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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 3 | Recommender system显示文摘 | Resnick P Hal R V | 1997 | Commu- nications of the A CM1997，40，3： | 1 |
| 4 | Theorems like Sylow's显示文摘 | P Hal | 1956 | Proc London Math Soc1956，6，3： | 1 |
| 5 | Photoinduced electron transfer from conjugated polymers to TiO2显示文摘 | Paul A van Hal Marwijn P T Christiaans | 1999 | J Phys Chem B1999，103，21： | 1 |
| 6 | Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway 显示文摘 | Liang P Yu LR H Hal | 2009 | Carcinogenesis2009，30，10： | 1 |
| 7 | Lois De Pertes De Charge Dans Les Conduits Karstiques: Base Th6orique Et Observations显示文摘 | Jeannin P Y Mar&hal J C | 1995 | Bulletin D'' Hydrog6- ologie De 1'' Universit6 De Neuchfitel1995，14，： | 1 |
| 8 | Cytokinininduced photomorphogenesis in dark-grown Arabidopsis:a proteomic analysis显示文摘 | Lochmanová G Zdráhal Z Konecná H Koukalova S Malbeck J Soucek P Válková M Kiran N.S Brzobohaty B | | 0，，： | 1 |
| 9 | Effect of terlipressin on hepatorenal syndrome in cirrhotic patients : results of a multicentre pilot study显示文摘 | Hal irul C Bonnard P Bemars B | 2002 | Eur J Gastroenterol Hepaol2002，14，： | 1 |
| 10 | Biological hydrogen production,fundamentals and limiting processes显示文摘 | Hal enbeck P C Benemann J R | | 0，，： | 1 |
| 11 | 1-n-Butyl-3-methylimidazolium () octylsulfate-an even 'greener' ionic liquid显示文摘 | WASSERSCHEID P HAL R V BOSMANN A | 2002 | Green Chem2002，4，： | 1 |
| 12 | An impulsive receptance technique for the time domain computation of the vibration of a whole aero-engine model with nonlinear bearings显示文摘 | Hal P M Bonello P | 2008 | Journal of Sound and Vibration2008，318，3： | 1 |
| 13 | Kinetics of thermal degradation of vitamin C in marula fruit (Sclerocarya birrea subsp, caffra) as compared to other selected tropical fruits 显示文摘 | Hal H P Bosschaart C Twisk V C | 2012 | LWT-Food Science and Technology2012，49，2： | 1 |
| 14 | Systematic review of the incidence and prevalence of genital warts 显示文摘 | Patel H Wagner M Sing hal P | 2013 | BMC Infect Dis2013，13，8： | 1 |
| 15 | Interaction of Dr adhesion with collagen type IV is a critical step in Escherichia coli renal persistence 显示文摘 | Selvarangan R Goluszko P Sing hal J | 2004 | Infect Immun2004，72，8： | 1 |
| 16 | Influence of the molecular weight distribution on the percolation threshold of carbon nanotube-polystyrene composites显示文摘 | Hermant M C Smeets N M B Meuldijk J van Hal R C F Heuts H P A Klumperman B van Herk A M Koning C E | 2009 | E-polymers2009，2009，22： | 1 |
| 17 | New,functionalized ionic liquids from Michael-type reactions:A chance for combinatorial ionic liquid development显示文摘 | Wasserscheid P Driessen-H(o)1scher B Roy van Hal | | 0，，： | 1 |
| 18 | Continuous fixed-bed gas-phase hydroformylation using supported ionic liquid-phase(SILP) Rh catalysts显示文摘 | Riisager A Wasserscheid P Hal R | 2003 | J Catal2003，219，： | 1 |
| 19 | 显示文摘 | van Duren J K J Dhanabalan A van Hal P A | 2001 | Synth Met2001，121，： | 1 |
| 20 | Leveraging Social Book-marks from Partially Tagged Corpus for Improved Web- page Cluste-ring 显示文摘 | Trivedi A Rai P Hal Daum$ III | 2011 | ACM Transactions on Intelligent Systems and Technology2011，2，3： | 1 |
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