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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Determining Economic Contributions in a Recreational Industry: An Application to Colorado 's Golf Industry 显示文摘 | PHILIP W STEVE D DAWN T | 2008 | Journal of Sports Economics2008，9，6： | 1 |
| 3 | Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease显示文摘 | WILLIAM D T STEPHEN F PHILIP A | 2007 | Candian Medical Association Journal2007，177，11： | 1 |
| 4 | Identification and distruption of the gene encoding the k-activated acetaldehyde dehydrogenase of Saccharomyces cerevisiae 显示文摘 | Wayne D T Philip G M | 1998 | FEMS Microbiology Letters1998，164，： | 1 |
| 5 | Detection of adulteration of California orange juice concentrates with externally added carotenoids by liquid chromatography显示文摘 | PHILIP T CHEN T S & NELSON D B | 1989 | J Agric Food Chem1989，37，1： | 1 |
| 6 | Supply chain integration in vendor - managed inventory 显示文摘 | YAO Y L PHILIP T E MARTIN E D | 2007 | Deci- sion Support Systems2007，43，2： | 1 |
| 7 | Reservoir fracture mapping using microearthquakes:Two oilfield case studies显示文摘 | Philips W S Rutledge J T Faibanks T D | 1998 | Reservoir Evaluation &Engineering1998，114，121： | 1 |
| 8 | Adiponectin expression from human adipose tissue:relation to obesity,insulin resistance and tumor necrosis-α expression显示文摘 | Philip KG Gregorio D Lu T | 2003 | Diabetes2003，52，7： | 1 |
| 9 | Prevention of aflatoxieosis by addition of hydrated sodium calcium aluminositicate to the diets of growing barrows显示文摘 | Harvey R B Kubena L F Philips T D Huff W E Corrier D E | 1989 | Am J Vet Res1989，50，： | 1 |
| 10 | Real-time control of multi-product bulk-service semiconductor manufacturing processes 显示文摘 | FOWLER J W PHILIPS D T HOGG G L | 1992 | IEEE Transactions on Semiconductor Manufacturing1992，5，2： | 1 |
| 11 | Adiponectin expression from human adipose tissue:relation to obesity,insulin resistance and tumour necrosis-α expression显示文摘 | Philip K Gregorio D Lu T | 2003 | Diabetes2003，52，： | 1 |
| 12 | Characterization of petroleum source rocks and shales by pyrolysis-gas chromatography-mass spectrometry-multiple ion detection显示文摘 | Philip R P Gilbert T D | 1984 | Organic Geochemistry1984，6，： | 1 |
| 13 | Effect of peanut tannin extracts on growth of Aspergillus parasticus and aflatoxin production 显示文摘 | Pettit R E Sarr B A Philips T D | 1990 | Mycopathologia1990，110，3： | 1 |
| 14 | Modeling competitive adsorption of mixtures of volatile organic compounds in a fixed-bed of beaded activated carbon显示文摘 | TEFERA D T HASHISHO Z PHILIPS J H | 2014 | Environmental Science & Technology2014，48，9： | 1 |
| 15 | Age differences in safety attitudes and safety performance in Hongkong construction workers显示文摘 | Siu O Philips D Leung T | 2003 | Journal of Safety Research2003，34，2： | 1 |
| 16 | Biomarker distributions in Australian oils predominantly derived from terrigenous source material显示文摘 | PHILIP R P GILBERT T D | 1986 | Organic Geochemistry1986，10，13： | 1 |
| 17 | New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects显示文摘 | Alimuddin I Zumla Stephen H Gillespie Michael Hoelscher Patrick P J Philips Stewart T Cole Ibrahim Abubakar Timothy D McHugh Marco Schito Markus Maeurer Andrew J Nunn | 2014 | The Lancet Infectious Diseases2014，，4： | 1 |
| 18 | Effect of peanut tannin extacts on growth of Aspergillus parasticus and aflatoxin production显示文摘 | Azaizen A K Pettit R E Sarr B A Philips T D | 1990 | Mycopathologia1990，110，3： | 1 |
| 19 | Catalysis of lignite char gasification by exchangeable calcium and magnesium 显示文摘 | Hengel T D Philip L Walker Jr | 1984 | Fuel1984，63，9： | 1 |
| 20 | Real time control of multi-product bulk service semiconductor manufacturing process显示文摘 | FOWLER J W PHILIPS D T HOGG G L | 1992 | IEEE Transactions on Semiconductor Manufacturing1992，5，2： | 1 |
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