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| 1 | 中国肺癌死亡趋势分析及发病、死亡的估计与预测显示文摘背景与目的利用我国现有相对较完善的肺癌发病死亡资料,描述中国肺癌死亡趋势,并估计和预测2000年及2005年的肺癌发病与死亡状况,以期对我国肺癌临床、基础研究及防治策略制定提供依据及参考.方法利用Joinpoint模型对卫生部上报WHO的中国1987~1999年肺癌死亡数据进行趋势分析,结合我国1990~1992年第二次全死因调查结果及我国入选<五大洲癌症发病率>第八卷中肿瘤登记处的肺癌发病死亡数据,采用对数线性模型(基于Poisson分布),估计并预测2000年及2005年中国肺癌的发病、死亡状况.结果我国肺癌年龄调整死亡率总体呈上升趋势,尤以农村明显(男性年均上升2.7%,女性上升3.6%,均有统计学意义)且各年龄段(15岁以上)均呈不同程度上升趋势.自2000年至2005年,我国肺癌的死亡人数将增加10.1万(自2000年的32.7万增至2005年的42.8万),发病人数将增加11.6万(自2000年的38.1万增至2005年的49.7万).结论由于肺癌危险因素变化及人口增长、老龄化的双重作用,肺癌已成为中国近年来最常见、增幅最大的恶性肿瘤之一,其预防与控制将成为未来中国肿瘤控制计划制定和实施的重点之一,而控制烟草无疑成为其关键. | 杨玲 李连弟 陈育德 Donald Maxwell Parkin | 2005 | 中国肺癌杂志2005，8，4： | 167 |
| 2 | 东亚地区癌症负担和预防策略显示文摘目的:探讨东亚地区当前的癌症负担、危险因素、预防和控制策略。方法:应用全球癌症数据库和5大洲癌症发病资料,利用发病率、死亡率和患病率指标估计东亚地区的癌症负担,分析主要癌症的预防策略。结果:东亚地区癌症的年新发病例数为280万,死亡病例200多万,现患病例490万。最常见的5种癌症是胃癌、肺癌、肝癌、食管癌和结直肠癌,占东亚地区癌症年新发病例数的68%(分别占癌症年新发病例数的18.7%、16.9%、14.2%、9.4%和9.1%)。预计2050年的癌症新发病例数将达600万,死亡病例450万。结论:癌症是目前和今后东亚地区面临的严重公共卫生问题,必须贯彻以预防为主的方针。 | 蔡琳 GOLDSTEIN Binh Yang PARKIN Donald Maxwell 张作风 | 2008 | 肿瘤2008，28，5： | 36 |
| 3 | SJWD14121600000297显示文摘 | Jacques Ferlay Isabelle Soerjomataram Rajesh Dikshit Sultan Eser Colin Mathers Marise Rebelo Donald Maxwell Parkin David Forman Freddie Bray | 2015 | Int. J. Cancer2015，，5： | 31 |
| 4 | SJWD14121600000297显示文摘 | Jacques Ferlay Isabelle Soerjomataram Rajesh Dikshit Sultan Eser Colin Mathers Marise Rebelo Donald Maxwell Parkin David Forman Freddie Bray | 2015 | Cancer2015，，5： | 15 |
| 5 | Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders显示文摘Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders. | Georgia M Parkin Madhara Udawela Andrew Gibbons Brian Dean | 2018 | World Journal of Psychiatry2018，8，2： | 9 |
| 6 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 7 | Estimates of cancer incidence and mortality in Europe in 2008显示文摘 | J. Ferlay D.M. Parkin E. Steliarova-Foucher | 2009 | European Journal of Cancer2009，，4： | 5 |
| 8 | Cancer burden in the year 2000. The global picture显示文摘 | D.M Parkin F.I Bray S.S Devesa | 2001 | European Journal of Cancer2001，，： | 5 |
| 9 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 10 | Global cancer statistics,2002显示文摘 | Parkin DM Bray F Ferlay J | | CA:A Cancer Journal for Clinicians0，，： | 4 |
| 11 | Transgranular stress corrosion cracking of high - pressure pipelines in contact with solutions of near neutral pH显示文摘 | Parkins R N Blanchard W K Jr Delanty B S | 1994 | Corrosion1994，50，5： | 4 |
| 12 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 13 | Global cancer statistics in the year 2000显示文摘 | D Maxwell Parkin | 2001 | Lancet Oncology2001，，9： | 3 |
| 14 | Global cancer statistics in the year 2000显示文摘 | Parkin DM | | LANCET ONCOLOGY0，，： | 3 |
| 15 | Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions显示文摘 | Isabelle Soerjomataram Joannie Lortet-Tieulent D Maxwell Parkin Jacques Ferlay Colin Mathers David Forman Freddie Bray | 2012 | The Lancet2012，，9856： | 3 |
| 16 | Cancer burden in the year 2000. The global picture显示文摘 | D.M Parkin F.I Bray S.S Devesa | 2001 | European Journal of Cancer2001，，： | 3 |
| 17 | Global cancer statistics in the year 2000显示文摘 | D Maxwell Parkin | 2001 | Lancet Oncology2001，，9： | 3 |
| 18 | Estimating the world cancer burden:Globocan 2000显示文摘 | Parkin DM Bray F Ferlay J | | 0，，02： | 2 |
| 19 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 20 | Global cancer statistiea, 2002 显示文摘 | Parkin DM Bray F Ferlay J | 2005 | CA Cancer J Clin2005，55，2： | 1 |
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