有100种,包括最受欢迎的像是金冠苹果与国王苹果这类的传统品种,还有像是蜜脆苹果这类比较新的品种。 | Pittsburgh Post-Gazette Nicole Norfleet | 2023 | 空中英语教室(高级版.彭蒙惠英语)2023，，6： | 0 |
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