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| 1 | A single-cell transcriptomic atlas of primate pancreatic islet aging显示文摘Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the efforts to unravel the molecular drivers underlying endocrine aging.To overcome these obstacles,we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys.Despite sex differences and increased transcriptional variations,agedβ-cells showed increased unfolded protein response(UPR)along with the accumulation of protein aggregates.We observed transcriptomic dysregulation of UPR components linked to canonical ATF6 and IRE1 signaling pathways,comprising adaptive UPR during pancreatic aging.Notably,we found aging-relatedβ-cell-specific upregulation of HSP90 B1,an endoplasmic reticulum-located chaperone,impeded high glucose-induced insulin secretion.Our work decodes aging-associated transcriptomic changes that underlie pancreatic islet functional decay at single-cell resolution and indicates that targeting UPR components may prevent loss of proteostasis,suggesting an avenue to delayingβ-cell aging and preventing aging-related diabetes. | Jingyi Li Yuxuan Zheng Pengze Yan Moshi Song Si Wang Liang Sun Zunpeng Liu Shuai Ma Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Weiqi Zhang Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | National Science Review2021，8，2： | 3 |
| 2 | An enrichment model using regular health examination data for early detection of colorectal cancer显示文摘Objective: Challenges remain in current practices of colorectal cancer(CRC) screening, such as low compliance,low specificities and expensive cost. This study aimed to identify high-risk groups for CRC from the general population using regular health examination data.Methods: The study population consist of more than 7,000 CRC cases and more than 140,000 controls. Using regular health examination data, a model detecting CRC cases was derived by the classification and regression trees(CART) algorithm. Receiver operating characteristic(ROC) curve was applied to evaluate the performance of models. The robustness and generalization of the CART model were validated by independent datasets. In addition, the effectiveness of CART-based screening was compared with stool-based screening.Results: After data quality control, 4,647 CRC cases and 133,898 controls free of colorectal neoplasms were used for downstream analysis. The final CART model based on four biomarkers(age, albumin, hematocrit and percent lymphocytes) was constructed. In the test set, the area under ROC curve(AUC) of the CART model was 0.88 [95%confidence interval(95% CI), 0.87-0.90] for detecting CRC. At the cutoff yielding 99.0% specificity, this model’s sensitivity was 62.2%(95% CI, 58.1%-66.2%), thereby achieving a 63-fold enrichment of CRC cases. We validated the robustness of the method across subsets of test set with diverse CRC incidences, aging rates, genders ratio, distributions of tumor stages and locations, and data sources. Importantly, CART-based screening had the higher positive predictive value(1.6%) than fecal immunochemical test(0.3%).Conclusions: As an alternative approach for the early detection of CRC, this study provides a low-cost method using regular health examination data to identify high-risk individuals for CRC for further examinations. The approach can promote early detection of CRC especially in developing countries such as China, where annual health examination is popular but regular CRC-specific screening is rare. | Qiang Shi Zhaoya Gao Pengze Wu Fanxiu Heng Fuming Lei Yanzhao Wang Qingkun Gao Qingmin Zeng Pengfei Niu Cheng Li Jin Gu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 3 | Gas-phase dehydrochlorination of 1, 1, 2, 2-tetrachloroethane over the non-metal supported ionic liquid catalyst显示文摘Developing of non-metallic catalyst to replace metal catalyst is a meaningful and challenging direction.In this work,the non-metallic catalyst was synthetized successfully by loading ionic liquid onto the silica surface,which was applied for the gas-phase dehydrochlorination of 1,1,2,2-tetrachloroethane.The 12%TPPC/SiO2(wt%)showed the best results with the conversion of 1,1,2,2-tetrachloroethane reaching 100%.The selectivity of 1,1,2-trichloroethylene was 100%,and no deactivation was found during the evaluation period.The catalytic mechanism was investigated and possible reaction route was given,which was a reference for fabricating and design of solid base catalyst. | Pengze Zhang Yangzhen Jin Zhaobin Jiang Guanqun Xie Qunfeng Zhang Xiaonian Li | 2020 | Chinese Journal of Chemical Engineering2020，28，6： | 2 |
