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| 1 | 慢性淋巴细胞白血病诊治指南显示文摘流行病学
慢性淋巴细胞白血病(CLL)在西方国家很常见,占65岁以上白血病患者的65%.中位发病年龄65~70岁.30岁以下极为罕见,但20%~30%病例于55岁前发病,年发病率约3/10万.欧洲、澳大利亚、北美白人以及黑人的发病率是印度、中国及日本的20~30倍.男女之比约2:1.无确凿证据显示,接触化学物质和射线、饮食、吸烟、病毒感染和自身免疫性疾病为本病的高危因素,但患者一级和二级亲属淋巴系统恶性肿瘤发病率增高.许多家族尚存在患者后代发病年龄更早、病情更重的现象.经治和未治患者第二肿瘤发病率增高. | Oscier D Fegan C Hillman P Illide T Johnson S Maguir P Matutes M Milligan D 孙蕾 高举 | 2005 | 国外医学(输血及血液学分册)2005，28，1： | 6 |
| 2 | Multivariate analysis of prognostic factors in CLL:clinical stage,IGVH gene mutational status,and loss or mutation of p53gene are independent prognostic factors显示文摘 | OSCIER D G GARDINER A C MOULD S J | 2002 | Blood2002，100，： | 1 |
| 3 | Guidelines on the diagnosis,investigation and management chronic lymphocytic leukemia显示文摘 | OSCIER D DEARDEN C EREN E | 2012 | Br J Haematol2012，159，： | 1 |
| 4 | Guidelines on the diagnosis and management of chronic lymphocytic leukaemia 显示文摘 | Oscier D Fegan C Hillmen P | 2004 | Br J Haematol2004，125，3： | 1 |
| 5 | Chromosome abnormalities in hairy cell leukaemia varlant显示文摘 | Brito-Babapulle V Matutes E Oscier D | 1994 | Genes Chromosomes Cancer1994，10，： | 1 |
| 6 | prolymphocytic leukemia显示文摘 | OSCIER D G | 1981 | Br J Heamatol1981，48，： | 1 |
| 7 | Pri-mary myelodysplastic syndrome with complex chro-mosomal rearrangements in a patient with Klinefelters syndrome显示文摘 | ABIDI S M GRIFFITHS M OSCIER D G | 1986 | J Med Genet1986，23，： | 1 |
| 8 | Pharmacokinetic study of single doses of oral fludarabine phosphate in patients with low-grade non- Hodgkin's lymphoma and B-cell chronic lymphocytic leukemia显示文摘 | Foran JM Oscier D Orchard J | 1999 | J Clin Oncol1999，17，5： | 1 |
| 9 | British Society of Hematology:guidelines on the diagnosis and management of chronic lymphocytic leukemia显示文摘 | Oscier D Fegan C Hillmen P | | 0，，03： | 1 |
| 10 | The bioavailability of oral fludarahine phosphate is unaffected by food 显示文摘 | Oscier D Orchard J Culligan D | 2001 | Hematol J2001，2，5： | 1 |
| 11 | Alemtuzumab in combination with high-dose methylprednisolone is a logical,feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p53 defects显示文摘 | PETTITT A R MATUTES E OSCIER D | 2006 | Leukemia2006，20，： | 1 |
| 12 | Splentic marginal zone lymphoma proposals for arevision of diagnostic,staging and therapeutic critcria显示文摘 | Matutes E Oscier D Montalban C | 2008 | Leukemia2008，22，： | 1 |
| 13 | Splenic marginal zone lym-phoma proposals for a revision of diagnostic, staging and therapeutic criteria显示文摘 | Matutes E Oscier D Montalban C | 2008 | Leukemia2008，22，3： | 1 |
| 14 | Myelodysplasticsyndromes: a scoring system with prognostic significance 显示文摘 | Mufti G J Stevens J R Oscier D G | 1985 | Br J Haematol1985，59，3： | 1 |
| 15 | Overexpression of the MDM2 gene is found in some cases of hemato logical malignancies 显示文摘 | Quesnel B Preadhomme C Oscier D | 1994 | Br T Haematol1994，88，2： | 1 |
| 16 | Atypical chronic myeloid leukemias 显示文摘 | Oscier D | 1997 | Pathol Biol1997，45，： | 1 |
| 17 | Guidelines on the diagnosis and management of chronic l ymphocylic leukemia 显示文摘 | Oscier D Fegan C Hillmen P | 2004 | Fir J Haematol2004，125，3： | 1 |
| 18 | Red cell aplasia in myelodysplastic syndrome 显示文摘 | William son P J Oscier D G Bell A J | 1991 | J Clin Pathol1991，44，5： | 1 |
| 19 | Guidelines on the diagnosis and management of chronic lymphocytic leukaemia显示文摘 | Oscier D Fegan C Hillmen P | 2004 | Br J Haematol2004，125，3： | 1 |
| 20 | Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B cell lymphomas: a multicenter study of the splenic B-cell lymphoma group显示文摘 | Salido M Bar6 C Oscier D | 2010 | Blood2010，116，9： | 1 |
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