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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Polyorogenic evolution of the Paleoproterozoic Trans-North China Belt--New insights from the Luliangshan-Hengshan-Wutaishan and Fuping massifs显示文摘 | Michel Faure Pierre Trap Wei Line Patrick Monié Olivier Bruguier | 2007 | Episodes2007，30，2： | 63 |
| 3 | Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma. | Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber | 2010 | World Journal of Gastroenterology2010，16，7： | 43 |
| 4 | Rebalancing Growth in China:A Three-Handed Approach显示文摘The present paper is an attempt to define the contours of the right macroeconomic strategy for China. In a nutshell, we believe that the package includes a decrease in saving, with a focus on private saving, an increase in the supply of services, in particular health services, and an appreciation of the RMB. This is why we refer to this strategy as a “three-handed approach”: action on the fiscal and budgetary front, accompanied by currency revaluation. We start by asking how the Chinese economy got to where it is, what the strategy has been since the beginning of the reforms, and what the main characteristics of the economy are today. We then ask what is the desirable path for the future, and which are the main policy trade-offs implied by such a path. Finally, we put the various pieces together to describe what we believe is a consistent policy package. | Olivier Blanchard Francesco Giavazzi | 2006 | China & World Economy2006，14，4： | 42 |
| 5 | Pathophysiology and prevention of postoperative peritoneal adhesions显示文摘Peritoneal adhesions represent an important clinical challenge in gastrointestinal surgery. Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical trauma, and may be considered as the pathological part of healing following any peritoneal injury, particularly due to abdominal surgery. The balance between fi brin deposition and degradation is critical in determining normal peritoneal healing or adhesion formation. Postoperative peritoneal adhesions are a major cause of morbidity resulting in multiple complications, many of which may manifest several years after the initial surgical procedure. In addition to acute small bowel obstruction, peritoneal adhesions may cause pelvic or abdominal pain, and infertility. In this paper, the authors reviewed the epidemiology, pathogenesis and various prevention strategies of adhesion formation, using Medline and PubMed search. Several preventive agents against postoperative peri-toneal adhesions have been investigated. Their role aims in activating fi brinolysis, hampering coagulation, diminishing the inflammatory response, inhibiting col-lagen synthesis or creating a barrier between adjacentwound surfaces. Their results are encouraging but most of them are contradictory and achieved mostly in animal model. Until additional fi ndings from future clinical researches, only a meticulous surgery can be recommended to reduce unnecessary morbidity and mortality rates from these untoward effects of surgery. In the current state of knowledge, pre-clinical or clini-cal studies are still necessary to evaluate the effective-ness of the several proposed prevention strategies of postoperative peritoneal adhesions. | Willy Arung Michel Meurisse Olivier Detry | 2011 | World Journal of Gastroenterology2011，17，41： | 46 |
