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| 1 | Discovery and preliminary study of the high tungsten and lithium contents in the Dazhuyuan bauxite deposit, Guizhou, China显示文摘Bauxite in China remains an urgently needed resource largely dependent on imports. Based on the study of the newly-discovered Dazhuyuan bauxite deposit in northeastern Guizhou, we have found new enrichment of tungsten and lithium in bauxite, with the highest WO 3 content up to 0.33% and the highest Li 2 O content up to 0.58%. The present paper reports the initial result, and the spatial distribution feature of W and Li in the ore body (with Li enriched mostly in the north part of the west limb of the Liyuan syncline, whereas W enriched mostly in the central part of the east limb). The results suggest that it is necessary to delineate lithium and tungsten ore body independently, discuss the feasibility of its industrial utilization, and point out the new direction of synthetic appraisal for such kinds of traditional mineral resources, in order to forecast and assess bauxite resources in the region. | WANG DengHong LI PeiGang QU WenJun YIN LiJuan ZHAO Zhi LEI ZhiYuan WEN ShenFu | 2013 | Science China Earth Sciences2013，56，1： | 16 |
| 2 | Preparation and anisotropic properties of textured structural ceramics: A review显示文摘Ceramics are usually composed of randomly oriented grains and intergranular phases, so their properties are the statistical average along each direction and show isotropy corresponding to the uniform microstructures. Some methods have been developed to achieve directional grain arrangement and preferred orientation growth during ceramic preparation, and then textured ceramics with anisotropic properties are obtained. Texture microstructures give particular properties to ceramics along specific directions, which can effectively expand their application fields. In this review, typical texturing techniques suitable for ceramic materials, such as hot working, magnetic alignment, and templated grain growth(TGG), are discussed. Several typical textured structural ceramics including α-Al2O3 and related nacre bioinspired ceramics, Si3N4 and SiAlON, h-BN, MB2 matrix ultra-high temperature ceramics, MAX phases and their anisotropic properties are presented. | Zhuo ZHANG Xiaoming DUAN Baofu QIU Zhihua YANG Delong CAI Peigang HE Dechang JIA Yu ZHOU | 2019 | Journal of Advanced Ceramics2019，8，3： | 14 |
| 3 | Putative hAPN receptor binding sites in SARS_CoV spike protein显示文摘AIM:To obtain the information of ligand-receptor binding between thd S protein of SARS_CoV and CD13, identify the possible interacting domains or motifs related to binding sites, and provide clues for studying the functions of SARS proteins and designing anti-SARS drugs and vaccines. METHODS: On the basis of comparative genomics, the homology search, phylogenetic analyses, and multi-sequence alignment were used to predict CD13 related interacting domains and binding sites sites in the S protein of SARS_CoV. Molecular modeling and docking simulation methods were employed to address the interaction feature between CD13 and S protein of SARS_CoV in validating the bioinformatics predictions. RESULTS:Possible binding sites in the SARS_CoV S protein to CD13 have been mapped out by using bioinformatics analysis tools. The binding for one protein-protein interaction pair (D757-R761 motif of the SARS_CoV S protein to P585-A653 domain of CD13) has been simulated by molecular modeling and docking simulation methods. CONCLUSION:CD13 may be a possible receptor of the SARS_CoV S protein which may be associated with the SARS infection. This study also provides a possible strategy for mapping the possible binding receptors of the proteins in a genome. | YUXiao-Jing LUOCheng LinJian-Cheng HAOPei HEYou-Yu GUOZong-Ming QINLei SUJiong LIUBo-Shu HUANGYin NANPeng LIChuan-Song XIONGBin LUOXiao-Min ZHAOGuo-Ping PEIGang CHENKai-Xian SHENXu SHENJian-Hua ZOUJian-Ping HEWei-Zhong SHITie-Liu ZHONGYang JIANGHua-Liang LIYi-Xue | 2003 | Acta Pharmacologica Sinica2003，24，6： | 13 |
