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| 1 | The development and application of Laboratory Animal Science in China显示文摘The 14th Scientific Congress of the Chinese Association for Laboratory Animal Science was held on October 11‐12,2018 in Qingdao,China.During this congress,an international forum on the development of Laboratory Animal Sciences(LAS)worldwide was held in which participants learnt about the development of new LAS resources and technologies,as well as the progress of LAS in China.The main points that were discussed are as follows.After nearly a century of development,there are more than 200 species of experimental animals,and more than 20 000 inbred lines,outbred lines,genetic engineered animals,animal models of diseases,and other resources all over the world,which provide abundant experimental animal resources for scientific research.These resources are widely used in life science research. | Patri Vergara Grant Morahan | 2018 | Animal Models and Experimental Medicine2018，1，4： | 4 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Environmental regulation and productivity: testing the porter hypothesis显示文摘 | Paul Lanoie Michel Patry Richard Lajeunesse | 2008 | Journal of Productivity Analysis2008，，2： | 2 |
| 4 | ERCP-Directed Radiofrequency Ablation and Photodynamic Therapy Are Associated with Comparable Survival in the Treatment of Unresectable Cholangiocarcinoma显示文摘 | Daniel S. Strand Natalie D. Cosgrove James T. Patrie Dawn G. Cox Todd W. Bauer Reid B. Adams James A. Mann Bryan G. Sauer Vanessa M. Shami Andrew Y. Wang | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 5 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 6 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 7 | Meshed capillary vessels found on narrow-band imaging without optical magnification effectively identifies colorectal neoplasia: a North American validation of the Japanese experience显示文摘 | Zachary H. Henry Paul Yeaton Vanessa M. Shami Michel Kahaleh James T. Patrie Dawn G. Cox David A. Peura Fabian Emura Andrew Y. Wang | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 8 | Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat显示文摘 | Luis M. Moquillaza María-Angeles Aller Maria-Paz Nava Luis Santamaría Patri Vergara Jaime Arias | 2009 | Acta Histochemica2009，，4： | 1 |
| 9 | Dendritic polymer macromo-lecular carriers for drug delivery 显示文摘 | Patri A K Majoros I J Baker J R | 2002 | Curr Opin in Chem Bio2002，6，4： | 1 |
| 10 | The influence of peer feedback on self-and peer-assessment of oral skills 显示文摘 | Patri M | 2002 | Language Testing2002，，19： | 1 |
| 11 | Pressure Ap- plied on the Extral Acupuncture Point Reduces Bispec- tral Index Values and Stress in Volunteers 显示文摘 | Fassolaki A Paraskeva A Patris K | 2003 | AnesthAnalg2003，96，3： | 1 |
| 12 | Pressure applied on the extra 1 acupuncture point reduces bispectral index values and stress in volunteers显示文摘 | Fassoulaki A Paraskeva A Patris K | 2003 | Anesth Analg2003，96，3： | 1 |
| 13 | CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference,and digestive secretions 显示文摘 | Laugerette F Passilly-Degrace P Patris B | 2005 | J Clin Invest2005，115，11： | 1 |
| 14 | Targeted drug deliv- ery with dendrimers : comparison of the release kinetics of cova- lently conjugated drug and non-covalent drug inclusion complex 显示文摘 | Patri AK Kukowska-Latallo JF Baker JR | 2005 | Adv Drug Deliv Rev2005，57，15： | 1 |
| 15 | Subclinical 'electrical status epilepticus' induced by sleep in children显示文摘 | Patry G Lyagoubi S Tassinari CA | 1971 | Arch Neurol1971，24，3： | 1 |
| 16 | Citalopram and fluoxetine in major depression: comparison of two clinical trials in a psychiatrist setting and in general practice显示文摘 | Bougerol T Scotto JC Patris M | 1997 | Clin Drug Invest1997，14，： | 1 |
| 17 | Management of gestational diabetes mellitus and pharmacists' role in patient education显示文摘 | Evans E Patry R | 2004 | Am J Health Syst Pharm2004，61，14： | 1 |
| 18 | Ropivacaine attenuates pulmonary vasoconstriction induced by thromboxane A2 analogue in the isolated perfused rat lung显示文摘 | Fischer LG Honemann CW Patrie JT | 2000 | Reg Anesth Pain Med2000，25，2： | 1 |
| 19 | A dynamic model of the clarificationthickening process 显示文摘 | Takacs I Patry G Nolasco D | 1991 | Water Research1991，25，10： | 1 |
| 20 | 显示文摘 | Dalloul AH Patry C Salamero J | 1999 | J Immunol1999，162，10： | 1 |
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