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| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | Bone and high-density lipoprotein:The beginning of a beautiful friendship显示文摘There is a tight link between bone and lipid metabolic pathways.In this vein,several studies focused on the exploration of high-density lipoprotein(HDL)in the pathobiology of bone diseases,with emphasis to the osteoarthritis(OA)and osteoporosis,the most common bone pathologies.Indeed,epidemiological and in vitro data have connected reduced HDL levels or dysfunctional HDL with cartilage destruction and OA development.Recent studies uncovered functional links between HDL and OA fueling the interesting hypothesis that OA could be a chronic element of the metabolic syndrome.Other studies have linked HDL to bone mineral density.Even though at epidemiological levels the results are conflicting,studies in animals as well as in vitro experiments have shown that HDL facilitates osteoblastogensis and bone synthesis and most probably affects osteoclastogenesis and osteoclast bone resorption.Notably,reduced HDL levels result in increased bone marrow adiposity affecting bone cells function.Unveiling the mechanisms that connect HDL and bone/cartilage homeostasis may contribute to the design of novel therapeutic agents for the improvement of bone and cartilage quality and thus for the treatment of related pathological conditions. | Dionysios J Papachristou Harry C Blair | 2016 | World Journal of Orthopedics2016，7，2： | 3 |
| 3 | Behavioral Testability Insertion for Datapath/Controller Circuits显示文摘 | Carletta J Papachristou C A | 1997 | Journal of Electronic Testing:Theory and Applications1997，11，： | 2 |
| 4 | An FPGA-based Computing Platform for Real-time 3D Medical Imaging and Its Application to Cone-beam CT Reconstruction显示文摘 | Li Jianchun Papachristou C Shekhar R | 2005 | Journal of Imaging Science and Technology2005，49，3： | 1 |
| 5 | Predictors of severity and necrosis in acute pancreatictics 显示文摘 | Papachristou G I Whitcomb D C | 2004 | Castroenterol Clin North Am2004，33，4： | 1 |
| 6 | False path exclusion in delay analysis of RTL structures显示文摘 | Nourani M Papachristou C A | 2002 | IEEE Transactions on Very Large Scale Integration Systems2002，10，1： | 1 |
| 7 | Impaired psychosocial outcome of donors after living donor liver transplantation : a qualitative case study显示文摘 | walter M Papachristou C Pascher A | 2006 | Clin Transplant2006，20，4： | 1 |
| 8 | EUS fea- tures of annular pancreas (with video)显示文摘 | Papachristou G I Topazian M D Gleeson F C | 2007 | Gastrointest Endosc2007，65，2： | 1 |
| 9 | Early weight beating after posterior malleolar fractures: an experimental and prospective clinical study 显示文摘 | Papachristou G Efstathopoulos N Levidiotis C | 2003 | J Foot Ankle Surg2003，2，： | 1 |
| 10 | Soluble E-cadherin as a diagnostic and prognostic marker in gas- tric carcinoma显示文摘 | Tsalikidis C Papachristou F Pitiakoudis M | 2013 | Folia Med2013，55，34： | 1 |
| 11 | Collision-Free Operation in Ad hoc Carrier Sense Multiple Access Wireless Networks显示文摘 | Papachristou C Pavlidou F N | 2002 | Communications Letters IEEE2002，6，8： | 1 |
| 12 | Dissection of appetitive conditionine Does impulsivity play a role? 显示文摘 | Papachristou H Nederkoorn C Beunen S | 2013 | Appetite2013，，69： | 1 |
| 13 | An FPGA-based computing platform for real-time 3D medical imaging and its applica- tion to conebeam CT reconstruction显示文摘 | Li Jianchun Papachristou C Shekhar R | 2007 | IEEE Transactions on Information Technology2007，，： | 1 |
| 14 | Transgenic increase of Wnt7b in neural progenitor cells decreases expression of T-domain transcription factors and impairs neuronal differentiation 显示文摘 | Papachristou P Dyberg C Lindqvist M | 2014 | Brain Res2014，1576，： | 1 |
| 15 | Early weight bearing after posterior malleolar fractures:An experimental and prospective clinical study显示文摘 | Papachristou G Efstathopoulos N Levidiotis C | 2003 | J Foot Ankle Surg2003，42，2： | 1 |
| 16 | Willingness to donate:an interview study before liver transplantation显示文摘 | WAL TER M PAPACHRISTOU C DANZER G | 2004 | J Med Ethics2004，30，： | 1 |
| 17 | Designing paced assembly lines with fixed number of sta-tions显示文摘 | UGURDAG H F RACHAMADUGU R PAPACHRISTOU C A | | 0，，03： | 1 |
| 18 | Early weight bearing after posterior malleolar fracture : an experimental and propective clinical study 显示文摘 | Papachristou G Esftathopoulos N Levidiotis C | 2003 | Foot Ankle Surg2003，2，： | 1 |
| 19 | Willingness to donate:aninterview study before liver transplantation显示文摘 | Walter M Papachristou C Danzer G | 2004 | J Med Ethics2004，30，6： | 1 |
| 20 | Cysteamine-induced reduction in tissue somatostatin immunoreactivity is associated with alterations in somatostatin mRNA显示文摘 | Liu J L Patel Y C | 1994 | Regul Pept1994，49，： | 1 |
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