| 4 | Sequence Thickness and its Response to Episodic Tectonic Evolution in Paleogene Qikou Sag, Bohaiwan Basin显示文摘The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence thickness, as well as the study of consedimental tectonic activity, subsidence history, paleogeomorphology and the coupling relationship among them. The faults controlling action was the dominant mechanism during rifting stage I , as the depression was the dominant mechanism during rifting stage III, which embodies a process from intense disparity fault depression to integral subsidence. Meanwhile, under the control of regional faulting and later stage depression, subsidence rate centers and paleogeomorphic concave centers are always corresponding to the sequence thickness centers, and the changes of subsidence centers and paleogeomorphology concave centers are consistent with the migration of thickness centers, which presents the restriction, coupling and response among them and clarifies the law that tectonic activity controls the basin fill by means of controlling the subsidence rate and paleogeomorphology from contributing factor angle. On this basis, the dynamic evolution of the composite pattern of structure-subsidence-deposition in the fault controlling actic region during the three rifting stages and their petroleum geological significance has been discussed. | CHEN Si WANG Hua ZHOU Lihong HUANG Chuanyan WANG Jiahao REN Peigang XIANG Xuemei | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 11 |
| 5 | Zika virus and Zika fever显示文摘An emerging mosquito-borne arbovirus named Zika virus(ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 countries, accumulating evidences have demonstrated a close association between infant microcephaly and Zika infection in pregnant women. Here, we reviewed the virological, epidemiological, and clinical essentials of ZIKV infection. | Zhaoyang Wang Peigang Wang Jing An | 2016 | Virologica Sinica2016，31，2： | 5 |
| 6 | Au plasmon enhanced high performance β-Ga_2O_3 solar-blind photo-detector显示文摘Surface plasmon polariton(SPP) is electro-magnetic wave coupled to free electron oscillations near the surface of metal, and has been used to improve the photoelectric properties in many optoelectronic devices. In the present study, the Au nanoparticles(NPs)/β-Ga_2O_3 composite thin film was fabricated through depositing Au ultra-thin film on the β-Ga_2O_3 thin film followed by post-thermal treatment. Compared to bare β-Ga_2O_3 thin film, a significant absorption around 510 nm, which is attributed to SPP of Au NPs, was observed in the UV–vis spectrum of Au NPs/β-Ga_2O_3 composite thin film. The results showed that the photoresponse of Au NPs/Ga_2O_3 photodetector illuminated under 254 nm +532 nm light was much higher than that illuminated under 254 nm light, indicating an enhancement of photoelectric property for the solar-blind photodetector based on β-Ga_2O_3 thin film. | Yuehua An Xulong Chu Yuanqi Huang Yusong Zhi Daoyou Guo Peigang Li Zhenping Wu Weihua Tang | 2016 | Progress in Natural Science:Materials International2016，26，1： | 5 |
| 7 | Retrofit design of composite cooling structure of a turbine blade by fluid networks and conjugate heat transfer methods显示文摘This article discusses the development of the numerical methods of gas flow coupled with heat transfer,and introduces the fluid net-works method for rapid prediction of the performance of the composite cooling structures in turbine blade.The reliability of these methods is verified by comparing experimental data.For a HPT rotor blade,a rapid prediction on the internal cooling structures is first made by using the fluid network analysis,then an assessment of aerodynamic and heat transfer characteristics is conducted.Based on the network analysis results,three ways to improve the design of the cooling structures are tested,i.e.,adjusting the cooling gas flow mass ratios for different inner cooling cavities,reducing the flow resistances of the channel turning structures,and improving the local internal cooling structure geometries with high temperature distribution.Through the verification of full three-dimensional gas/solid/coolant conjugate heat transfer calculation,we conclude that the modified design can make the overall temperature distribution more even by significantly reducing the highest temperature of the blade surface,and reasonably matching the parameters of different coolant inlets.The results show that the proposed calculation methods can remarkably reduce the design cycle of complex turbine blade cooling structure. | YAN PeiGang SHI Liang WANG XiangFeng HAN WanJin | 2013 | Science China(Technological Sciences)2013，56，12： | 5 |
| 8 | Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis显示文摘Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis,intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8?T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8?T cells are involved in the pathogenesis of RE. | Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan | 2018 | Virologica Sinica2018，33，5： | 4 |
