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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Antenna-assisted picosecond control of nanoscale phase transition in vanadium dioxide显示文摘Nanoscale devices in which the interaction with light can be configured using external control signals hold great interest for next-generation optoelectronic circuits.Materials exhibiting a structural or electronic phase transition offer a large modulation contrast with multi-level optical switching and memory functionalities.In addition,plasmonic nanoantennas can provide an efficient enhancement mechanism for both the optically induced excitation and the readout of materials strategically positioned in their local environment.Here,we demonstrate picosecond all-optical switching of the local phase transition in plasmonic antenna-vanadium dioxide(VO_(2))hybrids,exploiting strong resonant field enhancement and selective optical pumping in plasmonic hotspots.Polarization-and wavelength-dependent pump–probe spectroscopy of multifrequency crossed antenna arrays shows that nanoscale optical switching in plasmonic hotspots does not affect neighboring antennas placed within 100 nm of the excited antennas.The antenna-assisted pumping mechanism is confirmed by numerical model calculations of the resonant,antenna-mediated local heating on a picosecond time scale.The hybrid,nanoscale excitation mechanism results in 20 times reduced switching energies and 5 times faster recovery times than a VO_(2) film without antennas,enabling fully reversible switching at over two million cycles per second and at local switching energies in the picojoule range.The hybrid solution of antennas and VO_(2) provides a conceptual framework to merge the field localization and phase-transition response,enabling precise,nanoscale optical memory functionalities. | Otto L Muskens Luca Bergamini Yudong Wang Jeffrey M Gaskell Nerea Zabala CH de Groot David W Sheel Javier Aizpurua | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 3 | Addition of senna improves quality of colonoscopy preparation with magnesium citrate显示文摘AIM: To prospectively investigate the effectiveness and patient’s tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS: A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with magnesium citrate alone (n = 160) or magnesium citrate and senna granules (n = 182). The colonoscopist rated the overall efficacy of colon cleansing using an established score on a 4-point scale. Patients were questioned before undergoing colonoscopy for side effects and symptoms during bowel preparation. RESULTS: The percentage of procedures rescheduled because ofinsufficient colon cleansing was 7% in the magnesium citrate group and 4% in the magnesium citrate/senna group (P = 0.44). Adequate visualization of the colonic mucosa was rated superior under the citramag/senna regimen (P = 0.004). Both regimens were well tolerated, and did not significantly differ in the occurrence of nausea, bloating or headache.However, abdominal cramps were observed more often under the senna protocol (29.2%) compared to the magnesium citrate only protocol (9.9%, P < 0.0003). CONCLUSION: The addition of senna to the bowel preparation protocol with magnesium citrate significantly improves the cleansing outcome. | Stergios Vradelis Evangelos Kalaitzakis Yalda Sharifi Otto Buchel Satish Keshav Roger W Chapman Barbara Braden | 2009 | World Journal of Gastroenterology2009，15，14： | 3 |
| 4 | A 'region-growing' algorithm for matching of terrain images显示文摘 | OTTO G P CHAU T K W | 1989 | Image and Vision Computing1989，7，2： | 1 |
| 5 | Post- traumatic stress disorder symptoms following media exposure to tragic events: Impact of 9/11 on children at risk for anxiety disorders显示文摘 | Otto M W Henin A Hirshfeld- Becker D R | 2007 | Journal of Anxiety Disorders2007，21，7： | 1 |
| 6 | Tomorrow's skeleton staff: mesenchymal stem cells and the repair of bone and cartilage 显示文摘 | Otto W R Rao J | 2004 | Cell Prolif2004，37，18： | 1 |
| 7 | Characterization of PdJgamma-Alumina catalysts containing ceria 显示文摘 | Shyu J Z Otto K Watkins W L H | 1988 | J Catal1988，，114： | 1 |
| 8 | 'Region-growing” algorithm for matching of terrain images显示文摘 | Otto G P Chau T K W | | 0，，02： | 1 |
| 9 | Depression and influence on reproductive endocrine and menstrual cycle markers associated with perimenopause:the Harvard Study of Moods and Cycles显示文摘 | HARLOW B L WISE L A OTTO M W | 2003 | Arch Gen Psychiatry2003，60，1： | 1 |
| 10 | Sigmoid sinus Diverticulum:a new surgical approach to the correction of pulsatile tinnitus显示文摘 | Otto KJ Hudgins PA Abdelkafy W | 2007 | Otol Neurotol2007，28，： | 1 |
| 11 | Sigmoid sinus diverticulum: a new surgical approach to the correction of pulsatile tinnitus显示文摘 | OTTO K J HUDGINS P A ABDELKAFY W | 2007 | Otol Neurotol2007，28，： | 1 |
| 12 | Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons显示文摘 | ANAND U OTTO W R ANAND P | 2010 | Mol Pain2010，6，： | 1 |
| 13 | Lung epithelial stem cells 显示文摘 | OTTO W R | 2002 | J Patho12002，197，4： | 1 |
| 14 | Analysis of muhi-outrigger- braced structures 显示文摘 | Coull A Otto Lau W H | 1987 | Journal of Structural Engineering1987，10，： | 1 |
| 15 | Sesqui- and diterpenoid biomarkers preserved in Taxodium-rieh Oligocene oxbow lake clays,Weisselster basin, Germany显示文摘 | Otto A Walther H Puttmann W | 1997 | Organic Geochemistry1997，26，12： | 1 |
| 16 | Inverse relation of Ecadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas显示文摘 | Otto T Birchmeier W Schmidt U | 1994 | Cancer Res1994，54，12： | 1 |
| 17 | Evolution of neuroendoerine peptide systems: Gonadotropin--releasing hormone and somatostatin显示文摘 | Lin X W Otto Carla J Peter R E | 1998 | Comparative Biochemistry and Physiology C1998，119，： | 1 |
| 18 | Endogenous and exogenous glucocorticoids decrease plasma Ghrelin in humans 显示文摘 | Otto B Tsctop M H eldwein W | 2004 | Eur J Endocrinol2004，151，1： | 1 |
| 19 | Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly 显示文摘 | OTtO C M LIND B K KITZMAN D W | 1999 | N Engl J Med1999，341，1： | 1 |
| 20 | Gender differences in stage-adjusted bladder cancer survival显示文摘 | N.Aydin Mungan Katja K.H Aben Mark P Schoenberg Otto Visser Jan-Willem W Coebergh J.Alfred Witjes Lambertus A.L.M Kiemeney | 2000 | Urology2000，，6： | 1 |
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