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| 1 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 2 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 3 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 4 | 改变进气门相位对进气充量的影响显示文摘活塞与进气门交互运动产生的压力波会沿整个进气管传播,这种压力波能适当增加进入发动机气缸的进气质量。进行了改变进气门相位的试验研究,目的是分析它对进气充量的影响。‘试验在一台1. O L,16气门、每缸?,个进气门的产品发动机上进行。先在气流试验台上进行模拟发动机进气流状况的初步试验,然后再在测功器上进行发动机试验。气流试验台测试结果显示,在300CaA范围内改变进气相位角能使进气质量增加。发动机台架试验的结果是在进气门比原来气门开启相位迟开7. 50CaA的情况下测得的。 | Pereira L V M Pires L B M Pinto A A 李慧萍 | 2005 | 国外内燃机2005，37，6： | 2 |
| 5 | A Real Options Approach to Ship Investment Appraisal 显示文摘 | PIRES F C M ASSIS L F FIHO M R | 2012 | African Journal of Business Management2012，6，25： | 1 |
| 6 | A colorimetric biosensor for the detection of foodborne bacteria显示文摘 | PIRES A C S SOARESA N F F SILVA L H M | | 0，，01： | 1 |
| 7 | Carrier freezeout in silicon 显示文摘 | Pires R G Dickstein R M Titcomb S L | 1990 | Cryogenics1990，30，： | 1 |
| 8 | Drug-eluting stents:Results,promises and problems显示文摘 | van der Hoeven B L Pires N M M Warda H M | 2005 | Int J Cardiology2005，99，1： | 1 |
| 9 | Consequences of nitric oxide synthase inhibition during bovine oocyte maturation on meiosis and embryo development显示文摘 | Schwarz K R L Pires P R L De Bem T H C | 2010 | Reproduction in Domestic Animals2010，45，1： | 1 |
| 10 | Characterization of absorbent materials supported on polyurethane foams by nitrogen and toluene adsorption显示文摘 | PINTO M L PIRES J CARVALHO A P | 2005 | Microporous and Mesoporous Materials2005，80，123： | 1 |
| 11 | Aqueous-phase reforming of glycerol using Ni-Cu catalysts prepared from hydrotalcite-like precursors显示文摘 | Manfro R L Pires T P M D Ribeiro N F P | | 0，，： | 1 |
| 12 | Fatigue Be- haviour of Laser Repairing Welded Joints 显示文摘 | BORREGO L P PIRES J T B COSTA J M | 2007 | Engineering Failure Analysis2007，14，： | 1 |
| 13 | Prevalence of human papillomavirus in breast cancer: a systematic review显示文摘 | Simoes P W Medeiros L R Simoes Pires P D | 2012 | Int J Gynecol Cancer2012，22，3： | 1 |
| 14 | Parathyroidectomy improves survival in patients with severe hyperparathyroidism: a comparative study显示文摘 | Go|denstein PT Elias RM Pires de Freitas do Carmo L | 2013 | PLoS One2013，8，68： | 1 |
| 15 | Bayesian networks applied to failure diagnosis in power transformer显示文摘 | Quispe Carita A J Cambraia Leite L Pires Medeiros A P | 2013 | IEEE Latin America Transactions (Revista IEEE America Latina)2013，11，4： | 1 |
| 16 | Iteratively reweighted least-squares state estamation through givens rotations 显示文摘 | Pires R C Costa A S Mili L | 1999 | IEEE Transactions on Power Systems1999，14，4： | 1 |
| 17 | Cyclohexane oxidation over rare earth exchanged zeolite Y显示文摘 | Pires E L Wallau M Schuchardt U | 1998 | Journal of Molecular catalysis A: Chemical1998，136，： | 1 |
| 18 | Understanding mechanisms of novel gene expression in polyploids显示文摘 | OSBORN T C PIRES J C BIRCHLER J A AUGER D L CHEN Z J LEE H S COMAI L MADLUNG A DOERGE R W COLOT V MARTIENSSE R A | 2003 | Trends in Genetics2003，19，3： | 1 |
| 19 | Retinal thickness in eyes with mild nonproliferative retinopathy in patients with type 2 diabetes mellitus: comparison of measurements obtained by retinal thickness analysis and optical coherence tomography 显示文摘 | Pires I Bernardes R C Loho C L | 2002 | Arch Ophthalmol2002，120，10： | 1 |
| 20 | Cacao breeding in Bahia, Brazil-strategies and results显示文摘 | Lopes U V Monteiro W R Pires J L et ol | 2011 | Crop Breed Appl Biotechnol2011，11，1： | 1 |
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