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| 1 | Current status of clinical islet transplantation显示文摘Islet transplantation(IT) is today a well-established treatment modality for selected patients with type 1 diabetes mellitus(T1DM). After the success of the University of Alberta group with a modified approach to the immune protection of islets, the international experience grew along with the numbers of transplants in highly specialized centers. Yet, long-term analysis of those initial results from the Edmonton group indicated that insulin-independence was not durable and most patients return to modest amounts of insulin around the fifth year, without recurrent hypoglycemia events. Many phenomena have been identified as limiting factor for the islet engraftment and survival, and today all efforts are aimed to improve the quality of islets and their engrafting process, as well as more optimized immunosuppression to facilitate tolerance and ultimately, better long term survival. This brief overview presents recent progress in IT. A concise historical perspective is provided, along with the latest efforts to improve islet engraftment, immune protection and ultimately, prolonged graft survival. It is apparent that as the community continues to work together further optimizing IT, it is hopeful a cure for T1 DM will soon be achievable. | Andrew R Pepper Boris Gala-Lopez Oliver Ziff AM James Shapiro | 2013 | World Journal of Transplantation2013，3，4： | 3 |
| 2 | Lymphangiogenesis and tumor metastasis显示文摘 | Tille JC Nisato R | 2003 | Cell Tissue Res2003，314，1： | 1 |
| 3 | Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3显示文摘 | Apte BA Pepper MS Voest E Montesano R Olsen B Murphy G | 1997 | Invest Ophthalmol Vis Sci1997，38，： | 1 |
| 4 | Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrohagecolony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immume responses 显示文摘 | Stripecke R Cardoso AA Pepper KA | 2000 | Blood2000，96，4： | 1 |
| 5 | Attitudes to Climate Change and the Actions for Energy Decay of Regular Church-going Christians:The Effects of Religious Persuasions and Social Capital显示文摘 | Leonard R J Pepper M D | 2015 | Social Compass2015，62，3： | 1 |
| 6 | The relative abilities of two breed of chicken and two varieties of turkeys to metabolize dietary energy nitrogen显示文摘 | SLINGAR S J SIBBALD I R PEPPER W F | 1964 | Poultry Science1964，43，： | 1 |
| 7 | Electrophysiological identification of site insensitive mechanisms in knock down resistant strains (kdr, super kdr) of the house fly larva (Musca dora estica)显示文摘 | Pepper D R Micheal P O | 1993 | Pestic Sci1993，39，： | 1 |
| 8 | Lymphangiogenesis and tumor metastasis 显示文摘 | Pepper MS Tille JC Nisato R | 2003 | Cell Tissue Res2003，314，1： | 1 |
| 9 | Off-pump myocardial revascularization is associated with less incidence of stroke in elderly patients显示文摘 | Thanos Athanasiou Sharif Al-Ruzzeh Pankaj Kumar Mary-Clare Crossman Mohamed Amrani John R Pepper Rex Del Stanbridge Roberto Casula Brian Glenville | 2004 | The Annals of Thoracic Surgery2004，，2： | 1 |
| 10 | Intravenous cyclophosphamide and plasmapheresis in dialysis- dependent ANCA -associated vasculitis显示文摘 | Pepper R J Chanouzas D Tarzi R | 2013 | Clin J Am Soc Nephrol2013，8，2： | 1 |
| 11 | Leaf orientation and yield of maize显示文摘 | Pepper G Z Pearce R B Mock J J | 1977 | Crop Science1977，17，6： | 1 |
| 12 | Long-term changes in productivity of eucalypt plantations under different harvest residue and nitrogen management显示文摘 | Corbeel M McMurtrie R E Pepper D A | 2005 | Forest Ecology and Management2005，217，： | 1 |
| 13 | Rituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids显示文摘 | PEPPER R GRIFFITH M KIRWAN C | 2009 | Nephrol Dial Transplant2009，24，12： | 1 |
| 14 | Alteration of serum pituitary hormone levels in postmenopausal women with stroke显示文摘 | Pepper GM Koenigsberg R Zito JL | 1993 | Stroke1993，24，6： | 1 |
| 15 | Nutrient Losses by Surface Runoff Following the Application of Organic Manures to Arable Land Nitrogen显示文摘 | Smith K A Jackson D R Pepper T J | 2001 | Environment Pollution2001，112，： | 1 |
| 16 | The cardiac endothelium: cardioactive mediators显示文摘 | Shah A M Grocott M R M Pepper C B | 1996 | Prog Cardiovasc Dis1996，39，3： | 1 |
| 17 | Lentiviral vectors for efficient delivery of CD80 and granulocyte - macrophage - colony - stimulating factor in human acute lymphoblastie leukemia and acute myeloid leukemia cells to induce antileukemic immune responses 显示文摘 | STRIPECKE R CARDOSO A A PEPPER K A | 2000 | Blood2000，96，4： | 1 |
| 18 | Leaf orientation and yield of maize显示文摘 | Pepper G E Pearce R B Mock J J | 1977 | Crop Science1977，，17： | 1 |
| 19 | Luxury water use by bermudagrass turf显示文摘 | Kneebone W R Pepper I L | 1984 | Agronomy Journal1984，76，： | 1 |
| 20 | Sporicidal activity of alkaline alcoholic saturated dialdehyde solutions显示文摘 | Pepper R E Chandler V L | 1963 | Appl Microbiol1963，11，： | 1 |
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