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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 4 | Investigation of volatile organic compounds(VOCs) emission beyond the territory of oil terminals during different seasons显示文摘 | TATJANA P VYTENIS Z PETRAS V | 2011 | Journal of Environmental Engineering and Landscape Management2011，19，1： | 1 |
| 5 | l The clinical relevance of the fluid balance in critically illpatients显示文摘 | Petra ovicováI Sklienka P KolorL et a | 2000 | CriticalCare2000，4，1： | 1 |
| 6 | Nelfinavir,an HIV pro- tease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mi- tochondrial pathway 显示文摘 | Tong X Lanying D Petra P | 2015 | Cancer Letters2015，364，1： | 1 |
| 7 | Familial papillary carcinoma genetics criteria for diagnosis clinical features and surgical treatment显示文摘 | Petra BM Thorsten P | 2000 | World J Surg2000，24，11： | 1 |
| 8 | Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during α-interferon treatment显示文摘 | Georgios N Dalekos Heiner Wedemeyer Petra Obermayer-Straub Anne Kayser Ayse Barut Hannah Frank Michael P Manns | 1999 | Journal of Hepatology1999，，3： | 1 |
| 9 | Detection of differential gene expression in biofilm-forming versus planktonic populations of Staphylococcus aureus using microrepresintational-difference analysis显示文摘 | Petra B Georg P | 2001 | Appl Environ Mierobiol2001，67，7： | 1 |
| 10 | R-AIIyl Nickel( 11 ) complexes with chelating N-Heteroeyclic carbenes:synthesis, structural characterization and catalytic activity显示文摘 | JUNQUERA B L PETRA C M VALERGA P | 2012 | Organometallics2012，31，6： | 1 |
| 11 | Magnetic properties of metallic ferromagnetic nanoparticle composites 显示文摘 | RAMPRASAD R ZURCHER P PETRA M | 2004 | J Appl Phys2004，96，1： | 1 |
| 12 | Epizootiological aspects of Streptococcus iniae affecting tilapia in Texas显示文摘 | Petra R P Johnson S K Lenis D H | 1997 | Aquac1997，152，14： | 1 |
| 13 | Polyethylene multiwalled carbon nanotube composites显示文摘 | Tony McNally Petra P/tschke Peter Halley et aL | 2005 | Polymer2005，46，： | 1 |
| 14 | Heart rate decelera- tion runs for postinfarction risk prediction 显示文摘 | Przemyslaw G Jaroslaw P Petra 13 et ai | 2012 | Journal of Elec- trocardiology2012，45，1： | 1 |
| 15 | A correlative study of chnieal and histological findings of revision hip arthroplasty for rheumatoid arthritis and inflammatory joint disease 显示文摘 | Petra M Diaz J McLardy-Smith P | 2003 | Scand J Rheumatol2003，32，5： | 1 |
| 16 | Structural incorporation of Cm(Ⅲ) in trioctahedral smectite hectorite: A time-resolved laser fluorescence spectroscopy (TRLFS) study 显示文摘 | HEIKE B DIRK B PETRA J P | 2007 | Geochim Cosmochim Acta2007，71，1： | 1 |
| 17 | 显示文摘 | Petra P Mahrnoud A Ingo A | 2004 | Polymer2004，45，11： | 1 |
| 18 | X-ray powder diffraction quantitative analysis performed in situ at high temperature: Application to the determination of NiO in ceramic pigments 显示文摘 | GUALTIERI A F MAZZUCATO E VENTURELLI P VIANI A ZANNINI P PETRAS L | 1999 | Journal of Applied Crystallography1999，32，： | 1 |
| 19 | Liquid sensing properties of fibres prepared by melt spinning from poly(lactic acid) containing multi-walled carbon nanotubes显示文摘 | Petra P(o)tschke Timo Andres Tobias Villmow | 2010 | Compos Sci Techn2010，70，2： | 1 |
| 20 | Min CDE exploits the dynamic nature of Fts Z filaments for its spatial regulation显示文摘 | ARUMUGAM S PETRA EK Z SCHWILLE P | 2014 | PNAS2014，111，13： | 1 |
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