| 9 | Review of micro/nano technologies and theories for electroporation of biological cells显示文摘Electroporation (EP) is one of the important techniques for the introduction of genes and drugs into cells with intense pulsed electric field to induce nanometer-sized electropores on cell membranes.Recently,micro/nano technology has been applied to many novel micro EP devices which can not only significantly increase uptake of biomolecules,DNA transfection and cell viability,but also enable large-scale single-cell EP.However,most EP theories developed in the past three decades can not precisely predict the experimental results of EP of biological cells.With the advanced micro EP chips for large-scale single-cell EP experiments,more precise EP theoretical models can be developed to describe the complicated multiscale dynamic behavior of EP. | LEE YiKuen DENG PeiGang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 4 |
| 10 | BEM/FDM Conjugate Heat Transfer Analysis of a Two-dimensional Air-cooled Turbine Blade Boundary Layer显示文摘A coupled 边界元素方法(BEM ) 和有限差别方法(频分多路复用) 被使用解决结合热转移问题一二维空气冷却汽轮机片界面层。泛泛地联合的策略被采用,在哪个地方程的每个集合被解决为其它提供边界条件。海军司烧方程被 HIT-NS 代码解决。在这代码, FDM 被收养并且被用来在液体区域解决对流的热转移。BEM 代码被用来在稳固的区域解决传导热转移。一个重申的集中标准在液体固体接口是温度和热流动的连续性。从在这篇论文采用的 BEM 的数字结果在对分析答案的结果和商业代码的结果的好同意,例如流畅 6.2。BEM 避免在另外的计算方法需要的复杂网孔并且节省计算时间。结果证明在这篇论文采用的 BEM 能与更少的边界点在数字结果给一样的精确。比较 conjugate 与一个绝热壁流动答案的数字结果结果,它在金属温度的分发揭示重要差别。结果从结合热转移分析是更精确的,他们接近汽轮机的现实主义的热环境。 | Wang Zhenfeng Yan Peigang Guo Zhaoyuan Han Wanjin | 2008 | Journal of Thermal Science2008，17，3： | 4 |
| 11 | Elevated expression of EBV and TLRs in the brain is associated with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare pediatric neurological disorder, the etiology of which remains unclear. It has been speculated that the immunopathogenesis of RE involves damage to neurons, which eventually leads to the occurrence of RE. Viral infection may be a critical factor in triggering RE immunopathogenesis. In this study, we analyzed the expression of Epstein-Barr virus(EBV) antigens as well as of Toll-like receptor 3(TLR3), TLR9, and downstream adapter TIRdomain-containing adapter-inducing interferon-β(TRIF) in the brain tissues of 26 patients with RE and 16 control individuals using immunohistochemistry(IHC). In the RE group, EBV antigens were detected in 53% of individuals at various expression levels. In contrast, there was no detectable EBV antigen expression in control brain tissues. Moreover, we found marked increases in the expression of TLR3, TLR9, and TRIF in the brain tissues of RE patients compared with levels in the control group. Furthermore, among RE cases, EBV expression and high TLR3 expression were associated with more severe brain atrophy. Our results suggest that the elevated expression of EBV and TLRs may be involved in RE occurrence through the activation of downstream molecules. | Xin Wang Yisong Wang Dong Liu Peigang Wang Dongying Fan Yuguang Guan Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，5： | 3 |
| 12 | Effects of Hot Steam Injection from the Slot at the Trailing Edge on Turbine Nozzle Vane Flow Field显示文摘Moisture removal slot configurations with three different opening widths are in turn set at the trailing edges of a turbine hollow guide vane.The flow fields are analyzed by two-phase flow numerical simulation of solving the steady three dimensional Reynolds averaged Navier-Stokes equations on the basis of the real water vapor thermo-physical properties,and the blade temperature field is solved by the fluid-solid coupling.Exergy parame- ter is introduced as a measure to evaluate the economic cost of energy conversion process.The results indicate that the bigger slot allow lower quality of hot steam in the case of the equivalent injected quantity,while it has a higher exergy effective efficiency of the mixing process in the cascade channels.The hot steam injecting at the trailing edges has an optimal injected mass flow rate for a relatively large slot,on this point the exergy effective efficiency is the maximum,namely the flow loss is the minimum. | Liang Xu Peigang Yan Hongyan Huang Wanjin Han | 2008 | Journal of Thermal Science2008，17，4： | 3 |
