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| 1 | Are probiotics useful in Helicobacter pylori eradication?显示文摘Helicobacter pylori(H. pylori) is considered an etiologic factor for the development of peptic ulcer disease,gastric adenocarcinoma, and MALT lymphoma.Therapeutic schemes to eradicate the bacteria are based on double antibiotic therapy and proton pump inhibitor. Despite many therapeutic improvements in H. pylori eradication treatment, it is still associated with high infection rate also in developed countries.Bacterial resistance and adverse events occurrence are among most frequent causes for anti- H. pylori treatment failure. Several studies have reported that certain probiotic strains can exhibit inhibitory activity against H. pylori bacteria. In addition, some probiotic strains can reduce the occurrence of side effects due to antibiotic therapy and consequently increase the H.pylori eradication rate. The results of the prospective double-blind placebo-controlled studies suggest that specific probiotics, such as S. boulardii and L.johnsonni La1 probably can diminish the bacterial load,but not completely eradicate the H. pylori bacteria.Furthermore, it seems that supplementation with S. boulardii is a useful concomitant therapy in the standard H. pylori eradication treatment protocol and most probably increases eradication rate. L. reuteri is equally effective, but more positive studies are needed. Finally, probiotic strains, such as S. boulardii,L. reuteri and L. GG, decrease gastrointestinal antibiotic associated adverse effects. | Matjaz Homan Rok Orel | 2015 | World Journal of Gastroenterology2015，21，37： | 29 |
| 2 | Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease显示文摘It has been presumed that aberrant immune response to intestinal microorganisms in genetically predisposed individuals may play a major role in the pathogenesis of the inflammatory bowel disease, and there is a good deal of evidence supporting this hypothesis. Commensal enteric bacteria probably play a central role in pathogenesis, providing continuous antigenic stimulation that causes chronic intestinal injury. A strong biologic rationale supports the use of probiotics and prebiotics for inflammatory bowel disease therapy. Many probiotic strains exhibit anti-inflammatory properties through their effects on different immune cells, proinflammatory cytokine secretion depression, and the induction of anti-inflammatory cytokines. There is very strong evidence supporting the use of multispecies probiotic VSL#3 for the prevention or recurrence of postoperative pouchitis in patients. For treatment of active ulcerative colitis, as well as for maintenance therapy, the clinical evidence of efficacy is strongest for VSL#3 and Escherichia coli Nissle 1917. Moreover, some prebiotics, such as germinated barley foodstuff, Psyllium or oligofructose-enriched inulin, might provide some benefit in patients with active ulcerative colitis or ulcerativecolitis in remission. The results of clinical trials in the treatment of active Crohn's disease or the maintenance of its remission with probiotics and prebiotics are disappointing and do not support their use in this disease. The only exception is weak evidence of advantageous use of Saccharomyces boulardii concomitantly with medical therapy in maintenance treatment. | Rok Orel Tina Kamhi Trop | 2014 | World Journal of Gastroenterology2014，20，33： | 27 |
| 3 | Review on sedation for gastrointestinal tract endoscopy in children by non-anesthesiologists显示文摘AIM: To present evidence and formulate recommendations for sedation in pediatric gastrointestinal(GI) endoscopy by non-anesthesiologists.METHODS: The databases MEDLINE, Cochrane and EMBASE were searched for the following keywords 'endoscopy, GI', 'endoscopy, digestive system' AND 'sedation', 'conscious sedation', 'moderate sedation', 'deep sedation' and 'hypnotics and sedatives' for publications in English restricted to the pediatric age. We searched additional information published between January 