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| 1 | Mixed-histologic-type submucosal invasive gastric cancer as a risk factor for lymph node metastasis: feasibility of endoscopic submucosal dissection显示文摘 | N. Hanaoka S. Tanabe T. Mikami I. Okayasu K. Saigenji | 2009 | Endoscopy2009，，05： | 4 |
| 2 | Threshold changes in vegetation along a grazing gradient in Mongolian rangelands显示文摘 | Sasaki T Okayasu T Jamsran U Takeuchi K | | 0，，： | 1 |
| 3 | Pharmaeotherapeu- tic determinants for QTe interval prolongation in Japanese patients with mood disorder 显示文摘 | Okayasu H Ozeki Y Fujii K | 2012 | Pharmacopsychiatry2012，45，7： | 1 |
| 4 | Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk+ ganciclovir gene therapy for prostate cancer显示文摘Objective:Cytopathic effects and local immune response were analyzed histologically in prostatic cancer(PCa)with in situ herpes simplex virus-thymidine kinase(HSV-tk)/ganciclovir(GCV)gene therapy(GT).Methods:Four high-risk PCa patients who received HSV-tk/GCV GT were investigated.After two cycles of intraprostatic injection of HSV-tk and administration of GCV,radical prostatectomy was performed.Formalin-fixed,paraffin-embedded sections were evaluated using immunohistochemistry.PCa with hormone therapy(HT,n=3)or without neoadjuvant therapy(NT,n=4)that were equivalent in terms of risk were also examined as reference.Immunoreactively-positive cells were counted in at least three areas in cancer tissue.Labeling indices(LI)were calculated as percentage values.Results:ssDNA LI in GT increased,indicating apoptosis,as well as tumor-infiltrating lymphocytes and CD68-positive macrophages,compared with their biopsies.GT cases showed significantly higher numbers of single-stranded DNA(ssDNA)LI,CD4/CD8-positive T cells and CD68-positive macrophages including M1/M2 macrophages than HT or NT cases.However,there was no significant difference in CD20-positive B cells among the types of case.There were strong correlations between CD8+T cells and CD68+macrophages(ρ=0.656,p<0.0001)as well as CD4+T cells and CD20+B cells(ρ=0.644,p<0.0001)in PCa with GT.Conclusions:Enhanced cytopathic effect and local immune response might be indicated in PCa patients with HSV-tk/GCV gene therapy. | Nobuyuki Yanagisawa Takefumi Satoh Ken-ichi Tabata Hideyasu Tsumura Yasutomo Nasu Masami Watanabe Timothy C.Thompson Isao Okayasu Yoshiki Murakumo Shiro Baba Masatsugu Iwamura | 2021 | Asian Journal of Urology2021，8，3： | 1 |
| 5 | Cyclooxygenase-2 and inducible nitric oxide synthase expression in human asstrocytic gliomas: correlation with angiogenesis and prognosis and prognostic significance 显示文摘 | Hara A Okayasu I | 2004 | Acta Neuropathol2004，108，1： | 1 |
| 6 | Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcino genesis:stepwise over-expression of cyclin E and p53,reduction of p21 (WAF1/CIP1) and dysregulation of cyclin D1 and p27(KIP1)显示文摘 | Ohbu M Kobayashi N Okayasu I | 2001 | Histopathology2001，39，6： | 1 |
| 7 | Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas : correlation with angiogenesis and prognostic significance 显示文摘 | Hard A Okayasu 1 | 2004 | Acta Neuropathol2004，108，1： | 1 |
| 8 | Microstuccture evolution and texture development during high-temperature uniaxial compression of magnesium alloy AZ31显示文摘 | HELES L OKAYASU K FUKUTOMI H | 2006 | Mater Sci Eng A2006，430，12： | 1 |
| 9 | Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium显示文摘 | Saegusa M Okayasu I | 2000 | Jpn J Cancer Res2000，91，： | 1 |
| 10 | Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas:correlation with angiogenesis and prognostic significance显示文摘 | Hara A Okayasu I | 2004 | Acta Neuropathol (Berl)2004，108，1： | 1 |
| 11 | Screw-versus cement-re- tained implant restorations: current concepts 显示文摘 | Lee A Okayasu K Wang H L | 2010 | Implant Dentistry2010，19，1： | 1 |
| 12 | Enhanced cellular proliferation activity and cell death in chronic thyroiditis and thyroid papillary carcinoma显示文摘 | Okayasu I Saegusa M Fujiwara M | 1995 | Cancer Res Clin Oncol1995，121，12： | 1 |
| 13 | CD44 expression in normal, hyperplastic, and malignant endometrium 显示文摘 | Saegusa M Hashimura M Okayasu I | 1998 | J Patho1998，184，： | 1 |
| 14 | Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium显示文摘 | Saegusa M Okayasu I | 2000 | Jpn J Cancer Res2000，91，5： | 1 |
| 15 | A shift in sphingolipid com- position from C24 to C16 increases susceptibility to apoptosis in He-La cells显示文摘 | Sassa T Suto S Okayasu Y | 2012 | Biechim Biophys Acta2012，1821，7： | 1 |
| 16 | Study on islanding of dispersed photovoltaic power systems connected to a utility power grid显示文摘 | Okayasu K Yamagishi | 2001 | Solar Energy Proceedings of Solar Energy2001，70，6： | 1 |
| 17 | Loss of DCC gene expression during ovarian tumorigenesis:relation to tumor differetiation and progression显示文摘 | Machida D Okayasu I | 2000 | British J of Cancer2000，82，： | 1 |
| 18 | Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium显示文摘 | Saegusa M Okayasu I | 2000 | Jpn J Cancer Res2000，91，： | 1 |
| 19 | Purification and partial characterization of linoleoyl-CoA desaturase from rat liver mlcrosomes显示文摘 | Okayasu T Nagao M Ishibashi T | 1981 | Arch Biochem Biophys1981，206，： | 1 |
| 20 | Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas:correlation with angiogenesis and prognostic significance显示文摘 | Hara A Okayasu I | 2004 | Acta Neuropathol2004，，108： | 1 |
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