| 13 | Unsteady Numerical Simulation of Steam-Solid Two-Phase Flow in the Governing Stage of a Steam Turbine显示文摘Solid particle erosion (SPE) in an ultra-supercritical steam turbine control stage with block configuration is investigatednumerically, based on the finite volume method and the fluid-particle coupling solver. We apply the particlediscrete phase model to model the solid particles flow, and use the Euler conservation equations to solve thecontinuous phase. The investigation is focused on the influence of the solid particle parameters (such as particlediameter, particle velocity and particle trajectory) on the erosion rate of the stator and rotor blade surface in unsteadycondition. The distributions of the highly eroded zone on the stator and rotor blade surfaces are shown anddiscussed in detail according to the mechanism of solid particle/blade wall interaction. We obtain that the erosionrate of the vane blade is sensitive to the fluctuation of the potential flow field, and the smaller particle has agreater impact on the erosion distribution of rotor blade. The erosion rate does not entirely depend on the diametersize of the solid particle. | Yufeng Li Peigang Yan Wanjin Han | 2009 | Journal of Thermal Science2009，18，4： | 2 |
| 14 | Protective effects and potential underlying mechanisms of sodium copper chlorophyllin against ethanol-induced gastric ulcer in mice显示文摘In study,we aimed to determine the mechanisms underlying the gastroprotective effects of sodium copper chlorophyllin(SCC)against ethanol-induced gastric ulcer injury in mice.First,the gastroprotective effects of SCC against gastric ulcer induced by ethanol were assessed.Then,biochemical,histopathological,immunohistochemistry assays,and western blot analysis were conducted to determine the possible mechanisms of action underlying the effects of SCC.Compared to the effects of omeprazole(OME)in a confirmed mouse model of ethanol-induced gastric ulcer injury,treatment with various doses of SCC resulted in up-regulation of Bcl-2 and down-regulation of the pro-apoptotic protein Bax.Significant decreases in the levels of the malondialdehyde(MDA),myeloperoxidase(MPO),and NO in the gastric tissues were observed.Furthermore,inflammatory cytokine analysis revealed that SCC treatment inhibited the expressions of TNF-αand IL-6,greatly reduced the phosphorylation level of IκB,and repressed the nuclear translocation of NF-κB p65,which demonstrated that SCC inhibited the activation of the NF-κB pathway.The present findings suggest that the protective effects of SCC may be beneficial as a potential preventive and therapeutic agent for gastric ulcer through the NF-κB pathway.Taken together,SCC administration significantly decreased the levels of MPO,NO,and MDA in gastric tissue and exerted a powerful anti-inflammatory activity as demonstrated by reduction in the secretions of proinflammatory mediators such as IL-6 and TNF-α in the serum of mice exposed to ethanol. | Huawei Lv Yan Lin Peigang Liu Weiqing Liang Kemin Wei Jinbao Pu Hongjian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 2 |
| 15 | Decreases in Both the Seroprevalence of Serum Antibodies and Seroprotection against Japanese Encephalitis Virus among Vaccinated Children显示文摘The incidence of Japanese encephalitis(JE)has significantly decreased in China due to JE vaccines.In this study,we investigated the post-JE vaccination seroprevalence and protection provided by vaccinated sera against Japanese encephalitis virus(JEV)to elucidate the persistence and waning of antibodies to JEV among JE-SA14-14-2-vaccinated children.A total of 300 serum samples were collected from vaccinated children aged 3-10 years in Zhaotong,Yunnan,China.The seroprevalence of anti-JEV antibodies was determined by enzyme-linked immune sorbent assay and plaque reduction neutralization test.The highest seropositivity of 82%was observed in vaccinated children during the first 0.5-1.5 years after booster vaccination.Then,the seropositivity began to decline and remained lower than the original level observed in the 0.5-1.5-year group.An association was found between the waning of seroprevalence and elapsed time of the post-booster vaccination.Similarly,the neutralizing antibody(nAb)titres gradually decreased over time,and the levels showed a positive correlation with the protective efficacy in mice.This finding suggests that nAbs play an important role in the antiviral process and that the nAb titre is an adequately credible parameter for evaluating the protective efficacy induced by the JE vaccine.Our results provide data that clarify the persistence and waning of antibodies to JEV,which may help elucidate the pathogenesis of JE. | Ran Wang Lyu Xie Na Gao Dongying Fan Hui Chen Peigang Wang Hongning Zhou Jing An | 2019 | Virologica Sinica2019，34，3： | 2 |
