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| 1 | Differences between main-duct and branch-duct intraductal papillary mucinous neoplasms of the pancreas显示文摘In the last decade,intraductal papillary mucinous neoplasms(IPMNs) have become commonly diagnosed.From a morphological standpoint,they are classified in main-duct IPMNs(MD-IPMNs) and branch-duct IPMNs(BD-IPMNs),depending on the type of involvement of the pancreatic ductal system by the neoplasm.Despite the fact that our understanding of their natural history is still incomplete,recent data indicate that MD-IPMNs and BD-IPMNs show significant differences in terms of biological behaviour with MD-IPMNs at higher risk of malignant degeneration.In the present paper,clinical and epidemiological characteristics,rates of malignancy and the natural history of MD-IPMNs and BD-IPMNs are analyzed.The profile of IPMNs involving both the main pancreatic duct and its side branches(combined-IPMNs) are also discussed.Finally,general recommendations for management based on these differences are given. | Roberto Salvia Stefano Crippa Stefano Partelli Giulia Armatura Giuseppe Malleo Marina Paini Antonio Pea Claudio Bassi | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 14 |
| 2 | Expression of liver cancer associated gene HCCA3显示文摘AIM: To study and clone a novel liver cancer reisted gene,and to explore the molecular basis of liver cancer genesis.METHODS: Using mRNA differential display polymerasechain reaction (DDPCR), we investigated the difference of mRNA in human hepatocellular carcinoma (HCC) and paired surrounding liver tissues, and got a gene probe. By screening a human placenta cDNA library and genomic homologous extend, we obtained a full-length cDNA named HCCA3. We analyzed the expression of this novel gene in 42pairs of HCC and the surrounding liver tissues, and distribution in human normal tissues by means of Northern blot assay.RESULTS: A full-length cDNA of liver cancer associated gene HCCA3 has been submitted to the GeneBank nucleotide sequence databases ( Accession No. AF276707 ). The positive expression rate of this gene was 78.6% (33/42) in HCC tissues, and the clinical pathological data showed that the HCCA3 was closely associated with the invasion of tumor capsule ( P = 0.023) and adjacant small metastasis satellite nodules lesions ( P= 0.041). The HCCA3 was widely distributed in the human normal tissues, which was intensively expressed in lungs, brain and colon tissues,while lowly expressed in the liver tissues.CONCLUSION: A novel full-length cDNA was cloned and differentiated, which was highly expressed in liver cancer tissues. The high expression was closely related to the tumor invasiveness and metastasis, that may be the late heredited change in HCC genesis. | Zheng-Xu Wang~1 Gui-Fang Hu~1 Hong-Yang Wang~2 Meng-Chao Wu~2 1 Department of General Surgery,Chinese PEA General Hospital of Lanzhou Military Command,Lanzhou 730050,Gansu Province,China2 Eastern Hepatobilliary Surgical Hospital,Second Military Medical University,Shanghai 200438,China | 2001 | World Journal of Gastroenterology2001，7，6： | 9 |
| 3 | PEComas: the past, the present and the future显示文摘 | Guido Martignoni Maurizio Pea Daniela Reghellin Giuseppe Zamboni Franco Bonetti | 2008 | Virchows Archiv2008，，2： | 4 |
| 4 | Ampulla of Vater carcinoma: Molecular landscape and clinical implications显示文摘Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well. | Antonio Pea Giulio Riva Riccardo Bernasconi Elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa Claudio Luchini | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 4 |
| 5 | Renal pathology in the tuberous sclerosis complex显示文摘 | Martignoni G Pea M Rocca P C | 2003 | Pathology2003，35，6： | 1 |
| 6 | Mineral/leucosome trace-element partitioning in a peraluminous migmatite (a laser ablation-ICP-MS study) 显示文摘 | Pea F Pereira M Stroh A | 1994 | Chemical Geology1994，117，14： | 1 |
| 7 | Chrysanthemum chlorotic mottle viroid RNA:dissection of the pathogenicity determinant and comparative fitness of symptomatic and non-symptomatic variants显示文摘 | Flores R | 2002 | J Mol Biol2002，321，： | 1 |
| 8 | Hyperlactacidemia potentially due to linezolid overexposure in a liver transplant recipient显示文摘 | Pea F Scudeller L Lugano M | 2006 | Clin Infect Dis2006，42，3： | 1 |
| 9 | Issues in pharmacokinetics and pharmacodynamics of anti-infective agents:distribution in tissue显示文摘 | Müller M dela Pea A Derendorf H | 2004 | Antimicrob Agents Chemother2004，48，： | 1 |
| 10 | PEComas: the past, the present and the future显示文摘 | Martignoni G Pea M Reghellin D | 2008 | Virchows Arch2008，452，2： | 1 |
| 11 | Comparison of the clinical efficacy and safety of carbamide peroxide and hydrogen peroxide in at-home bleaching gels显示文摘 | Alonso de la Pea V Balboa Cabrita O | 2006 | Quintessence Int2006，37，7： | 1 |
| 12 | Noninfectious pulmonary complications after hematopoietic stem cell transplantation:practical approach to imaging diagnosis显示文摘 | Pea E Souza CA Escuissato DL | 2014 | Radiographics2014，34，3： | 1 |
| 13 | Pharmacokinetics of two oral cyclosporine A formulations in clinically stable heart-transplant patients显示文摘 | BARALDO M PEA F POZ D | 2001 | Pharmacol Res2001，43，6： | 1 |
| 14 | Antimicrobial therapy in critically ill patients : a review of pathophysiological conditions responsible for altered disposition and pharmacokinetic variability显示文摘 | Pea F Viale P Furlanut M | 2005 | Clin Pharmacokinet2005，44，10： | 1 |
| 15 | Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity显示文摘 | Gago S Flores R | 2003 | EMBO J2003，22，： | 1 |
| 16 | PEComas:the past,the present and the future显示文摘 | MARTIGNONI G PEA M RGHELLEIN D | 2008 | Virchows Arch2008，52，4： | 1 |
| 17 | High vanco-mycin dosage regimens required by intensive care unit patients cotreated with drugs to improve haemodynamics following cardiac surgical procedures显示文摘 | PEA F PORRECA L BARALDO M | 2000 | J Antimicrob Chemother2000，45，3： | 1 |
| 18 | Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients显示文摘 | Pea F Viale P Cojutti P | 2012 | J Antimicrob Chemother2012，67，8： | 1 |
| 19 | Pharmacokinetic considerations for antimicrobial therapy in patients receiving eontinuous renal replacement therapy 显示文摘 | PEA F VIALE P PAVAN F | 2007 | Clin Pharmacokinet2007，46，12： | 1 |
| 20 | Integrating distributed generation into electric power systems : a review of drivers , challenges and opportunities显示文摘 | Peas Lopes J A Hatziargyriou N Mutale J | 2007 | Electric Power Systems Research2007，77，9： | 1 |
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