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	题名	作者	年代	出处	被引量
1	Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion显示文摘Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the lungs.However,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites.The in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical trial.Two patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h IVLP.In both pig and human cases,DOX tissue levels presented similar trends during IVLP.Human lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP procedure.In addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug administration.Real-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy approach.Bio-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy.	Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn	2021	Journal of Pharmaceutical Analysis2021，11，1：	3
2	Applications of solid-phase microextraction in food analysis显示文摘	Hiroyuki Kataoka Heather L Lord Janusz Pawliszyn	2000	Journal of Chromatography A2000，，1：	2
3	Solventless determination of caffeine in beverages using solid-phase microextraction with fused-silica fibers显示文摘	Hawthorne S B Miller D J Pawliszyn J	1992	Journal of chromatography1992，603，：	1
4	Headspace solid-phase microextraction-gas chromatographic-time-of- flight mass spectrometric methodology for geographical origin verification of coffee显示文摘	RISTICEVIC S CARASEK E PAWLISZYN J	2008	Analytica Chimica Acta2008，617，12：	1
5	Solid phase microextraction with thermal desorption using fused silica optical fibers 显示文摘	Pawliszyn J Arthur C L	1990	Anal Chem1990，62，：	1
6	Dual Detection for Capillary Isoelec-tric-Focusing with Refractive-Index Gradient and AbsorptionImaging Detectors显示文摘	WU J Q PAWLISZYN J	1994	Analytical Chemistry1994，66，：	1
7	Fast analysis of volatile organic compounds and disinfection by-products in drinking water using solid-phase mieroextraetion-gas chromatography/time-of-flight mass spectrometry 显示文摘	Niri V H Bragg L Pawliszyn J	2008	J Chromatogr A2008，1201，2：	1
8	Dynamics of organic compound extraction from water using liquid- coated fused silica fibers 显示文摘	Louch D Motlagh S and Pawliszyn J	1992	Anal Chem1992，64，10：	1
9	Automated in-tube solid-phase microextraetion coupled to high-performance liquid chromatography显示文摘	Eisert R Pawliszyn J	1997	Analytical chemistry1997，69，：	1
10	Solid- phase microextraction; a solvent-free alternative for sample preparation Anal 显示文摘	Zhang Z Yang M Pawliszyn J	1994	Chem1994，，66：	1
11	Solid-phase microextraction with thermal-desorption using fused-silica optical fibers显示文摘	Arthur C L Pawliszyn J	1990	Analytical Chemistry1990，62，19：	1
12	Solid phase microextraction with thermal desorption using fused silica optical fibers 显示文摘	ARTHUR C L PAWLISZYN J	1990	Anal Chem1990，62，：	1
13	Determination of butyltin species in water and sediment by solid-phase microextraction-gas chromatography-flame ionization detection显示文摘	Esmeralda Millan Janusz Pawliszyn	2000	J Chromatography A2000，873，1：	1
14	Solid phase microextraction coupled to high-performance liquid chromatography 显示文摘	CHEN J PAWLISZYN J	1995	Anal Chem1995，67，15：	1
15	Diode Laser-Based ConcentrationGradient Imaging Detector for Capillary Isoelectric-Focusing显示文摘	WU J Q PAWLISZYN J	1995	Analytica Chimica Acta1995，299，：	1
16	Solid phase raicroextraction with thermal desorption using fused silica optical fibers显示文摘	ARTHUR L PAWLISZYN J	1990	Anal Chem1990，62，：	1
17	Determination of tetraethyllead and inorganic lead in water by solid phase microextraction/gas chromatography显示文摘	Tadeusz Górecki Janusz Pawliszyn	1996	Anal Chem1996，68，17：	1
18	Headspace solid-phase microextraction显示文摘	Zhang Z Y and Pawliszyn J	1993	Anal Chem1993，65，14：	1
19	查看详情显示文摘	Cui S F Tan S Ouyang G F Pawliszyn J		0，，12：	1
20	Solid phase microextraction: a new solvent -free ahemative for sample preparation 显示文摘	ZHANG Z YANG M J PAWLISZYN J	1994	Anal Chem1994，66，：	1

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