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| 1 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 2 | Architects' perspectives on construction waste reduction by design显示文摘 | Osmani M Glass J Price A D F | | 0，，07： | 1 |
| 3 | Microvascular compositetissue transfer for the management of type ⅢB and ⅢC fractures ofthe distal leg and compound foot fractures 显示文摘 | Musharrafieh R Osmani O Saghied S | 1999 | J Reconstr Microsurg1999，15，7： | 1 |
| 4 | The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in di- viding cells and ciliated epithelia 显示文摘 | Gocke CD Osmani SA Miller BA | 2000 | Histochem Cell Bioll2000，114，4： | 1 |
| 5 | Taxaneinduced peripheral neuropathy has good long-term prognosis:a 1-to 13-year evaluation显示文摘 | Osmani K Vignes S Aissi M | 2012 | J Neurol2012，259，9： | 1 |
| 6 | The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans显示文摘 | Osmani SA Mirabito PM | 2004 | Fungal Genet Biol2004，41，4： | 1 |
| 7 | NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration 显示文摘 | Xiang X Osmani AH Osmani SA | 1995 | Mol Biol Cell1995，6，： | 1 |
| 8 | Architects' perspectives on construction waste reduction by design显示文摘 | Osmani M GlassJ Price A | 2008 | Waste Man?agement2008，28，： | 1 |
| 9 | Architects' Perspectives onConstruction Waste Reduction by Design显示文摘 | Osmani M Glass J Price A D F | 2008 | Waste Manage-ment2008，，7： | 1 |
| 10 | Scrib controls Cdc42 lo- calization and activity to promote cell polarization during as- trocyte migration 显示文摘 | Osmani N Vitale N Borg JP | 2006 | Curr Biol2006，16，24： | 1 |
| 11 | N-cadherin expression level modulates integrin-mediated polarity and slxongly impacts on the speed and directionality of glial cell migration 显示文摘 | Camand E Peglion F Osmani N | 2012 | J Cell Sci2012，125，： | 1 |
| 12 | Effect of certain essential oils on mortality and metamorphosis of aedcs aegypti 显示文摘 | Osmani Z Signamony S | 1980 | Pesticides1980，14，9： | 1 |
| 13 | Outcome of febrile neu-tropenic patients on granulocyte colony stimulating factor in a ter-tiarycare hospital显示文摘 | Osmani AH Ansari TZ Masood N | 2012 | Asian Pac J Cancer Prev2012，13，6： | 1 |
| 14 | Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes,decidua,cervix and myometrium before and during labour at term显示文摘 | OsmanI Young A Ledingham MA | 2003 | Molecular Human Reproduction2003，9，1： | 1 |
| 15 | An integrated 19-GHz low-phase-noise frequency synthesiz- er in SiGe BiCMOS technology 显示文摘 | OSMANY S A HERZEL F SCHEYTT J C | 2007 | Compoun Semicon- ductor Integrated Circuit Symposium2007，44，10： | 1 |
| 16 | FM radio for indoor localization with spontaneous recalibration显示文摘 | MATIC A POPLETEEV A OSMANI V | 2010 | Pervasive and Mobile Computing2010，6，6： | 1 |
| 17 | Role of low- level laser therapy in neurorehabilitation 显示文摘 | Hashmi JT Huang YY Osmani BZ | 2010 | PMR2010，2，12： | 1 |
| 18 | Synthesis of Lange couplers显示文摘 | R M Osmani | 1981 | IEEE Transac- lions on Microwave Theory and Techniques1981，29，2： | 1 |
| 19 | Indoor positioning using FM radio显示文摘 | PAPLIATSEYEU A OSMANI V MAYORA O | 2010 | International Journal of Handheld Computing Research(IJHCR)2010，1，3： | 1 |
| 20 | Role of low-level laser therapy in neurorehabilitation显示文摘 | Hashmi JT Huang YY Osmani BZ | 2010 | PM R2010，2，122： | 1 |
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