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| 1 | Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil显示文摘AIM: To establish whether virulence factor genes vacA and cagA are present in Helicobacter pylori (H. pylori) retrieved from gastric mucosa and dental plaque in pa-tients with dyspepsia. METHODS: Cumulative dental plaque specimens and gastric biopsies were submitted to histological exami-nation, rapid urease test and polymerase chain reac-tion (PCR) assays to detect the presence of cagA and vacA polymorphisms.RESULTS: Detection of H. pylori from dental plaque and gastric biopsy samples was greater by PCR com-pared to histological examination and the rapid ure-ase test. DNA from H. pylori was detected in 96% of gastric mucosa samples and in 72% of dental plaque samples. Sixty-three (89%) of 71 dental plaque sam-ples that were H. pylori-positive also exhibited identical vacA and cagA genotypes in gastric mucosa. The most common genotype was vacAs1bm1 and cagA positive, either in dental plaque or gastric mucosa. These viru-lent H. pylori isolates were involved in the severity of clinical outcome.CONCLUSION: These pathogenic strains were found simultaneously in dental plaque and gastric mucosa, which suggests that gastric infection is correlated with the presence of H. pylori in the mouth. | Mnica Baraúna Assumpo Luisa Caricio Martins Hivana Patricia Melo Barbosa Katarine Antonia dos Santos Barile Sintia Silva de Almeida Paulo Pimentel Assumpo Tereza Cristina de Oliveira Corvelo | 2010 | World Journal of Gastroenterology2010，16，24： | 29 |
| 2 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 3 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 4 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 5 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 6 | A new rat model links two contemporary theories in irritable bowel syndrome显示文摘 | Pimentel M Chatterjee S Chang C | 2008 | Dig Dis Sci2008，53，4： | 1 |
| 7 | Eradication of small intestinalbacterial overgrowth reduces symptoms of irritable bowel syndrome显示文摘 | PIMENTEL M CHOW E J LIN H C | 2000 | The American Journal of Gastroenterology2000，95，12： | 1 |
| 8 | The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness:an observational cohort study显示文摘 | SALCICCIOLI J D MARSHALL D C PIMENTEL M A | 2015 | Crit Care2015，19，： | 1 |
| 9 | Phenol degrada- tion by advanced electrochemical oxidation process elec- tro-Fenton using a carbon felt cathode显示文摘 | Pimentel M Oturan N Dezotti M | 2008 | Applied Cataly- sis B: Environmental2008，83，12： | 1 |
| 10 | Eradication of small intenstnal bacterial over growth reduces symptoms of irritable bowel syndrome显示文摘 | Pimentel M choe EJ | 2000 | Am J Gastroen terol2000，95，： | 1 |
| 11 | Primary Adrenal Lymphoma Associated with Adrenal Insufficiency:A Distinct Clinical Entity显示文摘 | Johnston JB Allan DR | 1997 | Leukemia and Lymphoma1997，24，34： | 1 |
| 12 | Se-quence and function of lysosomal and digestive cathepsin D-likeproteinases of Musca domestica midgut显示文摘 | PADILHA M H PIMENTEL A C RIBEIRO A F | 2009 | Insect Biochem MolBiol2009，39，11： | 1 |
| 13 | Bacteria and Irritable Bowel Syndrome: the Evidence for Small Intestinal Bacterial Overgrowth显示文摘 | Lee H R Pimentel M | 2006 | Curr Gastroenterol Rep2006，8，30： | 1 |
| 14 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，： | 1 |
| 15 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel D R | 2004 | Circ Res2004，94，： | 1 |
| 16 | A 142 day elemental diet is highly effective in normali- zing the lactul osebreath test显示文摘 | PIMENTEL M CONSTANTINO T KONG Y | 2004 | Dig Dis Sci2004，49，： | 1 |
| 17 | Applied Catalysis B: Environmental 显示文摘 | Pimentel M Oturan N | 2008 | 83 (1-2):140-1492008，83，12： | 1 |
| 18 | Downregulation of transient receptor potential melastatin 8by protein kinase C mediated dephosphorylation显示文摘 | Premkumar L S Raisinghani M Pingle S C Long C Pimentel F | 2005 | J Neurosci2005，25，11： | 1 |
| 19 | Normalization of lactulose breath testing correlates with symptom improvement:in irritable bowel syndrome : a double - blind randomized, placebo controlled study显示文摘 | PIMENTEL M CHOW E J LIN HC | 2003 | Am J Gastroenterology2003，98，2： | 1 |
| 20 | Human amyloidogenic chains directly impair cardiomyocyte function through an increase in cellular oxidant stress显示文摘 | Brenner DA Jain M Pimentel DR | 2004 | Circ Res2004，94，： | 1 |
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