| 6 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 7 | 用mtDNA D-环序列探讨蒙古和中国绵羊的起源及遗传多样性显示文摘为了在分子水平上探讨绵羊的起源,对中国和蒙古共20个绵羊群体、314只绵羊mtDNAD环的部分序列进行了测定。结果表明:中国绵羊和蒙古绵羊mtDNAD环区的部分序列中A、T、G、C含量没有明显的差别;蒙古绵羊的多态位点数(26.85%)略高于中国绵羊(24.22%);中国绵羊群体的单倍型多样度在青海藏羊、甘肃藏羊、甘肃高山细毛羊、青海细毛羊、甘南藏羊、小尾寒羊和滩羊群体中较高,但在湖羊和岷县黑裘皮羊中较低;蒙古绵羊的单倍型多样度在Bayad和Baidrag群体中最高,但在GobiAltai群体中最低。从总体上看,蒙古绵羊的遗传多样性要略高于中国绵羊,例如单倍型比例的平均值为86.06%(142/165)∶78.83%(108/137),单倍型多样度(Hd)的平均值为0.976∶0.936,核苷酸多样度(Pi(π))的平均值为0.036∶0.034,平均核苷酸差异数(k)的平均值为23.50∶22.46。217个中国和蒙古绵羊的单倍型序列的系统发生分析表明,中国和蒙古绵羊均有3个母系起源,被定义为A、B和C3类主要的单倍型。其中A类单倍型在所有中国绵羊群体及绝大多数蒙古绵羊群体(9/11)中占优势,平均比例为58.73%;B类单倍型居中,为24.68%;C类单倍型最少,仅为16.59%。进一步从GenBank获得的91个绵羊D环区的序列与中国和蒙古绵羊D环区的单倍型的进行网络关系分析,发现欧洲摩弗仑羊(Europeanmouflon,O.musimon)与中国和蒙古绵羊具有较近的亲缘关系,但没有发现羱羊(Argali,O.ammon)、盘羊(O.vigneibochariensis)和东方盘羊(O.ammonnigrimontana)对中国和蒙古绵羊起源有贡献的证据。 | 罗玉柱 成述儒 Batsuuri Lkhagva D.Badamdorj Olivier Hanotte 韩建林 | 2005 | Acta Genetica Sinica2005，32，12： | 38 |
| 8 | 中国绵羊群体mtDNA D-Loop的遗传多样性分析显示文摘为了研究中国家养绵羊的起源和遗传多样性,通过对143只绵羊(9个群体)的线粒体DNA(mtDNA)D-环的部分序列进行PCR扩增,测序获得1个长度为723bp的序列(含5个75bp的重复单元),137个长度为648bp的序列(含4个75bp的重复单元)。5个长度为573bp的序列(含3个75bp的重复单元),因此认为含有4个重复单元是家养绵羊mtDNAD-环的特征,mtDNA序列长度的变异主要是由于重复区重复单元次数的不同造成。对137个含有4个重复单元的序列进行分析,发现157个变异位点,占研究位点的24.22%。A、T、G、C含量分别为35.67%、27.85%、13.84%和22.64%。137个序列共发现96个单倍型,单倍型比例为70.07%,说明中国家养绵羊具有丰富的mtDNAD-环序列多态性。96个单倍型序列的系统发育树呈现出3个明显的分支,网络分析也分为明显的三支,因此认为中国家养绵羊有3个母系起源。从Genebank获得的91个绵羊D-环序列和中国的96个绵羊D-环单倍型序列研究表明,摩佛伦(Mouflon)与单倍型B聚为一类,说明摩佛伦与中国家养绵羊具有很近的亲缘关系。没有发现羱羊(Ovisammonargali)、盘羊(O.vigneibochariensis)和东方盘羊(O.ammonnigrimontana)对中国和蒙古家养绵羊起源有贡献的证据。 | 成述儒 韩建林 Olivier Hanotte 罗玉柱 | 2005 | 甘肃农业大学学报2005，40，4： | 33 |
| 9 | Cytoreductive surgery and hyperthermic intraperitonealchemotherapy in gastric cancer显示文摘Gastric cancer associated peritoneal carcinomatosis(GCPC) has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in GCPC. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery( CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) have been investigated for GCPC. HIPEC has been used for three indications in GC- as an adjuvant therapy after a curative surgery, HIPEC has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, HIPEC along with CRS is the only therapeutic modality that has resulted in longterm survival in select groups of patients; as a palliative treatment in advanced PC with intractable ascites, HIPEC has been shown to control ascites and reduce the need for frequent paracentesis. While the results of randomised trials of adjuvant HIPEC from western centres are awaited, the role of HIPEC in the treatment of GCPC is still evolving and needs larger studies before it is accepted as a standard of care. | Ramakrishnan Ayloor Seshadri Olivier Glehen | 2016 | World Journal of Gastroenterology2016，22，3： | 34 |