2011 and January 2014. Searches for(upper) GI endoscopy sedation in pediatrics and sedation guidelines by non-anesthesiologists for the adult population were performed. RESULTS: From the available studies three sedation protocols are highlighted. Propofol, which seems to offer the best balance between efficacy and safety is rarely used by non-anesthesiologists mainly because of legal restrictions. Ketamine and a combination of a benzodiazepine and an opioid are more frequently used. Data regarding other sedatives, anesthetics and adjuvant medications used for pediatric GI endoscopy are also presented.CONCLUSION: General anesthesia by a multidisciplinary team led by an anesthesiologist is preferred. The creation of sedation teams led by non-anesthesiologists and a careful selection of anesthetic drugs may offer an alternative, but should be in line with national legislation and institutional regulations. | Rok Orel Jernej Brecelj Jorge Amil Dias Claudio Romano Fernanda Barros Mike Thomson Yvan Vandenplas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 4 | High-resolution MR imaging of the breast:clinical context 显示文摘 | Orel S G Hochman M G Schnall M D | 1996 | Radiographics1996，16，3： | 1 |
| 5 | MR imaging of the breast for the detection,diagnosis and staging of breast cancer显示文摘 | Orel S G Schnall M D | | 0，，01： | 1 |
| 6 | High-resolution MR imaging of the breast for the detection,diagnosis and staging of breast cancer显示文摘 | Orel S G | 1998 | Radiographics1998，18，8： | 1 |
| 7 | Gender differences in tumor necrosis factor alpha and leptin secretion from subcutaneous and visceral fatt issue显示文摘 | Orel M Lichnovska R Gwozdziew iczova S | 2004 | Physiol Res2004，53，5： | 1 |
| 8 | Suspicious breast lesions:MR imaging withradiologic-pathologic correlation显示文摘 | Orel SG Schnall MD Livolsi VA | 1994 | Radioloyg1994，190，： | 1 |
| 9 | High-resolution MR imaging for the detection,diagnosis,and staging of breast cancer显示文摘 | Orel SG | 1998 | Radiographics1998，18，4： | 1 |
| 10 | BI-RADS categorization as a predictor of malignancy显示文摘 | Orel SG Kay N Reynolds C | 1999 | Radiology1999，211，3： | 1 |
| 11 | Prevalence of the Helicobacter pylori babA2 gene and correlation with the degree of gastritis in infected Slovenian children显示文摘 | Matja? Homan Anja ?terbenc Bo?tjan J. Kocjan Bo?tjan Luzar Nina Zidar Rok Orel Mario Poljak | 2014 | Antonie van Leeuwenhoek2014，，4： | 1 |
| 12 | 显示文摘 | Krasovec U O Orel B | 2000 | Applied Catalysis B: Environmental2000，28，： | 1 |
| 13 | Relationship of breast magnetic resonance imaging to outcome after breastconservation treatment with radiation for women with earlystage invasive breast carcinoma or ductal carcinoma in situ显示文摘 | Solin lJ Orel SG Hwang WT | 2008 | J Clin Oncol2008，26，3： | 1 |
| 14 | Characterization of spinel Co3O4 and Li-doped Co3O4 thin film electrocatalysts prepared by the sol-gel route显示文摘 | SVEGL F OREL B SVEGL I G | 2000 | Electrochimica Acta2000，45，2526： | 1 |
| 15 | MR imaging-guided 9-gauge vacuum-assisted core-needle breast biopsy:initial experience显示文摘 | Orel SG Rosen M Mies C | 2005 | Radiology2005，238，1： | 1 |
| 16 | MR imaging of ductal carcinoma in situ 显示文摘 | Mendonea MH Reynolds C | 1997 | Radiology1997，202，： | 1 |
| 17 | Breast MR imaging:interpretation model显示文摘 | Nunes LW Schnall MD Orel SG | 1997 | Radiology1997，202，3： | 1 |
| 18 | Breast MR imaging interpretation model显示文摘 | Nunes LW Schnall MD Orel SC | 1997 | Radiology1997，202，： | 1 |
| 19 | Relationship of breast magnetic resonance imaging to outcome after breast con- servation treatment with radiation for women with early stage invasive breast carcinoma or ductal carcinoma in situ显示文摘 | Solin LJ Orel SG Hwang WT | 2008 | Clin Onco12008，26，3： | 1 |
| 20 | The effect of polyhe- dral oligomeric silsesquioxane dispersant and low surface energy additives on spectrally selective paint coatings with self-cleaning properties显示文摘 | JERMAN I KO2ELJ M OREL B | 2010 | Solar Energy Materials and Solar Cells2010，94，2： | 1 |
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