|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methods, units and quality requirements for the analysis of haemoglobin A_(1c) in diabetes mellitus显示文摘The formation of glycohemoglobin, especially the hemoglobin A1c(Hb_(A1c)) fraction, occurs when glucose becomes coupled with the amino acid valine in the β-chain of Hb; this reaction is dependent on the plasma concentration of glucose. Since the early 1970 s it has been known that diabetics display higher values of Hb_(A1c) because they have elevated blood glucose concentrations. Thus Hb_(A1c) has acquired a very important role in the treatment and diagnosis of diabetes mellitus. After the introduction of the first quantitative measurement of Hb_(A1c), numerous methods for glycohemoglobin have been introduced with different assay principles: From a simple minicolumn technique to the very accurate automated highpressure chromatography and lastly to many automated immunochemical or enzymatic assays. In early days, the results of the quality control reports for Hb_(A1c) varied extensively between laboratories, therefore in United States and Canada working groups(WG) of the Diabetes Controls and Complications Trial(DCCT) were set up to standardize the Hb_(A1c) assays against the DCCT/National Glycohemoglobin Standardization Program reference method based on liquid chromatography. In the 1990 s, the International Federation of Clinical Chemistry and Laboratory Medicine(IFCC) appointed a new WG to plan a reference preparation and method for the Hb_(A1c) measurement. When the reference procedureswere established, in 2004 IFCC recommended that all manufacturers for equipment used in Hb_(A1c) assays should calibrate their methods to their proposals. This led to an improvement in the coefficient of variation(CV%) associated with the assay. In this review, we describe the glycation of Hb, methods, standardization of the Hb_(A1c) assays, analytical problems, problems with the units in which Hb_(A1c) values are expressed, reference values, quality control aspects, target requirements for Hb_(A1c), and the relationship of the plasma glucose values to Hb_(A1c) concentrations. We also note that the acceptance of the mmol/mol system for Hb_(A1c) as recommended by IFCC, i.e., the new unit and reference ranges, are becoming only slowly accepted outside of Europe where it seems that expressing Hb_(A1c) values either only in per cent units or with parallel reporting of percent and mmol/mol will continue. We believe that these issues should be resolved in the future and that it would avoid confusion if mmol/mol unit for Hb_(A1c) were to gain worldwide acceptance. | Ilkka Penttil? Karri Penttil? P?ivi Holm Harri Laitinen P?ivi Ranta Jukka T?rr?nen Rainer Rauramaa | 2016 | World Journal of Methodology2016，6，2： | 3 |
| 2 | Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis 显示文摘 | Penttil M J skel inen E Hirvonen N | 2014 | The British Journal of Psychiatry2014，205，2： | 1 |
| 3 | Cardiovascular and parasym pathetic effect s of dexmedetomidine in healthy subjects显示文摘 | PENTTIL J H ELMINEN A ANTTILA M | | 0，，05： | 1 |
| 4 | Pitfalls in the diagnosis of drug smuggler′s abdomen显示文摘 | Karhunen PJ Suoranta H Penttil A | 1991 | J Forensic Sci1991，36，2： | 1 |
| 5 | Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery显示文摘 | Laine P Kaartinen M Penttil A | 1999 | Circulation1999，99，3： | 1 |
| 6 | Evolution, risk factors, and prognostic implications of albuminuria in NIDDM 显示文摘 | Niskanen L K Penttil I Parviainen M | 1996 | Diabetes Care1996，19，5： | 1 |
| 7 | Spectral attenuation of solar ultraviolet radiation in humic lakes in Central Finland显示文摘 | Huovinen P S Penttil H Soimasuo M R | 2003 | Chemosphere2003，51，3： | 1 |
| 8 | Cardiovascular and para- sympathetic effects of dexmetomidine in healthy subjects显示文摘 | Penttil J Helminen A Anttila M | 2007 | Cana- dian J physiol pharmacol2007，82，5： | 1 |
| 9 | Single-Electron Transistor Made of Multiwalled Carbon Nanotube Using Scanning Probe Manipulation显示文摘 | Leif Roschier Jari Penttil Michel Martin Pertti Hakonen and Mikko Paalanen | 1999 | Appled Physics Letters1999，75，52： | 1 |
| 10 | Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects显示文摘 | Penttil J Helminen A Anttila M | 2004 | Can J Physiol Pharmacol2004，82，5： | 1 |
| 11 | Chlamydia pneunoniae infection in IL-10 knock out mice:accelerated clearance but severe pulmonary inflammatory response显示文摘 | Penttil(a)1 T Haveri A Tammiruusu A | | 0，，01： | 1 |
| 12 | Transcriptional regulation of plant cell wall degradation by filamentous fungi显示文摘 | Aro N Pakula T Penttil?M | | 0，，04： | 1 |
| 13 | Cardiovascular and parasympathetic effect of dexmetomidine in healthy subjects显示文摘 | Penttilal J Helminen A Anttila M | 2004 | Cana J phys and pharm2004，82，4： | 1 |
| 14 | Production of Chlamydia pneumoniae Proteins in Bacillus subtilis and Their Use in Characterizing Immune Responses in the Experimental Infection Model显示文摘 | Airaksinen U Penttil T Wahlstr m E | 2003 | Clinical and Diagnostic Laboratory Immunology2003，10，3： | 1 |
| 15 | Laccase from the white-rot fungus Trametes versicolor: cDNA cloning of lccl and expression in Pichia pastoris 显示文摘 | Jonsson L J Saloheimo M Penttil M | 1997 | Current Genetics1997，32，6： | 1 |
| 16 | EG Ⅲ,a new endoglucanase from Trichoderma reesei:the characterization of both gene and enzyme显示文摘 | Saloheimo M Lehtovaar P Penttil(a) M | | 0，，01： | 1 |
| 17 | 5-Hydroxytryptamine in the enterochromaffin cells of the guinea pig alimentary tract显示文摘 | Penttil A | 1976 | Histochemie1976，11，2： | 1 |
| 18 | Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects 显示文摘 | Penttil J Helminen A Anttila M | 2004 | Can J physiol pharmacol2004，82，5： | 1 |
| 19 | Effects of inactivation and constitutive expression of the untblded-protein response pathway on protein production in the yeast Saccharomyces cerevisi~u~显示文摘 | Valkonen M Penttil~i M Saloheimo M | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 20 | Decomposition of Scots pine fine woody debris in boreal conditions: Implications for estimating carbon pools and fluxes显示文摘 | V~ivi ovh P Penttil~i T Laiho R | 2009 | Forest Ecology and Management2009，257，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员