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| 1 | 激动人心的丙肝治疗革命显示文摘最新公布的III期临床数据显示,telaprevir——首个治疗丙肝的蛋白酶抑制剂,显著提高了丙肝的治愈率,给丙肝药物研发带来了美好的前景。 | Alisa Opar 朱宝益 | 2010 | 中国处方药2010，，7： | 2 |
| 2 | Mixed results for disease-modification strate- gies for Alzheimer's disease显示文摘 | OPAR A | 2008 | Nat Rev Drug Dis- cov2008，7，9： | 1 |
| 3 | Apoptosis induced by chelation of intraceUular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes 显示文摘 | Nakatani T Tawaramoto M Opare Kennedy D | 2000 | Chem Biol Interac2000，125，3： | 1 |
| 4 | Acute coronary syndrome and cardiac arrest:using simulation to assess resident performance and program outcomes显示文摘 | Opar SP Short MW Jorgensen JE | | 0，，03： | 1 |
| 5 | Environmental and multi-host infestation of the brown dog tick,Rhipicephalus sanguineus in Owerfi,South--east Nigeria a case report显示文摘 | Okolil I C Okoli C G and Oparal M | 2006 | Veterinarski Arhiv2006，76，1： | 1 |
| 6 | Novel anticancer strategy targets DNA repair显示文摘 | OPAR A | 2009 | Nat Rev Drug Discov2009，8，6： | 1 |
| 7 | New HIV drug classes on the horizon显示文摘 | OPAR A | 2007 | Nat Rev Drug Diseov2007，6，4： | 1 |
| 8 | Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases显示文摘 | Opare Kennedy D Kojima A Hasuma T | 2001 | Chem Biol Inter2001，134，2： | 1 |
| 9 | Detection and Tracking of Targets Against a Cloudscene Background Using Space -based Sensors 显示文摘 | Jordan P M Hsu S M Opar T P | 2000 | IEEE Aerospace Conference Proceedings2000，1，3： | 1 |
| 10 | Qualitative evaluation of the outcomes of care and treatment for children and adolescents with nodding syndrome and other epilepsies in Uganda显示文摘Background:In 2012,the Ugandan Government declared an epidemic of Nodding Syndrome(NS)in the Northern districts of Gulu,Kitgum,Lamwo and Pader.Treatment guidelines were developed and NS treatment centres were established to provide symptomatic control and rehabilitation.However,a wide gap remained between the predefined care standards and the quality of routine care provided to those affected.This study is to qualitatively assess adherence to accepted clinical care standards for NS;identify gaps in the care of affected children and offer Clinical Support Supervision(CSS)to Primary Health Care(PHC)staff at the treatment centres;and identify psychosocial challenges faced by affected children and their caregivers.Methods:This case study was carried out in the districts of Gulu,Kitgum,Lamwo and Pader in Uganda from September to December in 2015.Employing the 5-stage approach of Clinical Audit,data were collected through direct observations and interviews with PHC providers working in public and private-not-for-profit health facilities,as well as with caregivers and political leaders.The qualitative data was analysed using Seidel model of data processing.Results:Clinical Audit and CSS revealed poor adherence to treatment guidelines.Many affected children had suboptimal NS management resulting in poor seizure control and complications including severe burns.Root causes of these outcomes were frequent antiepileptic drugs stock outs,migration of health workers from their work stations and psychosocial issues.There was hardly any specialized multidisciplinary team(MDT)to provide for the complex rehabilitation needs of the patients and a task shifting model with inadequate support supervision was employed,leading to loss of skills learnt.Reported psychosocial and psychosexual issues associated with NS included early pregnancies,public display of sexual behaviours and child abuse.Conclusions:Despite involvement of relevant MDT members in the development of multidisciplinary NS guidelines,multidisciplinary care was not implemented in practice.There is urgent need to review the NS clinical guidelines.Quarterly CSS and consistent anticonvulsant medication are needed at health facilities in affected communities.Implementation of the existing policies and programs to deal with the psychosocial and psychosexual issues that affect children with NS and other chronic conditions is needed. | Catherine Abbo Amos Deogratius Mwaka Bernard Toliva Opar Richard Idro | 2019 | Infectious Diseases of Poverty2019，8，2： | 1 |
