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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 3 | Emulsifying properties of high pressure treated soy protein isolate and 7S and l1S globulins显示文摘 | Molina E Papadopoulou A Ledward D A | 2001 | Food Hydrocolloid2001，15，3： | 1 |
| 4 | Previous experience influences pacing during 20 km time trial cycling 显示文摘 | MICKWRIGHT D PAPADOPOULOU E SWART J | 2010 | Br J Sports Med2010，44，： | 1 |
| 5 | Survival of enterobacteria in liquid cultures during microwave radiation and conventional heating 显示文摘 | C Papadopoulou D Demetriou A Panagiou | 1995 | Microbiol Res1995，150，3： | 1 |
| 6 | Parsing strategies in L1 and L2 sentence processing:A study of relative clause attachment in Greek显示文摘 | CLAHSEN H | 2003 | Studies in Second Language Acquisition2003，25，4： | 1 |
| 7 | Effect of cyclosporine therapy with low doses of corticosteroids on idiopathic nephritic syndrome显示文摘 | Griveas I Visvardis G Papadopoulou D | 2010 | Artif Organs2010，34，3： | 1 |
| 8 | Primary retroperitoneal mucinous cysta- denoma显示文摘 | PAPADOPOULOU D CHATZI RALLI I FILITAT- ZI CH | 2011 | Hippokratia2011，15，2： | 1 |
| 9 | Load application induces changes in the expression levels of Box-9, FGFR-3 and VEGF in condylar ehon- drocytes显示文摘 | Papadopoulou AK Papachristou D J Chatzopoulos SA | 2007 | FEBS Lett2007，581，10： | 1 |
| 10 | Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor显示文摘 | Cao J Papadopoulou N Kempuraj D Boucher WS Sugimoto K Cetrulo CL et a1 | 2005 | J Immunol2005，174，： | 1 |
| 11 | Critical area computation via Voronoi diagrams 显示文摘 | PAPADOPOULOU E LEE D T | 1999 | IEEE Trans Comp Aid Des Integr Circ and Syst1999，18，4： | 1 |
| 12 | Emulsifying properties of high pressure treated soy protein isolate and 7S and 11S globulins显示文摘 | E Molina A Papadopoulou D A Ledward | 2001 | Food Hydrocolloids2001，15，： | 1 |
| 13 | Critical Area Computation via Voronoi Diagrams 显示文摘 | Papadopoulou E Lee D T | 1999 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1999，18，4： | 1 |
| 14 | The rloe of timely interventim middle Lobe syndrome in children显示文摘 | Priftis KN Mermiri D Papadopoulou A | 2005 | Chest2005，128，： | 1 |
| 15 | Increased numbers of activated mast cellsin endometriosis lesions positive for corticotropin-rele asing hormone and urocortin 显示文摘 | KEMPURAJ D PAPADOPOULOU N STANDFORDEJ | 2004 | Am JReprod Immunol2004，52，4： | 1 |
| 16 | Metadata-based heritage sites modeling with e-learning functionality显示文摘 | Styliadis A D Akbaylar I I Papadopoulou D A | 2009 | Journal of Cultural Heritage2009，10，2： | 1 |
| 17 | Emulsifyingproperties of high pressure treated soy protein isolate and 7Sand 11S globulins显示文摘 | Molina E Papadopoulou A Ledward D | 2001 | Food Hydrocolloids2001，15，3： | 1 |
| 18 | Increased aquaporin-1 water channel expresson in human brain tumors显示文摘 | Saadoun S Papadopoulous M Davies D | 2002 | Br J Cancer2002，87，： | 1 |
| 19 | Emulsifying properties of high pressuretreated soy protein isolate and 7S and 11S globulins显示文摘 | Molina E Papadopoulou A Ledward D A | | 0，，03： | 1 |
| 20 | Emulsifyingproperties of high-pressure treated soy protein isolates and 7S and11S globulins显示文摘 | Molina E Papadopoulou A Ledward D A | 2001 | Food Hydrocolloids2001，15，3： | 1 |
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