| 10 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 11 | 老年人高血压与认知功能障碍的关系显示文摘目的 评价老年人高血压与认知功能障碍之间的关系。方法 对 1 560例老年人进行MMSE量表测定,根据DSM IV及MCI诊断标准分为四组: 1. 认知功能正常; 2. 轻度认知功能障碍(MCI);3.阿尔茨海默病(AD); 4.血管性痴呆 (VaD)。同时测定血压并对年龄、教育程度矫正后进行统计分析。结果 AD组与正常组的平均动脉收缩压 (SBP)存在显著差异: (146. 45±21. 12)mmHgvs( 140. 29±20.06)mmHg(P<0. 01);同样VaD组的PAS也存在显著差异: (150. 33±22. 43)mmHgvs(140. 29±20. 06 )mmHg(P<0. 01);轻度认知功能障碍 (MCI)组与认知功能正常组之间的SBP也有显著差异: ( 144. 11±21. 47)mmHgvs(140. 29±20. 06 )mmHg(P<0. 01 )。AD组与正常组进行比较,其DBP水平也有升高,(84. 39±13. 37)mmHgvs(81. 01±12. 13)mmHg(P<0. 01)。且MCI组、AD组及VaD组中的高血压患者比例也较正常组明显升高(64% vs49%,P<0. 01; 67% vs49%,P<0. 01; 78% vs49%,P<0. 01)。结论老年人高血压与认知功能障碍之间存在正相关,高血压可能是老年人痴呆的危险因素。 | 陈谊 Olivier HANON | 2005 | 中国行为医学科学2005，14，2： | 24 |
| 12 | 欧洲骨质疏松和骨关节炎临床及经济学协会(ESCEO)和中国骨关节炎领域专家联合发表声明:ESCEO膝骨关节炎治疗规则应同样适用于中国患者显示文摘2014年12月,欧洲骨质疏松和骨关节炎临床及经济学协会(ESCEO)发布了膝骨关节炎(OA)治疗规则。此篇论文提供了中国OA专家将治疗规则应用于中国临床所做的评估和认可,目的是就如何为膝关节OA患者制定治疗流程提出切实可行的建议。在治疗的第1步,建议采用对症的缓慢起效骨关节炎治疗药物(SYSADOA)作为药物维持疗法,关于SYSADOA只有处方药结晶型硫酸氨基葡萄糖(p CGS)和处方药硫酸软骨素提供了高质量的证据。同时可合并扑热息痛等非甾体抗炎药物(NSAIDs),但只能作为紧急镇痛药物。外用非甾体抗炎药(NSAIDs)也可对症治疗。口服NSAIDs在第2步持续症状的高级治疗中维持核心作用。但是,口服NSAIDs在胃肠道和心血管安全性方面存在较大差异性。关节内注射透明质酸可产生持续临床益处,接受一个治疗疗程后,效应可持续长达6个月。作为手术之前的最后一步,缓释型曲马多(一种较弱的阿片类物质)可产生持续镇痛作用,且耐受性较好。 | 张志毅 段新旺 古洁若 黄慈波 姜林娣 林进 刘湘源 李泽光 马丽 齐文成 钱先 王吉波 王美美 武丽君 伍沪生 肖卫国 郑毅 张卓莉 Olivier Bruyère Jean-Yves Reginster Cyrus Cooper | 2016 | 中国实用内科杂志2016，36，9： | 20 |
| 13 | Large balloon dilation post endoscopic sphincterotomy in removal of difficult common bile duct stones:A literature review显示文摘Endoscopic sphincterotomy(ES)is the standard therapy in common bile duct(CBD)stones extraction.Large stones(≥12 mm)or multiple stones extraction may be challenging after ES alone.Endoscopic sphincterotomy followed by large balloon dilation(ESLBD)has been described as an alternative to ES in these indications.Efficacy,safety,cost-effectiveness and technical aspects of the procedure have been here reviewed.PubMed and Google Scholar search resulted in fortyone articles dealing with CBD stone extraction with12 mm or more dilation balloons after ES.ESLBD is at least as effective as ES,and reduces the need for additional mechanical lithotripsy.Adverse events rates are not statistically different after ESLBD compared to ES for pancreatitis,bleeding and perforation.However,particular attention should be paid in patients with CBD strictures,which is identified as a risk factor of perforation.ESLBD is slightly cost-effective compared to ES.A small sphincterotomy is usually performed,and may reduce bleeding rates compared to full sphincterotomy.Dilation is performed with 12-20 mm enteral balloons.Optimal inflation time is yet to be determined.The procedure can be performed safely even in patients with peri-ampullary diverticula and surgically altered anatomy.ESLBD is effective and safe in the removal of large CBD stones,however,small sphincterotomy might be preferred and CBD strictures should be considered as a relative contraindication. | Olivier Rouquette Gilles Bommelaer Armo Abergel Laurent Poincloux | 2014 | World Journal of Gastroenterology2014，20，24： | 17 |
