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| 1 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 2 | Utility of D2-40,a novel mesothelial marker, in the diagnosis of maglinant mesothelioma显示文摘 | Chu A Y Litzky L A Pasha T L | 2005 | Mod Pathol2005，18，1： | 1 |
| 3 | Angiotensin converting enzyme insertion allele in relation to high altitude adaptation 显示文摘 | QADAR PASHA M A KHAN A P KUMAR R | 2001 | Annals of Human Genetics2001，65，6： | 1 |
| 4 | Double-balloon enteroscopy and capsule endoscopy have cmnparable diagnoslie yield in small-bowel dis- ease : a meta-analysis 显示文摘 | Pasha SF Leighton JA Das A | 2008 | Clin Gastroenterol Hepatol2008，6，6： | 1 |
| 5 | Variations in angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian populations of different ethnic origins显示文摘 | Pasha M A Qadar Khan Amjad P Kumar Ratan | 2002 | J Biosci2002，27，1： | 1 |
| 6 | Amberlite IR-120 catalyzed, micro?wave-assisted rapid synthesis of 2-aryl-benzimidazoles显示文摘 | Pasha M A Nizam A | 2012 | J Saudi Chem Soc2012，16，3： | 1 |
| 7 | Use of nonpolar resin for reduction of fluoranthene bioavailability in sediment显示文摘 | Kosian P A West C W Pasha M S | 1999 | Environmental Toxicology and Chemistry1999，18，2： | 1 |
| 8 | Rapid method of converting primaryamides to nitriles and nitriles to primary amides by ZnC\z usingmicrowaves under different reaction conditions 显示文摘 | Manjula K Pasha M A | 2007 | SynthesisCommunication2007，37，9： | 1 |
| 9 | Neurokinin-1 (NK-1) receptor is required in clostridium difficileinduced enteritis显示文摘 | RIEGLER M PASHA A | 1998 | J Clin Invest1998，101，8： | 1 |
| 10 | Correlation between hyperglycemia and reti- nopathy of prematurity 显示文摘 | MOUSA AK AUREZA JM SEYED AR JAHANGIR T BUANI A PASHA YZ | 2014 | Pediatr Int2014，56，5： | 1 |
| 11 | Utility of D2-40 a novel mesothelial marker in the diagnosis of malignant mesothelima显示文摘 | Chu A Y Litzky L A Pasha T L | 2005 | Mod Pathol2005，18，： | 1 |
| 12 | Genomics of high altitude adaptation and maladaptation显示文摘 | M A QADAR PASHA | 2004 | High Altitude Med Biol2004，5，2： | 1 |
| 13 | A Gaussian Mixture PHD Filter for Jump Markov System Models 显示文摘 | Pasha S A Vo B N Tuan H D | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，3： | 1 |
| 14 | Modelling of cracking sites/development in axial dovetail joints of aero-engine compressor discs显示文摘 | Hammouda M M I Pasha R A Fayed A S | 2007 | International Journal of Fatigue2007，29，1： | 1 |
| 15 | Development of polyclonal ELISA for the N-methylcarbamate insecticide bendiocarb显示文摘 | ANAND C PASHA A SWETHA M D | 2007 | Food and Agricultural Immunology2007，18，1： | 1 |
| 16 | Overexpression of p16INK4a in liquid-based specimens (SurePath) as marker of cervical dy splasis and neoplasia显示文摘 | Saqi A Pasha TL McG rath CM | 2002 | Diagn Cytopathol2002，27，6： | 1 |
| 17 | A Gaussian mixture PHD filter for jump Markov system models显示文摘 | Pasha S A Vo B N Tuan H D | 2009 | IEEE Trans on Aerospace and Electronic System2009，45，3： | 1 |
| 18 | Lntuitionistic fuzzy sets clustering(IFSC) with an application in psychology 显示文摘 | Pasha E A Fatemi A | 2006 | Journal of Mathematics and Applications2006，，28： | 1 |
| 19 | Phase coded hybrid waveform design for LPI radar显示文摘 | MAZUNU S PASHA I A REDDY P C | 2014 | INT J on Recent Trends in Engineering and Technology2014，11，1： | 1 |
| 20 | Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures显示文摘BACKGROUND The healthcare burden of inflammatory bowel disease(IBD)is rising globally and there are limited non-invasive biomarkers for accurate and early diagnosis.AIM To understand the important role that intestinal microbiota play in IBD pathogenesis and identify anti-microbial antibody signatures that benefit clinical management of IBD patients.METHODS We performed serological profiling of 100 Crohn’s disease(CD)patients,100 ulcerative colitis(UC)patients and 100 healthy controls against 1173 bacterial and 397 viral proteins from 50 bacteria and 33 viruses on protein microarrays.The study subjects were randomly divided into discovery(n=150)and validation(n=150)sets.Statistical analysis was performed using R packages.RESULTS Anti-bacterial antibody responses showed greater differential prevalence among the three subject groups than anti-viral antibody responses.We identified novel antibodies against the antigens of Bacteroidetes vulgatus(BVU_0562)and Streptococcus pneumoniae(SP_1992)showing higher prevalence in CD patients relative to healthy controls.We also identified antibodies against the antigen of Streptococcus pyogenes(SPy_2009)showing higher prevalence in healthy controls relative to UC patients.Using these novel antibodies,we built biomarker panels with area under the curve(AUC)of 0.81,0.87,and 0.82 distinguishing CD vs control,UC vs control,and CD vs UC,respectively.Subgroup analysis revealed that penetrating CD behavior,colonic CD location,CD patients with a history of surgery,and extensive UC exhibited highest antibody prevalence among all patients.We demonstrated that autoantibodies and anti-microbial antibodies in CD patients had minimal correlation.CONCLUSION We have identified antibody signatures for CD and UC using a comprehensive analysis of antimicrobial antibody response in IBD.These antibodies and the source microorganisms of their target antigens improve our understanding of the role of specific microorganisms in IBD pathogenesis and,after future validation,should aid early and accurate diagnosis of IBD. | Mahasish Shome Lusheng Song Stacy Williams Yunro Chung Vel Murugan Jin G Park William Faubion Shabana F Pasha Jonathan A Leighton Joshua LaBaer Ji Qiu | 2022 | World Journal of Gastroenterology2022，28，30： | 1 |
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