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| 1 | 抗结核药物肝毒性反应的危险因素及其影响显示文摘背景:肝毒性反应是抗结核药物(下简称ATD)最严重的不良反应之一。虽然已有许多关于肝毒性反应危险因素的报道,但关于肝毒性反应严重程度的影响尚无系统研究。目的:评估肝毒性反应的危险因素(包括高龄、慢性肝病、酗酒或滥用药物或营养不良)对ATD所致肝毒性反应严重性的影响。设计:对1998年1月至2002年7月期间在结核科门诊接受异烟肼、利福平、吡嗪酰胺治疗的471例活动性结核病人进行前瞻性队列分析。根据ATD所致肝毒性反应危险因素的暴露情况评价肝毒性反应的发生率及其严重性。结果:危险因素暴露组ATD所致肝毒性反应(血清转氨酶>3倍的正常上限值)的发生率为18.2%(42/231例),而对照组为5.8%(14/240例),(OR=3.5;95%CI:1.9-6.7;P<0.001)。暴露组的严重肝毒性反应(血清转氨酶>10倍的正常上限值)发生率为6.9%(16/231),而对照组为0.4%(1/240)(OR=17.7;95%CI:2.3-135;P<0.001)。结论:肝毒性反应危险因素暴露组病人的ATD所致肝炎显著多见且较为严重。 | A. Fernández-Villar B. Sopena J. Fernández-Villar R. Vázquez-Gallardo F. Ulloa V. Leiro M. Mosteiro L. Pineiro 马玙 | 2005 | 结核与肺部疾病杂志2005，8，1： | 13 |
| 2 | Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro:dexamethasone and estradiol stimulate leptin release inwomen,but not in men显示文摘 | Casabiell X Pineiro V Peino R | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 3 | Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake 显示文摘 | CASABIELL X PINEIRO V TOME M A | 1997 | J Clin Endocrinol Metab1997，82，12： | 1 |
| 4 | Soil and tree responses to the application of wood ash containing charcoal in two soils with contrasting properties显示文摘 | Beatriz O Pineiro V Merino A | 2013 | Forest Ecology and Management2013，，295： | 1 |
| 5 | Leptin,reproduction and sex steroids显示文摘 | Casabiell X Pineiro V Vega F | 2001 | Pituitary2001，4，12： | 1 |
| 6 | Inhibition of chemi- cal changes related to freshness loss during storage of horse mackerel (Trachurus trachurus)in slurry ice 显示文摘 | Losada V Pineiro C Velazquez J B | 2005 | Food Chemis try2005，93，4： | 1 |
| 7 | Trace metals in marine foodstuff: bioavailability es- timation and effect of major food constituents 显示文摘 | MOREDA PINEIRO J MOREDA PINEIRO A ROMARIS HOR- TA V | 2012 | Food Chem2012，134，1： | 1 |
| 8 | Inhibition of chemical changes related to freshness loss during storage of horse mackerel (Trachurus trachurus) in slurry ice显示文摘 | Losada V Pineiro C Barros-Velzquez J | 2005 | Food Chemistry2005，93，4： | 1 |
| 9 | Presence of leptin in the regulation of neonatal food intake显示文摘 | CASABIELL X PINEIRO V TOME M | 1997 | J Clin Endocrinol Metab1997，82，12： | 1 |
| 10 | Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women,but not in men显示文摘 | Casabiell X Pineiro V Peino R | 1998 | J Clin Endocfinal Metab1998，83，6： | 1 |
| 11 | Presence of leptin in colostrums and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake 显示文摘 | Casabiell X Pineiro V Tome M A | 1997 | Endocrinal Metab1997，82，： | 1 |
| 12 | Leptin, reproduction and sex steroids显示文摘 | Casabiell X Pineiro V Vega F | 2001 | Pituitary2001，4，12： | 1 |
| 13 | Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in woman,but not in man显示文摘 | Casabiell X Pineiro V Peino R | 1998 | J Clin Endocrinal Metab1998，83，： | 1 |
| 14 | Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro:dexamethasone and estradiol stimulate leptin release in woman,but not in man显示文摘 | Casabiell X Pineiro V Peino R | 1998 | J Clin Endocrinal Metab1998，83，6： | 1 |
| 15 | Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate Leptin release in women,but not in men显示文摘 | Casabiell X Pineiro V Peino R | 1998 | J Clin Endocrinol Metab1998，83，6： | 1 |
| 16 | Inhibition of chemical changes related to freshness loss during storage of horse mackerel (Trachurus trachurus) in slurry ice显示文摘 | Losada V Pineiro C Barros-Velazquez J | 2005 | Food Chemistry2005，93，4： | 1 |
| 17 | Presence of leptin incolostrum and/or breast milk from lactating mothers: a potential rolein the regulation of neonatal food intake显示文摘 | Casabiell X Pineiro V Tome M | 1997 | J Clin EndocrinolMetab1997，82，12： | 1 |
| 18 | Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro:dexameshasone and estradiol stimulate leptin release in women,but not in men显示文摘 | Casabiell X Pineiro V Peino R | 1998 | J Clin Endocrinol Metab1998，83，6： | 1 |
| 19 | Inhibition of chemical changes related to freshness loss during storage of horse mackerel(Trachurus trachurus) in slurry ice显示文摘 | LOSADA V PINEIRO C BARROS-VELAZQUEZ J | 2005 | Food Chemistry2005，93，4： | 1 |
| 20 | Vascular wall:Potential target for the physicochemical effects of cis-unsaturated free fatty acids显示文摘 | Perez FR Pineiro V De La Cruz LF | | 0，，： | 1 |
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