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| 1 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008，18，10： | 17 |
| 2 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 3 | Sentinel lymph node detection in patients with endometrial cancer显示文摘 | Niikura H Okamura C Utstmomiya H | 2004 | Gynecol Oncol2004，92，2： | 1 |
| 4 | Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-l-deficient mice显示文摘 | van Genderen C Okamura R M Farinas I | 1994 | Genes & Development1994，8，： | 1 |
| 5 | Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue 显示文摘 | Niikura H Okamura C Akahira J | 2004 | Gynecol Oncol2004，94，： | 1 |
| 6 | MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity显示文摘 | Kleinridders A Schenten D Kǒnner A C Belgardt B F Mauer J Okamura T Wunderlich F T | | 0，，04： | 1 |
| 7 | Inhibition of ovulation,steroidogenesis and collagenolytic activity in rabbitts by sulpiride-induced hyperprolactinemia显示文摘 | Lin K C Kawamura N Okamura H | 1988 | Reprod Fert1988，83，2： | 1 |
| 8 | Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue显示文摘 | Niikura H Okamura C Akahira J | 2004 | Gynecol Oncol2004，94，2： | 1 |
| 9 | Monoterpenoid Glycosides of Glehnia littoralis Root and Rhizoma显示文摘 | Kitajima J Okamura C Ishikawa T | 1998 | Chem Pharm Bull1998，46，10： | 1 |
| 10 | Cloning and expression of the rat prolactin receptor,a member of the growth hormone/prolactin receptor gene family显示文摘 | Boutin J M Jolicoeur C Okamura H | 1988 | Cell1988，53，： | 1 |
| 11 | Developmental expression and location of IGF-I and IGF-II mRNA and protein in skeletal muscle显示文摘 | GERRARD D E OKAMURA C S RANALLETTA M A | 1998 | J Anim Sci1998，76，4： | 1 |
| 12 | Cyclic electron flow within PSII protects PSII from its photoinhibition in thylakoid membranes from spinach chloroplasts显示文摘 | Miyake C Okamura M | 2003 | Plant Cell and Physiology2003，44，5： | 1 |
| 13 | Developmental expression and location of IGF-Ⅰ and IGF-Ⅱ mRNA and protein in skeletal muscle显示文摘 | Gerrard D E Okamura C S Ranalletta M A | 1998 | J Anim Sci1998，76，4： | 1 |
| 14 | Transitory expression of alpha cardiac myosin heavy chain in a subpopulation of secondary generation muscle fibres in the pig显示文摘 | Lefaucheur L Hoffman R Okamura C Gerrard D Leger J J Rubinstein N Kelly A | 1997 | Developmental Dynamics1997，210，： | 1 |
| 15 | Developmental expression and location of IGF-Ⅰ and IGF-Ⅱ mRNA and protein in skeletal muscle显示文摘 | Gerrard D E Okamura C S Ranalletta M A | 1998 | J Anim Sci1998，76，4： | 1 |
| 16 | Develop-mental expression and location of IGF-Ⅰ and IGF-Ⅱ mRNA and proteinin skeletal muscle显示文摘 | Gerrard D E Okamura C S Ranallela M A Grant A L | 1998 | J Anim Sei1998，76，4： | 1 |
| 17 | Force modeling for needle insertion into soft tissue显示文摘 | Okamura A M Simone C O'Leary M | 2004 | IEEE Trans On Bi-ome-dical Engineering2004，10，51： | 1 |
| 18 | Using a force-feedback joystick to teach dynamic systems显示文摘 | Okamura A M Richard C Cutkosky W K | 2002 | Journal of Engineering Education2002，91，3： | 1 |
| 19 | Kinematic calibration using the product of exponentials formula显示文摘 | Okamura K Park F C | 1996 | Robotica1996，14，4： | 1 |
| 20 | Kinematic calibration using the product of exponentials formula显示文摘 | OKAMURA K PARK F C | | 0，，： | 1 |
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