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	题名	作者	年代	出处	被引量
1	Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in normoglycemic and streptozotocin—induced hyperglycemic rats显示文摘Objective:To evaluate the methanol leaf extract of Diaphonathe bidem(D.bidenx)(AFZEL EX SW) SCHLTR for antihyperglycemic activity in order to confirm it antidiabetic potential.Methods: D.bidenx was extracted by cold maceration for 48 h and concentrated in vacuo to yield D.bidenx extract(DBE).Hyperglycemia was induced by intraperitoneal administration of slreplozotocin (75 mg/kg).Oral glucose tolerance test was done with 2 g/kg glucose load in normal rats.DBE (150.300 and 600 mg/kg) was administered orally,while tolbutamide(100 mg/kg.p.o.) was used as the standard reference drug.Blood glucose levels determined using ACCUCHEK glucose autoanalyzer. The acute toxicity and phytochemical studies were also carried out.Results:DBF. (600 mg/kg) and tolbutamide(100 mg/kg) significantly(P<0.05,0.005) reduced blood glucose levels of rats between 120 and 480 nun post administration in normal rats.In the streptozotoeininduced hyperglycemic rats,DBE(150.300.600 mg/kg) caused significant(P<0.001)dose- and time- dependent reduction in the blood glucose levels by 1.7%.22.8%and 43.4%,respectively at 480 min compared to the negative control group.DBE(600 mg/kg) reduced the blood glucose level of rats by 1.2%in the oral glucose tolerance test when compared with the normal saline treated group.The acute toxicity test showed that DBE was safe at the doses used and the phytochemical screening revealed the presence of saponins,steroids,tannins and terpernoids.Conclusions:D. bidens extract possess antihyperglycemic activity which may be mediated through pancreatic and extra-pancreatic pathways,thereby justifying it folkloric use.	Anaga Aruh Ottah Onuoha Augustine Igboeli Okechukwu Obiora Ezeja Maxwell	2012	Asian Pacific Journal of Tropical Medicine2012，5，3：	3
2	Inhibitory mechanism of mild steel corrosion in 2<ce:hsp sp='0.25'/>M sulphuric acid solution by methylene blue dye显示文摘	E.E. Oguzie G.N. Onuoha A.I. Onuchukwu	2004	Materials Chemistry and Physics2004，，2：	1
3	Regulatory peptides in the heart andmajor vessels ofman andmammals 显示文摘	Onuoha GN Nicholls DP Alpar EK	1999	Neuropeptides1999，33，2：	1
4	Neuropeptide secretion in exercise显示文摘	Onuoha G N Nicholls D P Patterson A	1998	Neuropeptides1998，32，：	1
5	The Association Between Barrett’s Esophagus and Helicobacter pylori Infection: A Meta‐Analysis显示文摘	Lori A.Fischbach HelenaNordenstedt Jennifer R.Kramer SubiGandhi SamDick‐Onuoha AnthonyLewis Hashem B.El‐Serag	2012	Helicobacter2012，，3：	1
6	Circulating sensory peptide levels within 24 h of human bone fracture 显示文摘	Onuoha GN	2001	Peptides2001，，22：	1
7	Management of chronic pain in whiplash injury显示文摘	Alpar E K Onuoha G Killampalli V V	2003	J Bone Joint Surg Br2003，84，6：	1
8	Vasoactive intestinal peptide and nitric oxide in the acute phase following burn sand trauma显示文摘	Onuoha G Alpar K Jones I	2001	Burns2001，27，1：	1
9	Evaluation of the inhibitory effect of methylene blue dye on the corrosion of aluminium in hydrochloric acid 显示文摘	OGUZIE E E OKOLUE B N EBENSO E E ONUOHA G N ONUCHUKWU A I	2004	Materials Chemistry and Physics2004，87，：	1
10	Neuropeptide secretion in exercise显示文摘	Onuoha G N Nicholls D P Patterson A	1998	Neuropeptides1998，32，：	1
11	Electrochemical generation and reactions of ferrylmyoglobin in water and microemulsions显示文摘	Onuoha A C Zu X Rusling J F	1997	J Am Chem Soc1997，119，：	1
12	Neuropeptide secretion in exercise显示文摘	Onuoha G N Nicholls D P Patterson A	1998	Neuropeptides1998，32，4：	1
13	Structural studies on the co-chaperone Hop and its complexes with Hsp90显示文摘	Onuoha S C Coulstock E T Grossmann J G	2008	J Mol Biol2008，379，4：	1
14	Information gathering strategies in online social networks : a survey of librarians in selected geo- political zones in Nigeria 显示文摘	ONUOHA U D UKACHI N B	2013	New Media and Mass Communi- cation2013，19，：	1
15	Response to a bo- lus of conivaptan in patients with acute hyponatremia after brain injury 显示文摘	Human T Onuoha A Diringer M	2012	J Crit Care2012，27，6：	1
16	New statistical grain-size method for evaluating the hydraulic conductivity of sandy aquifers显示文摘	Uma K O Egboka Onuoha B C E	1989	Journal of Hydrology1989，108，：	1
17	Inhibitory mechanism of mild steel corrosion in 2 M sulphuric acid solution by methylene blue dye 显示文摘	Oguzie E E Onuoha G N Onuchukwu A I	2005	Materials Chemistry Physics2005，89，：	1
18	Regulatory peptide in the heart and major vessels of man And mammals显示文摘	Onuoha GN Nichlls DP Alpar EK	1999	Neuropeptides1999，33，2：	1
19	Eleration of Plasma CGBP and SP Levels in orthopetic patients with fracture neck of femur显示文摘	Onuoha GN ALParEK	2000	Neuropeptides2000，34，2：	1
20	Calcitonin gene-related peptide and other neuropeptides in the plasma of patients with soft tissue injury 显示文摘	Onuoha G N Alpar E K	1999	Life Sci1999，65，13：	1

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