|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 2 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 4 | A Novel Blind Multiple Watermarking Technique for Images显示文摘 | Peter H w Wong Oscar C Au Y M Yeung | 2003 | IEEE Transactions on Circuits and Systems for Video Teehnology2003，13，8： | 1 |
| 5 | Highly efficient predictive zonal algorithms for fast block-matching motion estimation 显示文摘 | Au Oscar C Liou Ming L | 2002 | IEEE Trans CSVT2002，12，10： | 1 |
| 6 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry显示文摘 | OSCAR J C RUSSELL M W KENNETH G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，154： | 1 |
| 7 | Aquatic manoeuvefing with counter-propaga- ting waves : a novel locomotive strategy 显示文摘 | Oscar M C | 2010 | Journal of the Royal Society2010，60，8： | 1 |
| 8 | Multiple objective genetic algorithms for path-planning optimization in autono- mous mobile robots 显示文摘 | OSCAR C LEONARDO T PATRICIA M | 2007 | Soft Computing2007，11，： | 1 |
| 9 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry 显示文摘 | Oscar J C Russell M W Kenneth G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，154： | 1 |
| 10 | Development of anautonomous navigation system using a two -dimensional laser scannerin an orchard application显示文摘 | Oscar C J Akira M Kazunobu I | 2007 | Biosystem Engineering2007，96，2： | 1 |
| 11 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry显示文摘 | Oscar J C Russell M W Kenneth G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，154，： | 1 |
| 12 | An improved method for edge detection based on interval type-2 fuzzy logic 显示文摘 | Patricia M Olivia M Oscar C | 2010 | Expert Systems with Applications2010，37，12： | 1 |
| 13 | A novel blind mul-tiple watermarking technique for images显示文摘 | Oscar C Au Yeung Y M | 2003 | IEEE Trans on Cir-cuits and Systems for Video Technology2003，13，8： | 1 |
| 14 | Development of an autonomous navigation system using a two-dimensional laser scanner in an orchard application 显示文摘 | Oscar C J Akira M Kazunobu I | 2007 | Biosystem Engineering2007，96，2： | 1 |
| 15 | Highly efficient predictive zonal algorithms for fast block-matching motion estimationM 显示文摘 | Tourapis Alexis M Au Oscar C Liou Ming L | 2002 | IEEE Transactions on Circuits System Video Technology2002，12，10： | 1 |
| 16 | A novel blind watermarking technique for images显示文摘 | Wong Peter H W Au Oscar C Yeung Y M | 2003 | IEEE Transactions on Circuits and Systems for Video Technology2003，13，8： | 1 |
| 17 | A fast detection algorithm suitable for mitigation of numerous power quality disturbances 显示文摘 | OSCAR C M PRASAD N E | 2005 | IEEE Transactions on Industry Applications2005，41，6： | 1 |
| 18 | Food microbiology Metabolism ofprebiotic products containing β (2-1) fructan mixtures by two Lactobacillus strains显示文摘 | OSCAR B LAYLA F JOSE M C | | Anaerobe0，14，： | 1 |
| 19 | Intelligent adaptive model-based control of robotic dynamic systems with a hybrid fuzzy-neural approach 显示文摘 | Oscar C Patricia M | 2003 | Applied Soft Computing Journal2003，3，4： | 1 |
| 20 | Controlled atmosphereas coadjuvant to chilled storage for prevention of melanosis inshrimps (Parapenaeus longirostris) 显示文摘 | OSCAR M A PILAR M MARIA D C G | 2005 | European Food Researchand Technology2005，220，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员