| 4 | An improved Hilbert Huang transform and its application in vibration signal analysis显示文摘 | PengZ K Tse P W Chu F L | 2005 | Journal of Sound and Vibration2005，286，12： | 1 |
| 5 | 显示文摘 | Yang H ZhuP PengZ etal | 2001 | EurPolymJ2001，37，： | 1 |
| 6 | Targeting BCR tyrosinel77 site withnovel SH2-DED causes selective leukemia cell death in vitro and invivo显示文摘 | PengZ Yuan Y Li YJ | 2012 | Int J Biochem Cell Biol2012，44，6： | 1 |
| 7 | UltrafineWC' Nice-mentedcarbidesfabricatedbysparkplasmasintering显示文摘 | RongH PengZ RenX etal | 2012 | Materials Science and Engineering:A2012，，532： | 1 |
| 8 | Areview ofcementedcar-bidesforrockdrilling:anoldbutstilltoughchallengeingeo-engineering显示文摘 | RenX Miao H PengZ | 2013 | InternationalJournalofRefrac-tory MetalsandHard Materials2013，，39： | 1 |
| 9 | Tea polyphe- nols protect against irradiation-induced injury in sub- mandibular glands~ cells: a preliminary study显示文摘 | PENGZ XUZW WENWS etal | 2011 | Arch Oral Biol2011，56，： | 1 |
| 10 | CpG oligodeoxynucleotide vaccination suppresses IgE induction but may fail to down-regulate ongoing IgE responses in mice显示文摘 | PENGZ K WANG H S MAOX Y | 2001 | Int Immunol2001，13，1： | 1 |
| 11 | The decline of winter monsoon velocity in the South China Sea through the 20th century : Evidence from the St/Ca records in corals显示文摘 | LIU Y PENGZ CHEN T WEI GJ SUN WD SUN RY HE JF LIU GJ CMOU CL ZARTMAN RE | 2008 | Global and Planetary Change2008，63，1： | 1 |
| 12 | SnO2nanocrystals on self-organized TiO2 nanotube array as three-dimensional electrode for lithium ion microbatteries显示文摘 | GuoDD ZaiPG PengZ | 2010 | Mater Chem2010，20，11： | 1 |
| 13 | PreparationanditselectroGchemicalperformanceofnickeloxidedopedwithcopperoxide 显示文摘 | XuH PengZ LuY etal | 2012 | JournalofFunctional Materials2012，43，14： | 1 |
| 14 | Expression of COX-2, MMP- 2 and VEGF in stage II and III colorectal cancer and the clinical significance 显示文摘 | PENGZ H WAN D S LI L R | 2011 | Hepatogastroenterology2011，58，106： | 1 |
| 15 | InvestigationofpolyanilinefilmsdopedwithNi2+ astheelectrodematerialforelecGtrochemicalsupercapacitors 显示文摘 | Xu H LiJ PengZ etal | 2013 | Electrochimica Acta2013，90，： | 1 |
| 16 | Protein quality control of cell stemness显示文摘Protein quality control(PQC)systems play essential roles in the recognition,refolding and clearance of aberrant proteins,thus ensuring cellular protein homeostasis,or proteostasis.Especially,continued proliferation and differentiation of stem cells require a high rate of translation;therefore,accurate PQC systems are essential to maintain stem cell function.Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells.This review focuses on current knowledge regarding the components of the proteostasis network in stem cells,and the importance of proteostasis in maintaining stem cell identity and regenerative functions.A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases. | Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu | 2020 | Cell Regeneration2020，9，1： | 1 |
| 17 | Adsorption of (-)-Epi- gallocatechin-3-gallate (EGCG) onto oa' 15-Glucan 显示文摘 | Gao R P Liu H PengZ | 2012 | Food Chemistry2012，132，4： | 1 |
| 18 | AccelerAtion of Modem acidification in the South China Sea driven by anthropogenic CO2显示文摘 | LIUY PENGZ ZHOUR SONGS LIUW YOUCF LINYP YU K WU C C WEI G J XIE L H BURR G S SHEN C C | 2014 | Scientific Reports2014，4，： | 1 |
| 19 | PreparationandperGformancesofanovelintelligenthumiditycontrolcomGpositematerial显示文摘 | YangH PengZ ZhouY etal | 2011 | EnergyandBuildings2011，43，23： | 1 |
| 20 | The jobs-housing balance and urban commuting显示文摘 | PengZ R | 1997 | Ur-ban Studies1997，34，8： | 1 |
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