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| 1 | Imatinib-induced fatal acute liver failure显示文摘Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated or chronic phase, and also for advanced gastrointestinal stromal tumors. Severe hepatic toxicity and three deaths from hepatic failure have been reported. We report the case of a 51-year-old woman who was admitted to our institution with severe acute hepatitis. She was diagnosed with CML and began treatment with imatinib mesylate at a dose of 400 mg/d. Five months after beginning treatment, she developed severe hepatitis associated with coagulopathy, and was admitted to our institution. She had been consuming acetaminophen 500-1000 mg/d after the onset of symptoms. She had a progressive increase in bilirubin level and a marked decrease of clotting factor Ⅴ. Five days after admission, grade Ⅱ encephalopathy developed and she was referred for liver transplantation. Her clinical condition progressively deteriorated, and 48 h after being referred for transplantation she suffered a cardiac arrest and died. This report adds concern about the possibility of imatinib-mesylate-induced hepatotoxicity and liver failure, particularly in the case of concomitant use with acetaminophen. Liver function tests should be carefully monitored during treatment and, with the appearance of any elevation of liver function tests, treatment should be discontinued. | Ezequiel Ridruejo Roberto Cacchione Alejandra G Villamil Sebastián Marciano Adrián C Gadano Oscar G Mandó | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 2 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 5 | Delayed wound healing in aged skin rat models after thermal injury is asso- ciated with an increased MMP-9, K6 and CD44 expression 显示文摘 | Oriana S Guendalina L Oscar C | 2013 | Department of Dermatology2013，39，4： | 1 |
| 6 | Thermal oxidative degrada-tion of AES显示文摘 | Oscar C Marino G Massimo L | 1995 | Polymer Degradation and Stability1995，47，： | 1 |
| 7 | Realized gain and prediction of yield with genetically improved Pinus radiata in New Zealand显示文摘 | Susan D C Oscar G Judy D H | 1999 | For Sci1999，45，2： | 1 |
| 8 | Antibacterial activity of marine-derived fungi显示文摘 | Carsten C Oscar C Jens C F | 1999 | Mycopathologia1999，143，： | 1 |
| 9 | A new hydrated phase of cobalt(II) oxalate: crystal structure, thermal behavior and magnetic properties of {2H2O}n显示文摘 | Urko G C Oscar C Antonio L | 2004 | Inorg Chim Acta2004，357，： | 1 |
| 10 | Concurrent and simple digital controller of an AC/DC converter with power factor correction based on an FPGA显示文摘 | de ANGEL C PABLO Z OSCAR G | 2003 | IEEE Trans Power Electr2003，18，1： | 1 |
| 11 | Evolution of a Nearshore Coastal Observatory显示文摘 | OSCAR S ROBERT J C JOSH K SCOTT G | 2003 | Sea Technology2003，，11： | 1 |
| 12 | An adapt unsupervised approach toward pixcl clustering and color image segmentation 显示文摘 | YU Z OSCAR C ZOU R | 2010 | Pattern Reeognitian2010，，43： | 1 |
| 13 | Measuring triggering interaction complexity on active database显示文摘 | Oscar D Mario P Coral C | 2001 | Information Systems2001，26，1： | 1 |
| 14 | Isolation of multipotent mesenchymal stem cells from umbilical cord blood显示文摘 | Oscar KL Tom KK Wei Ming C | 2004 | Blood2004，103，8： | 1 |
| 15 | Secondary ettringite formation in concrete subjected to different curing conditions显示文摘 | OSCAR R B MILANESI A C MAIZA P J | 2000 | Cement and Concrete Research2000，30，9： | 1 |
| 16 | A Novel Blind Multiple Watermarking Technique for Images显示文摘 | Peter H w Wong Oscar C Au Y M Yeung | 2003 | IEEE Transactions on Circuits and Systems for Video Teehnology2003，13，8： | 1 |
| 17 | Highly efficient predictive zonal algorithms for fast block-matching motion estimation 显示文摘 | Au Oscar C Liou Ming L | 2002 | IEEE Trans CSVT2002，12，10： | 1 |
| 18 | Thermal degradation kinetics of anthocyanins from blood orange, blackberry, and roselle using the arrhenius, eyring, and ball models显示文摘 | Mady C Fabrice V Oscar A | 2009 | Journal of Agriculture and Food Chemistry2009，57，： | 1 |
| 19 | Chattering detection in cylindrical grinding processes using the wavelet transform 显示文摘 | OSCAR G B EDUARDO R JUAN C J | 2006 | International Journal of Machine Tools& Manufacture2006，46，12： | 1 |
| 20 | A capacity estimation technique for JPEG-to-JPEG image watermarking 显示文摘 | Wong Peter H W Oscar C AU | 2003 | IEEE Transactions on Circuits And Systems for Video Technology2003，13，8： | 1 |
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