| 14 | Biodiversity and Sequence of the Middle Triassic Panxian Marine Reptile Fauna,Guizhou Province,China显示文摘中间的三叠纪的 Panxian 动物志是一个物理标记和在结束以后跟随早三叠纪的停滞阶段的三叠纪的海洋的生态系统的快速的恢复的代表性的记录 -- 二叠的集体扑灭。十海洋的爬行动物税一在 Guanling 形成的上面的成员从 1.82 2.10 m 厚的含化石的水平被发现了,它能在石块爬行动物的 stratigraphic 分布上通过分析被细分进三张海洋的爬行动物床。更低的爬行动物床产出 sauropterygians Placodus inexpectatus 江等, 2008 并且 Lariosaurus hongguoensis 江等, 2006, ichthyopterygians Xinminosaurus catactes 江等, 2008 并且 Phalarodon cf。Phalarodon fraasi Merriam, 1910,与 Mixosaurus panxianensis 江等联系了, 2006,代表 durophagous 的优势的一个阶段税一。在这张床上,大完全的骨骼可以在长度到达多达 2.3 m,并且岩相和 chemostratigraphic 分析在底部,以及升起的海水平附近与 oxic 水环境显示一个相对深的碳酸盐平台。中间的爬行动物床产出 sauropterygian Nothosaurus yangjuanensis 江等, 2006 并且祖龙 Qianosuchus mixtus 李等, 2006,把等与 Mixosaurus panxianensis 江联系了, 2006。在这张床上的石块被它的大头针 cering 出牙和大全面身体尺寸描绘,与最大可能在长度超过 3 m。这张床可能在底部附近与相对缺氧的状况代表最深的盆的一时间。上面的爬行动物床产出 sauropterygians Wumengosaurus delicatomandibularis 江等, 2008, Keichousaurus sp, protorosaur Dinocephalosaurus 东方人是李, 2003,并且 ichthyopterygian Mixosaurus panxianensis 江等, 2006。在这张床上,爬虫税一由吸喂描绘了出现,并且最长是不到 1 m。这张床对应于减少的水深度的一个时期。 | JIANG Dayong Ryosuke MOTANI HAO Weicheng Olivier RIEPPEL SUN Yuanlin Andrea TINTORI SUN Zuoyu Lars SCHMITZ | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 17 |
| 15 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 16 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 17 | Acute and persisting Th2-like immune response after fractionated colorectal γ-irradiation显示文摘AIM:To investigate if an immune imbalance may account for the development and progression of chronic radiation enteritis.We analyzed the Th1/Th2 immune response profile early and 6 mo after fractionated colorectal irradiation. METHODS:A rat model of fractionated colorectal γ-irradiation(4-Gy fractions,3 fractions per week)was designed to investigate the effects of cumulative dose on inflammatory mediators(cytokines and chemo- kines)and immune response(Th1/Th2 profile and im- munosuppressive mediator IL-10)during acute(early) response and 6 mo after the end of fractionated irradia- tion(chronic response).Analyses were performed 1 d after the cumulative doses of 16 Gy and 36 Gy and 1 d, 3 d,and 26 wk after the cumulative dose of 52 Gy. RESULTS:Without causing histological damage,fractionated radiation induced elevated expression of IL-1β, TNFα,MCP-1,and iNOS in distal colonic mucosa during the early post-irradiation phase.At that time,a Th2 profile was confirmed by expression of both the Th2-specific transcription factor GATA-3 and the chemokine receptor CCR4 and by suppression of the Th1 cytokine IFNγ/IP-10 throughout the irradiation protocol.After 6 mo,despite the 2-fold reduction of iNOS and MCP-1 levels,the Th2 profile persisted,as shown by a 50% reduction in the expression of the Th1 transcription factor T-bet,the chemokine receptor CCXCR3,and the IFNγ/ STAT1 pathway.At the same time-point,the immuno-suppressive IL-10/STAT3 pathway,known to regulate the Th1/Th2 balance,was expressed,in irradiated rats, at approximately half its level as compared to