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| 1 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 2 | Metabolic activity of Streptococcus mutans biofilms and gene expression during exposure to xylitol and sucrose显示文摘The objective of the study was to analyse Streptococcus mutans biofilms grown under different dietary conditions by using multifaceted methodological approaches to gain deeper insight into the cariogenic impact of carbohydrates. S. mutans biofilms were generated during a period of 24 h in the following media: Schaedler broth as a control medium containing endogenous glucose, Schaedler broth with an additional 5% sucrose, and Schaedler broth supplemented with 1% xylitol. The confocal laser scanning microscopy(CLSM)-based analyses of the microbial vitality, respiratory activity(5-cyano-2,3-ditolyl tetrazolium chloride, CTC) and production of extracellular polysaccharides(EPS) were performed separately in the inner, middle and outer biofilm layers. In addition to the microbiological sample testing, the glucose/sucrose consumption of the biofilm bacteria was quantified, and the expression of glucosyltransferases and other biofilm-associated genes was investigated. Xylitol exposure did not inhibit the viability of S. mutans biofilms, as monitored by the following experimental parameters: culture growth, vitality, CTC activity and EPS production. However,xylitol exposure caused a difference in gene expression compared to the control. Gtf C was upregulated only in the presence of xylitol.Under xylitol exposure, gtf B was upregulated by a factor of 6, while under sucrose exposure, it was upregulated by a factor of three.Compared with glucose and xylitol, sucrose increased cell vitality in all biofilm layers. In all nutrient media, the intrinsic glucose was almost completely consumed by the cells of the S. mutans biofilm within 24 h. After 24 h of biofilm formation, the multiparametric measurements showed that xylitol in the presence of glucose caused predominantly genotypic differences but did not induce metabolic differences compared to the control. Thus, the availability of dietary carbohydrates in either a pure or combined form seems to affect the cariogenic potential of S. mutans biofilms. | Eva-Maria Decker Christian Klein Dimitri Schwindt Christiane von Ohle | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 3 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 4 | Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine显示文摘 | OHL L WENDLAND M | 2004 | J Exp Med2004，199，3： | 1 |
| 5 | Distal tibia fractures : man- agement and complications of 101 cases显示文摘 | Joveniaux P Ohl X Harisboure A | 2010 | Int Orthop2010，34，4： | 1 |
| 6 | Reproducible cavitation activity in water-particle suspensions显示文摘 | Borkent B M Arora M Ohl C D | | 0，，： | 1 |
| 7 | The healthy eat- ing index : design and applications 显示文摘 | T KENNEDY E Ohls J Carlson S | 1995 | Journal of the Amer- ican Dietetic Association1995，95，10： | 1 |
| 8 | Relationship between the inflammation and coagulation pathways in patients with severe sepsis:implications for therapy with activated protein C显示文摘 | Morris PE Hite RD Ohl C | 2002 | Bio Drugs2002，16，6： | 1 |
| 9 | Salmonella:a model for bacterial pathogenesis显示文摘 | Ohl ME Miller SI | 2001 | Annu Rev Med2001，52，： | 1 |
| 10 | Sphincteric events during penile vibratory ejaculation and ejectroejaculation in men with spinal cord injuries显示文摘 | Sonksen J Ohl DA Wedemeyer G | 2001 | J Urol2001，165，2： | 1 |
| 11 | Hypothesis: apoptosis may be a mechanism for the transition to heart failure with chronic pressure overland 显示文摘 | Bring OHL | 1994 | J Mol Cell Cardiol1994，26，： | 1 |
| 12 | Differential effects of chronic stresson memory processes in the tree shrew显示文摘 | Ohl F Fuchs E | 1999 | Brain Res CognBrain Res1999，7，： | 1 |
| 13 | Functional properties of a phenylalanine ammonia-lyase promoter from Arabidopsis显示文摘 | Ohl S Hedrick S A Chory J | 1990 | The Plant Cell1990，9，： | 1 |
| 14 | The healthy eating index: design and applications 显示文摘 | KENNEDY E T OHLS J CARLSON S | 1995 | J Am Diet Assoc1995，95，： | 1 |
| 15 | Effects of perfusion pressure on myocardial performance, metabolism and wall thinkness ,and compliance显示文摘 | Bing OHL Gasch WH | 1982 | J Thorac Cardiovasc Surg,1982，84，4： | 1 |
| 16 | Increased eardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat 显示文摘 | Li ZH Bing OHL Long XL | 1997 | Am J Physiol Heart Cric Physiol1997，272，： | 1 |
| 17 | Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance显示文摘 | Limmer A Ohl J Kurts C | 2000 | Nat Med2000，6，12： | 1 |
| 18 | Enhanced trafficking to the pancre?atic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice显示文摘 | Alam C Valkonen S Ohls S | 2010 | Diabetologia2010，53，2： | 1 |
| 19 | Particle approach to structure formation in acoustic cavitation显示文摘 | Mettin R Ohl C D Lauterborn W | 1999 | Nato ASI Series C: Mathematical and Physical Sciences1999，524，1： | 1 |
| 20 | Neuroprotective effects of erythropoiesis-stimulating agents in term and preterm neonates显示文摘 | Messier AM Ohls RK | 2014 | Curr Opin Pediatr2014，26，2： | 1 |
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