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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The diameter of undirected graphs associated to plane tessellations显示文摘 | YEBRA J A L FIOL M A MORILLO P | 1985 | Ars Combinatoria1985，20，： | 1 |
| 3 | Analyzing theperformance of a cluster-based architecture for immersivevisualization systems 显示文摘 | Morillo P Bierbaum A Hartling P | 2003 | Journal ofParallel and DistributedComputing2003，68，2： | 1 |
| 4 | Evaluation of population parameters and mathematical strategies for the calculation of prenatal risk of Down syndrome in the first trimester of pregnancy 显示文摘 | MART GARdA B P CALVO F M | 2012 | Prenatal Diagnosis2012，32，3： | 1 |
| 5 | Improved Certificate-based Encryption in the Standard Model显示文摘 | Galindo D Morillo P Rdfols C | 2008 | Journal of System and Software2008，81，7： | 1 |
| 6 | Locally constrained synthetic LoDs generation for natural terrain meshes 显示文摘 | M Perez M Fernandez P Morillo I Coma | 2004 | Future Generation Computer Systems (S0167-739X)2004，20，8： | 1 |
| 7 | Retention of copper by a calcareous soil and its textural fractions: Influence of amendment with two agroindustrial residues显示文摘 | Rodriguez-rubio P Morillo E Madrid L Undabeytia T Maqueda C | 2003 | European Journal of Soil Science2003，5，： | 1 |
| 8 | Somatic tetraploidy in specific click retinal ganglion cells induced by nerve growth factor显示文摘 | Morillo SM Escoll P de la Hera A | 2010 | Proc Natl Acad Sci2010，107，1： | 1 |
| 9 | The diameter of undirected graphs associated to plane tessellations显示文摘 | YEBRA J A L FIOL M A MORILLO P | 1985 | Ars Combinatoria1985，20，2： | 1 |
| 10 | Analyzing the performance of acluster-based architecture for immersive visualization systems显示文摘 | Morillo P Bierbaum A Hartling P | 2008 | Jour-nal of Parallel and Distributed Computing2008，68，2： | 1 |
| 11 | Leaching of 2, 4-D from a Soil in the Presence of β-Cyclodextrin: Laboratory Columns Experiments 显示文摘 | MORILLO E MARTiNEZ J I P GINES J M | 2001 | Chemosphere2001，44，： | 1 |
| 12 | Improved certificate-based en- cryption in the standard model显示文摘 | Galindo D Morillo P Rafols C | 2008 | The Journal of Systems and Software2008，81，： | 1 |
| 13 | Locally constrained synthetic LoDs generation for natural terrain meshes 显示文摘 | Perez M Fernandez M Morillo P | 2004 | Future Generation Computer Systems2004，20，： | 1 |
| 14 | Improved certificate-based encryption in the standard model 显示文摘 | Galindo D: Morillo P Rdfols C | 2008 | Journal of Systems and Software2008，81，7： | 1 |
| 15 | Cryptographic techniques for mobile ad-hoc networks显示文摘 | Daza V Herranz J Morillo P | 2007 | Computer Networks:The International Journal of Computer and Telecommunications Networking2007，51，18： | 1 |
| 16 | Eruptive clear cell acanthoma显示文摘 | Morillo V Manrique P Zabalza I | 2009 | Actas Dermosifiliogr2009，100，3： | 1 |
| 17 | A genetic approach for adding QoS to distributed virtual environments 显示文摘 | S Rueda P Morillo J M Orduna J Duato | 2007 | Nature -Inspired Distributed Computing Feb 262007，30，4： | 1 |
| 18 | On Dynamic Distribution of Private Keys over MANETs显示文摘 | Daza V Morillo P Rafols C | 2007 | Electronic Notes in Theoretical Computer Science(ENTCS)2007，171，1： | 1 |
| 19 | The diameter of undirected graphs associated to plane tessellations显示文摘 | Yebra J A L Fiol M A Morillo P | 1985 | Ars Combinatoria1985，20，： | 1 |
| 20 | A comparison study of modem heuristics for solving the partitioning problem in distributed virtual environment systems显示文摘 | P Morillo M Fernandez and J M Orduna | 2004 | Parallel Computing May/June2004，30，56： | 1 |
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