| 16 | Study on wellbore temperature of riserless mud recovery system by CFD approach and numerical calculation显示文摘The riserless mud recovery(RMR)system abandons the riser used in conventional offshore drilling,and the drill string above the seabed is directly exposed to seawater,resulting in convective heat transfer from the drilling fluid in the drill string to seawater.Therefore,the wellbore temperature distribution in the RMR system is quite different from the conventional offshore drilling.In this paper,based on the heat transfer characteristics of the RMR system,a mathematical model of the thermal field of the RMR system is established.The data used in this paper come from a vertical well in the South China Sea.Computational Fluid Dynamics(CFD)software is used to simulate the temperature distribution in drill string at different seawater depths and different formation depths in this paper,and the simulation results are compared with the calculation results of the mathematical model,so as to verify the feasibility of the mathematical model established in this paper.Combined with the calculation results of the mathematical model,this paper also explores the effect of different discharge capacity and different injection temperature of drilling fluid on the wellbore temperature change. | Xin Li Jie Zhang Xu Tang Gezhen Mao Peigang Wang | 2020 | Petroleum2020，6，2： | 2 |
| 17 | Microstructural evolution of h-BN matrix composite ceramics with La-Al-Si-O glass phase during hot-pressed sintering显示文摘BN/La-Al-Si-O composite ceramics were fabricated by hot-pressed sintering using hexagonal boron nitride(h-BN),lanthanum oxide(La_(2)O_(3)),aluminia(Al_(2)O_(3)),and amorphous silica(SiO_(2))as the raw materials.The effects of sintering temperature on microstructural evolution,bulk density,apparent porosity,and mechanical properties of the h-BN composite ceramics were investigated.The results indicated that La-Al-Si-O liquid phase was formed during sintering process,which provided an environment for the growth of h-BN grains.With increasing sintering temperature,the cristobalite phase precipitation and h-BN grain growth occurred at the same time,which had a significant influence on the densification and mechanical properties of h-BN composite ceramics.The best mechanical properties of BN/La-Al-Si-O composite ceramics were obtained under the sintering temperature of 1700℃.The elastic modulus,flexural strength,and fracture toughness were 80.5 GPa,266.4 MPa,and 3.25 MPa·m^(1/2),respectively. | Baofu QIU Xiaoming DUAN Zhuo ZHANG Chen ZHAO Bo NIU Peigang HE Delong CAI Lei CHEN Zhihua YANG Yujin WANG Dechang JIA Yu ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 2 |
| 18 | Electroporation-Mediated Immunization of a Candidate DNA Vaccine Expressing Dengue Virus Serotype 4 prM-E Antigen Confers Long-Term Protection in Mice显示文摘Dengue fever, caused by dengue viruses(DENVs), is a widespread mosquito-borne zoonotic disease; however, there is no available anti-dengue vaccine for worldwide use. In the current study, a DNA vaccine candidate(pV-D4 ME) expressing prM-E protein of DENV serotype 4(DENV-4) was constructed, and its immunogenicity and protection were evaluated in immunocompetent BALB/c mice. The pV-D4 ME candidate vaccine induced effective humoral and cellular immunity of mice against DENV-4 in vivo when administered both at 50 μg and 5 μg through electroporation. Two weeks after receiving three immunizations, both doses of pV-D4 ME DNA were shown to confer effective protection against lethal DENV-4 challenge. Notably, at 6 months after the three immunizations, 50 μg, but not 5 μg, of pV-D4 ME could provide stable protection(100% survival rate) against DENV-4 lethal challenge without any obvious clinical signs. These results suggest that immunization with 50 μg pV-D4 ME through electroporation could confer effective and long-term protection against DENV-4, offering a promising approach for development of a novel DNA vaccine against DENVs. | Ziyang Sheng Hui Chen Kaihao Feng Na Gao Ran Wang Peigang Wang Dongying Fan Jing An | 2019 | Virologica Sinica2019，34，1： | 2 |
| 19 | Microfiber Bragg Grating for Temperature and Strain Sensing Applications显示文摘 | Jie TIAN Shuhui LIU Wenbing YU Peigang DENG | 2017 | Photonic Sensors2017，7，1： | 1 |
| 20 | Two-dimensional micro-bubble actuator array to enhance the efficiency of mo- lecular beacon based DNA micro-biosensors 显示文摘 | Deng Peigang Lee Yikuen Cheng Ping | 2006 | Biosensors and Bioelectronics2006，21，8： | 1 |
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