| 1 | Differential Responses to UVB Irradiation in Human Keratinocytes and Epidermoid Carcinoma Cells显示文摘Objective To examine UVB-induced responses in normal human keratinocytes (HaCaT) and epidermoid carcinoma cells (A431) at the cellular and molecular level, and investigated the protective effect of salidroside. Methods Cells irradiated by UVB at various dosage and their viability was assessed by MTT assays, cell cycle was analysed by flow cytometry. The expression of NF-κB, BCL-2, and CDK6 after 50 J/m 2 UVB irradiation were detected by RT-PCR and western blotting. Results Our results confirmed greater tolerance of A341 cells to UVB-induced damage such as cell viability and cell cycle arrest, which was accompanied by differential expression changes in NF-κB, BCL-2, and CDK6. UVB exposure resulted in HaCaT cells undergoing G 1 -S phase arrest. When treated with salidroside, HaCaT survival was significantly enhanced following exposure to UVB, suggesting great therapeutic potential for this compound. Conclusion Taken together, our study suggests that A431 respond differently to UVB than normal HaCaT cells, and supports a role for NF-κB, CDK6, and BCL-2 in UVB-induced cell G 1 -S phase arrest. Furthermore, salidroside can effectively protect HaCaT from UVB irradiation. | ZHOU Mei Juan ZHENG Li GUO Ling LIU Wei Ling LV Chao JIANG Li Hong OU Cheng Shan DING Zhen Hua | 2012 | Biomedical and Environmental Sciences2012，25，5： | 2 |
| 2 | Upgrade and separation of Co from solution with low-grade Co显示文摘Upgrade and separation of Co from solution with low grade Co were studied. In the solution, the content of Co is about 1 g·L -1 , while that of Ni, Zn, Mn, Mg, Si and Ca is 0.145, 1.108, 0.119, 6.672, 0.026 and 0.200 g·L -1 , respectively. After absorbed with absorbent G-1, the content of Co in the solution is less than 1 mg·L -1 , the average loss rate of Co is 0.07%, while the average loss rate of Mg is 67.92%. It is demonstrated that the absorbent has selectivity to absorb Co. After the absorbent was eluted with HCl at room temperature, the solution with higher content of Co was obtained. Through being evaporated and concentrated, the contant of Co in the solution can be upgraded to 26.6 g·L -1 . At the same time, most of Si, Mg is removed, the total recovery of Co can reach as high as 98.7%. The content of Pb, Ni, Cu, Zn, Mn in the discharge solution is 1.00, 0.26, 0.21, 0.09, 0.15 mg·L -1 , respectively, and the discharge solution can reach the national discharge standard. CoCl 2 solid can be obtained and can reach chemical purity. | ZHONG Shi an,ZHOU Chun shan,OU Yang xi,CHENG Ben cheng(College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，4： | 0 |
| 3 | Construction and application of LHAASO data processing platform显示文摘Purpose The LHAASO project collects trillions of cosmic ray events every year,generating about 10 PB of raw data annually,which brings big challenges for data processing platform.Method The LHAASO data processing platform is built to handle such a large amount of data,which is composed of some subsystems such as data transfer,data storage,high throughput computing and metadata management.Results and conclusions The platform was under construction since 2018 and has been working well since 2021.In this paper,the details of the design,implementation and performance of the data processing platform are presented. | Yaodong Cheng Haibo Li Yujiang Bi Jingyan Shi Shan Zeng Hongmei Zhang Ge Ou Mengyao Qi Qiuling Yao Yaosong Cheng | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
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