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55篇 您的检索式:作者名="PETZOLD H"
    题名 作者 年代 出处 被引量
1星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 2019神经损伤与功能重建2019,14,6:2
2Untersuchungen uber einen obligat parasitishen mikroorganismus mit lyticher aktivitat fur Pseudomonas bakterien显示文摘Stolp H Petzold H 1962Phytopathology1962,45,:1
3Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT显示文摘SRISKANDAKUMAR T PETZOLD H BRUIJNINCX P C 2009J Am Chem Soc2009,131,13:1
4Rapid prototyping technology in medicine-basic and applications显示文摘Petzold R Zeihofer H Kalender W A 1999Computerized Medical Imaging and Graphics1999,23,5:1
5Seeding of human vascular cells onto small diameter polyurethane vascular grafts 显示文摘Gulbins H Pritisanac A Dauner M Petzold R Goldemund A Doser M 2006Thorac Cardiovasc Surg2006,54,2:1
6A low-flow adaptation phase improves shear-stress resistance of artificially seeded endothelial cells显示文摘Gulbins H Pritisanac A Petzold R 2005Thorac Cardiovasc Surg2005,53,2:1
7Preservation of the mitral subvalvular apparatus in multiple valve procedures 显示文摘Straubu J Huwer H Petzold T 1997J Heart Valve Dis1997,4,5:1
8Effect of choline chloride and(-)-carnitine of the experimental fatty liver in the rat显示文摘Petzold H Schmidt C 0,,05:1
9Preparation and characterization of different polyelectrolyte complexes and their application as flocculants显示文摘Petzold G Nebel A Buchhammer H M 1998Colloid Polymer Science1998,276,:1
10Untersuchungen uber einen obtigat para sititischen microorganismus mit lytischer aktivitat furPseu domonas bakterien显示文摘Stolp H Petzold H 1962Phytopathol1962,45,:1
11Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease 显示文摘Petzold A Jenkins R Watt H C 2003Neurosci Lett2003,336,3:1
12Undersuchungen ubereigen obligat parasi- tischen mikroorganismus mit lytiseher aktivitat fur Pseudo- monas-bacterien显示文摘Stolp H Petzold H 1962Phytopathol Z1962,45,4:1
13Fault location in low-voltage electricity distribution networks 显示文摘SCHLAPP H PETZOLD F 2003Electrizitaetswirtschaft2003,102,9:1
14Undersuchungen ubereigen obligat parasitischen Mikroorganismus mit lytischer Aktivitat fur Pseudomonasbacterien显示文摘Stolp H Petzold H 1962Phytopathol Z1962,45,4:1
15Petzold H Undersuchungen ubereigen obligat parasitischen Mikroorganismus mit lytischer Aktivitat fur Pseudomonas-bacterien显示文摘Stolp H Petzold H 1962Phytopathol Z1962,45,4:1
16Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02,a new aqueous nasal spray显示文摘DERENDORF H MUNZEL U PETZOLD U 2012Br J Clin Pharmacol2012,74,:1
17Intranasal treament of perennial allergic rhinitis显示文摘Gastpar H Acerich R Petzold U Dorow P Enmann H Gering R Kochy HP Philipp A Renz W Wendenburg G 1993Drug Res1993,43,1:1
18Development of anartificial vessel lined with human vascular cells显示文摘Gulbins H Dauner M Petzold R 2004J Thorac Cardio Vasc Surg2004,128,3:1
19Advanced solution for on-site diagnosis of distribution power cables显示文摘PETZOLD F SCHLAPP H GULSKI E 2008IEEE Transactions on Dielectrics and Electrical Insulation2008,15,6:1
20Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray显示文摘Derendorf H Munzel U Petzold U 2012Br J Clin Phar- macl2012,74,1:1
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