| 11 | Detection and Tracking of Targets Against a Cloudscene Background Using Space-Based Sensors 显示文摘 | Michael P Jordan Su May Hsu Opar T P | 2000 | IEEE Aerospaee Conference Proceedings2000，1，3： | 1 |
| 12 | Green tea extract inhibit angiogenesis of human umbilical vein endothelial cells through reduction of expression of VEGF receptors显示文摘 | Akiko Kojima-Yuasa Jin Jin Hua David Opare Kennedy | 2003 | Life Sciences2003，73，： | 1 |
| 13 | 糖尿病新药审批门槛提高?显示文摘在FDA做出批准文迪雅继续在市场上销售的决定后,2型糖尿病药物的发展将会发生怎样的变化? | Alisa Opar 阴慧娟 | 2007 | 中国处方药2007，6，9： | 1 |
| 14 | Growth inhibitory effect of green tea extract and (-) -epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases显示文摘 | Opare Kennedy D Ko jima A Hasuma T | 2001 | Chem Biol Inter2001，134，2： | 1 |
| 15 | Is nodding syndrome an Onchceerca volvulus induced neuro-inflammatory disorder? Uganda's story of research in understanding the disease 显示文摘 | Idro R Opar B Wamala J | 2016 | Int J Infect Dis2016，45，： | 1 |
| 16 | New class of kinase inhibitors poised to join theanticancer arsenal 显示文摘 | Opar A | 2012 | Nat Rev Drug Discov2012，11，11： | 1 |
| 17 | Mixed results for disease-modification strategies for Alzheimer's disease显示文摘 | OPAR A | 2008 | Nat Rev Drug Discov2008，7，9： | 1 |
| 18 | Apoptosisinduced by chelation of intracellular zinc is associated with depletionof cellular reduced glutathione level in rat hepatocytes 显示文摘 | Nakatani T Tawaramoto M Opare Kennedy D | 2000 | ChemBiol Interact2000，125，3： | 1 |
| 19 | Detection and tracking of targets against a cloudscene background using space-based sensors显示文摘 | Su May Hsu Opar T P | 2000 | IEEE Aerospace Conference Proceedings2000，1，3： | 1 |
| 20 | Prevalence and incidence of nodding syndrome and other forms of epilepsy in onchocerciasis-endemic areas in northern Uganda after the implementation of onchocerciasis control measures显示文摘Background:Around 2007,a nodding syndrome(NS)epidemic appeared in onchocerciasis-endemic districts of northern Uganda,where ivermeain mass distribution had never been implemented.This study evaluated the effect of community-directed treatment with ivermectin(CDTI)and ground larviciding of rivers initiated after 2009 and 2012 respectively,on the epidemiology of NS and other forms of epilepsy(OFE)in some districts of northern Uganda.Methods:In 2012,a population-based community survey of NS/epilepsy was carried out by the Ugandan Ministry of Health in Kitgum and Pader districts.In August 2017,we conducted a new survey in selected villages of these districts and compared our findings with the 2012 data.In addition,two villages in Moyo distria(where CDTI was ongoing since 1993)served as comparative onchocerciasis-endemic sites in which larviciding had never been implemented.The comparison between 2012 and 2017 prevalence and cumulative incidence were done using the Fisher's and Pearson's Chi-square tests at 95%level of significance.Results:A total of 2138 individuals in 390 households were interviewed.In the seleaed villages of Kitgum and Pader,there was no significant decrease in prevalence of NS and OFE between 2012 and 2017.However,the cumulative incidence of all forms of epilepsy decreased from 1165 to 130 per 100000 persons per year(P=0.002);that of NS decreased from 490 to 43 per 100000 persons per year(P=0.037);and for OFE from 675 to 87 per 100000 persons per year(P=0.024).The median age of affeaed persons(NS and OFE)shifted from 13.5(IQR:11.0-15.0)years in 2012 to 18.0(IQR:15.0-20.3)years in 2017;P<0.001.The age-standardized prevalence of OFE in Moyo in 2017 was 4.6%,similar to 4.5%in Kitgum and Pader.Conclusions:Our findings support the growing evidence of a relationship between infection by Onchocerca volvulus and some types of childhood epilepsy,and suggest that a combination of bi-annual mass distribution of ivermectin and ground larviciding of rivers is an effective strategy to prevent NS and OFE in onchocerciasis-hyperendemic areas. | Nolbert Gumisiriza Frank Mubiru Joseph Nelson Siewe Fodjo Martin Mbonye Kayitale An Hotterbeekx Richard Idro Issa Makumbi Tom Lakwo Bernard Opar Joice Kaducu Joseph Francis Wamala Robert Colebunders | 2020 | Infectious Diseases of Poverty2020，9，2： | 1 |
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