|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 2 | Architects' perspectives on construction waste reduction by design显示文摘 | Osmani M Glass J Price A D F | | 0，，07： | 1 |
| 3 | Taxaneinduced peripheral neuropathy has good long-term prognosis:a 1-to 13-year evaluation显示文摘 | Osmani K Vignes S Aissi M | 2012 | J Neurol2012，259，9： | 1 |
| 4 | Architects' perspectives on construction waste reduction by design显示文摘 | Osmani M GlassJ Price A | 2008 | Waste Man?agement2008，28，： | 1 |
| 5 | Architects' Perspectives onConstruction Waste Reduction by Design显示文摘 | Osmani M Glass J Price A D F | 2008 | Waste Manage-ment2008，，7： | 1 |
| 6 | Synthesis of Lange couplers显示文摘 | R M Osmani | 1981 | IEEE Transac- lions on Microwave Theory and Techniques1981，29，2： | 1 |
| 7 | Architect and contractor attitudes to waste minimization显示文摘 | OSMANI M GLASS J PRICE A | 2006 | Waste and Resource Management2006，159，05： | 1 |
| 8 | Architects’perspectives on construction waste reduction by design显示文摘 | OSMANI M J GLASS A D F PRICE | 2008 | Waste Management2008，28，7： | 1 |
| 9 | A BIM-aided construction waste minimisation fi'amework显示文摘 | Liu Z Osmani M Demian P | 2015 | Automation in Construction2015，，59： | 1 |
| 10 | Identification of Hepatitis A virus mimotopes by phagedisplay, antigenicity and immu-nogenicity显示文摘 | OSMANY G L RAIZA M FRANK C | 2007 | Journal of Virological Methods2007，，140： | 1 |
| 11 | Etiology and susceptibility of urinary tract isolates in Kosova显示文摘 | L Raka G M Osmani L Berisha | 2004 | International Journal of Antimicrobial Agents2004，23，1： | 1 |
| 12 | Architects' perspectives on construction waste reduction by design 显示文摘 | Osmani M Glass J Price ADF | 2008 | Waste Management2008，28，7： | 1 |
| 13 | Fracture tough- ness of WC-Co cemented carbides at room temperature 显示文摘 | Bouaouadja N Hamidouche M Osmani H | 1994 | Journal of Materials Science Letters1994，13，1： | 1 |
| 14 | Insecticidal properties of plant extract of Cuminum cyminumL 显示文摘 | PUROHIT P MUSTAFA M OSMANI Z | 1983 | Science and Culture1983，49，4： | 1 |
| 15 | The sub-cellular localisation and regulatory properties of pyruvate carboxylase from Rhizopus arrhizus显示文摘 | OSMANI S A SCRUTTON M C | | 0，，01： | 1 |
| 16 | Substrate specificities of family 1 UGTs gained by domain swapping显示文摘 | Hansen E H Osmani S A Kristensen C M?ller B L Hansen J | 2009 | Phytochemistry2009，70，4： | 1 |
| 17 | The sub-cellular localisation of pyruvate carboxylase and of some other enzymes in Aspergillus nidulans显示文摘 | OSMANI S A SCRUTTON M C | | 0，，03： | 1 |
| 18 | Improvement of the mechanical properties of glass fibre reinforced plastic waste powder filled concrete 显示文摘 | Asokan P Osmani M Price ADF | 2010 | Construction and Building Materials2010，24，4： | 1 |
| 19 | The sub-cellular localisation and regulatory properties of pyruvate carboxylase from Rhizopus arrhizus 显示文摘 | OSMANI S A SCRUTTON M C | 1985 | European Journal of Biochemistry1985，147，1： | 1 |
| 20 | The sub-cellular localization and regulatory properties of pyruvate carboxylase from Rhizopus arrhizus显示文摘 | Osmani S A Scrutton M C | 1985 | Eur J Biochem1985，147，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员