controls.This suppression was associated with an overexpression of SOCS3,which inhibits the feedback of the Th1 polarization and regulates IL-10 production. CONCLUSION:Colorectal irradiation induces Th2 polarization,defective IL-10/STAT3 pathway activation and SOCS3 overexpression.These changes,in turn,maintain a immunological imbalance that persists in the long term. | Olivier Grémy Marc Benderitter Christine Linard | 2008 | World Journal of Gastroenterology2008，14，46： | 15 |
| 18 | Delivery of dsRNA for RNAi in insects: an overview and future directions显示文摘抽象 RNA 干扰(RNAi ) 指外长的双 stranded RNA (dsRNA ) silencing 的过程互补内长的送信人 RNA。RNAi 广泛地在昆虫学的研究被使用了因为主要因为它的高特性,在为基于 RNAi 的害虫控制的许多昆虫和它的潜力的功能的 genomics 逐渐地被强调了。这评论集中于介绍 dsRNA 进昆虫房间或昆虫身体导致有效 RNAi 的途径。三个很普通的交货方法,也就是 microinjection,摄取,并且浸泡,在细节和他们的优点被说明,限制为可行 RNAi 研究的目的被总结。在这评论,我们简短也在昆虫学介绍二可能的 dsRNA 举起机械,另外的 dsRNA 交货方法和 RNAi 的历史。在 RNAi 研究影响象 transfection 试剂, dsRNA 区域的选择,长度,和 dsRNA 的稳定性那样的 RNAi 的特性和效率的因素为进一步的研究被讨论。 | Na yu Olivier Christiaens Jisheng Liu Jinzhi Niu Kaat Cappelle Silvia Caccia Hanneke Huvenne Guy Smagghe | 2013 | Insect Science2013，20，1： | 15 |
| 19 | Role of microparticles in endothelial dysfunction and arterial hypertension显示文摘Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. | Thomas Helbing Christoph Olivier Christoph Bode Martin Moser Philipp Diehl | 2014 | World Journal of Cardiology2014，6，11： | 14 |
| 20 | Sediment fingerprinting in fluvial systems:review of tracers,sediment sources and mixing models显示文摘Suspended sediments in fluvial systems originate from a myriad of diffuse and point sources,with the relative contribution from each source varying over time and space.The process of sediment fingerprinting focuses on developing methods that enable discrete sediment sources to be identified from a composite sample of suspended material.This review identifies existing methodological steps for sediment fingerprinting including fluvial and source sampling,and critically compares biogeochcmical and physical tracers used in fingerprinting studies.Implications of applying different mixing models to the same source data are explored using data from 41 catchments across Europe,Africa,Australia,Asia,and North and South America.The application of seven commonly used mixing models to two case studies from the US(North Fork Broad River watershed) and France(BIcone watershed) with local and global(genetic algorithm) optimization methods identified all outputs remained in the acceptable range of error defined by the original authors.We propose future sediment fingerprinting studies use models that combine the best explanatory parameters provided by the modified Collins(using correction factors) and Hughes(relying on iterations involving all data,and not only their mean values) models with optimization using genetic algorithms to best predict the relative contribution of sediment sources to fluvial systems. | Arman HADDADCHI Darren S.RYDER Olivier EVRARD Jon OLLEY | 2013 | International Journal of Sediment Research2013，28，4： | 14 |
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